Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892944723> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2892944723 endingPage "S15" @default.
- W2892944723 startingPage "S15" @default.
- W2892944723 abstract "CT-707, a mutant-selective inhibitor of an important cancer target, anaplastic lymphoma kinase (ALK), is designed to be a targeted therapeutic agent for non-small cell lung cancer (NSCLC) patients harboring ALK active and crizotinib resistant mutations. A rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC–MS/MS) method was developed and validated for the determination of CT-707 and its two metabolites (M1 and M2) in human plasma. The samples were purified by solid phase extraction (SPE) and separated on a BEH C18 column (2.1 × 50 mm, 1.7 μm). Electrospray ionization (ESI) in positive ion mode and multiple reactions monitoring (MRM) were used to monitor the ion transitions at m/z 636.4+ → 413.3+, 594.4+ → 494.4+, 622.5+ → 536.4+, respectively. The results indicated that the method had excellent sensitivity and selectivity. The linear range covered from 2 to 500 ng/mL for CT-707and from 1 to 100 ng/mL for M1 and M2. Intra-run and inter-run precisions (in terms of %RSD) were all <15% and the accuracies (in terms of %RE) were within the range of ±15%. The lower limit of quantification (LLOQ), matrix effect, extraction recovery, stability, dilution test and carryover test were also validated and satisfied with the criteria of validation. Finally, the method was successfully applied to a phase I clinical study of ALK-positive advanced NSCLC patients after an oral administration of CT-707." @default.
- W2892944723 created "2018-10-05" @default.
- W2892944723 creator A5009806897 @default.
- W2892944723 creator A5009815126 @default.
- W2892944723 creator A5012661991 @default.
- W2892944723 creator A5013776228 @default.
- W2892944723 creator A5021868404 @default.
- W2892944723 creator A5052450727 @default.
- W2892944723 creator A5057544128 @default.
- W2892944723 creator A5075240968 @default.
- W2892944723 creator A5089568736 @default.
- W2892944723 date "2018-10-01" @default.
- W2892944723 modified "2023-10-14" @default.
- W2892944723 title "Stabilometry in patients with Dravet Syndrome to quantitatively assess ataxia: A preliminary study" @default.
- W2892944723 doi "https://doi.org/10.1016/j.gaitpost.2018.07.123" @default.
- W2892944723 hasPublicationYear "2018" @default.
- W2892944723 type Work @default.
- W2892944723 sameAs 2892944723 @default.
- W2892944723 citedByCount "0" @default.
- W2892944723 crossrefType "journal-article" @default.
- W2892944723 hasAuthorship W2892944723A5009806897 @default.
- W2892944723 hasAuthorship W2892944723A5009815126 @default.
- W2892944723 hasAuthorship W2892944723A5012661991 @default.
- W2892944723 hasAuthorship W2892944723A5013776228 @default.
- W2892944723 hasAuthorship W2892944723A5021868404 @default.
- W2892944723 hasAuthorship W2892944723A5052450727 @default.
- W2892944723 hasAuthorship W2892944723A5057544128 @default.
- W2892944723 hasAuthorship W2892944723A5075240968 @default.
- W2892944723 hasAuthorship W2892944723A5089568736 @default.
- W2892944723 hasConcept C119128265 @default.
- W2892944723 hasConcept C126322002 @default.
- W2892944723 hasConcept C162356407 @default.
- W2892944723 hasConcept C185592680 @default.
- W2892944723 hasConcept C2776232967 @default.
- W2892944723 hasConcept C2776256026 @default.
- W2892944723 hasConcept C2779422266 @default.
- W2892944723 hasConcept C31827203 @default.
- W2892944723 hasConcept C40684141 @default.
- W2892944723 hasConcept C43617362 @default.
- W2892944723 hasConcept C71043704 @default.
- W2892944723 hasConcept C71924100 @default.
- W2892944723 hasConcept C81426234 @default.
- W2892944723 hasConceptScore W2892944723C119128265 @default.
- W2892944723 hasConceptScore W2892944723C126322002 @default.
- W2892944723 hasConceptScore W2892944723C162356407 @default.
- W2892944723 hasConceptScore W2892944723C185592680 @default.
- W2892944723 hasConceptScore W2892944723C2776232967 @default.
- W2892944723 hasConceptScore W2892944723C2776256026 @default.
- W2892944723 hasConceptScore W2892944723C2779422266 @default.
- W2892944723 hasConceptScore W2892944723C31827203 @default.
- W2892944723 hasConceptScore W2892944723C40684141 @default.
- W2892944723 hasConceptScore W2892944723C43617362 @default.
- W2892944723 hasConceptScore W2892944723C71043704 @default.
- W2892944723 hasConceptScore W2892944723C71924100 @default.
- W2892944723 hasConceptScore W2892944723C81426234 @default.
- W2892944723 hasLocation W28929447231 @default.
- W2892944723 hasOpenAccess W2892944723 @default.
- W2892944723 hasPrimaryLocation W28929447231 @default.
- W2892944723 hasRelatedWork W1277187992 @default.
- W2892944723 hasRelatedWork W1994055796 @default.
- W2892944723 hasRelatedWork W1997103078 @default.
- W2892944723 hasRelatedWork W2097413562 @default.
- W2892944723 hasRelatedWork W2117437953 @default.
- W2892944723 hasRelatedWork W2300908815 @default.
- W2892944723 hasRelatedWork W2388107703 @default.
- W2892944723 hasRelatedWork W3134784103 @default.
- W2892944723 hasRelatedWork W3143827393 @default.
- W2892944723 hasRelatedWork W3202079152 @default.
- W2892944723 hasVolume "66" @default.
- W2892944723 isParatext "false" @default.
- W2892944723 isRetracted "false" @default.
- W2892944723 magId "2892944723" @default.
- W2892944723 workType "article" @default.