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• W2892946876 abstract "ABSTRACT Background: The characteristic progression of Lewy pathology in Parkinson's disease likely involves intercellular exchange and the accumulation of misfolded α‐synuclein amplified by a prion‐like self‐templating mechanism. Silencing of the α‐synuclein gene could provide long‐lasting disease‐modifying benefits by reducing the requisite substrate for the spreading aggregation. Objectives: As a result of the poor penetration of viral vectors across the blood–brain barrier, gene therapy for central nervous system disorders requires direct injections into the affected brain regions, and invasiveness is further increased by the need for bilateral delivery to multiple brain regions. Here we test a noninvasive approach by combining low‐intensity magnetic resonance–guided focused ultrasound and intravenous microbubbles that can transiently increase the access of brain impermeant therapeutic macromolecules to targeted brain regions. Methods: Transgenic mice expressing human α‐synuclein were subjected to magnetic resonance–guided focused ultrasound targeted to 4 brain regions (hippocampus, substantia nigra, olfactory bulb, and dorsal motor nucleus) in tandem with intravenous microbubbles and an adeno‐associated virus serotype 9 vector bearing a short hairpin RNA sequence targeting the α‐synuclein gene. Results: One month following treatment, α‐synuclein immunoreactivity was decreased in targeted brain regions, whereas other neuronal markers such as synaptophysin or tyrosine hydroxylase were unchanged, and cell death and glial activation remained at basal levels. Conclusions: These results demonstrate that magnetic resonance–guided focused ultrasound can effectively, noninvasively, and simultaneously deliver viral vectors targeting α‐synuclein to multiple brain areas. Importantly, this approach may be useful to alter the progression of Lewy pathology along selected neuronal pathways, particularly as prodromal PD markers improve early diagnoses. © 2018 International Parkinson and Movement Disorder Society" @default.
• W2892946876 created "2018-10-05" @default.
• W2892946876 creator A5041421122 @default.
• W2892946876 creator A5056395849 @default.
• W2892946876 creator A5072115423 @default.
• W2892946876 creator A5083750423 @default.
• W2892946876 creator A5084282748 @default.
• W2892946876 date "2018-09-28" @default.
• W2892946876 modified "2023-09-24" @default.
• W2892946876 title "Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound" @default.
• W2892946876 cites W1237068170 @default.
• W2892946876 cites W1409374736 @default.
• W2892946876 cites W1496790952 @default.
• W2892946876 cites W1527671059 @default.
• W2892946876 cites W1721689174 @default.
• W2892946876 cites W1786270771 @default.
• W2892946876 cites W1851334881 @default.
• W2892946876 cites W1873651958 @default.
• W2892946876 cites W1918258073 @default.
• W2892946876 cites W1920030402 @default.
• W2892946876 cites W1961744561 @default.
• W2892946876 cites W1965095016 @default.
• W2892946876 cites W1966840925 @default.
• W2892946876 cites W1967187670 @default.
• W2892946876 cites W1970306306 @default.
• W2892946876 cites W1970839656 @default.
• W2892946876 cites W1974791004 @default.
• W2892946876 cites W1977267085 @default.
• W2892946876 cites W1983273019 @default.
• W2892946876 cites W1989989032 @default.
• W2892946876 cites W1997531277 @default.
• W2892946876 cites W2003736464 @default.
• W2892946876 cites W2010612415 @default.
• W2892946876 cites W2015741711 @default.
• W2892946876 cites W2016398561 @default.
• W2892946876 cites W2016855436 @default.
• W2892946876 cites W2028231726 @default.
• W2892946876 cites W2038198648 @default.
• W2892946876 cites W2038711075 @default.
• W2892946876 cites W2044407202 @default.
• W2892946876 cites W2044866051 @default.
• W2892946876 cites W2046014998 @default.
• W2892946876 cites W2046885195 @default.
• W2892946876 cites W2046989255 @default.
• W2892946876 cites W2049627175 @default.
• W2892946876 cites W2050647292 @default.
• W2892946876 cites W2050786534 @default.
• W2892946876 cites W2051097977 @default.
• W2892946876 cites W2053176712 @default.
• W2892946876 cites W2054714985 @default.
• W2892946876 cites W2059261643 @default.
• W2892946876 cites W2072427499 @default.
• W2892946876 cites W2073449985 @default.
• W2892946876 cites W2075793841 @default.
• W2892946876 cites W2075927534 @default.
• W2892946876 cites W2081355012 @default.
• W2892946876 cites W2081998222 @default.
• W2892946876 cites W2082319347 @default.
• W2892946876 cites W2082755707 @default.
• W2892946876 cites W2083111107 @default.
• W2892946876 cites W2086824808 @default.
• W2892946876 cites W2087484885 @default.
• W2892946876 cites W2087812097 @default.
• W2892946876 cites W2087966289 @default.
• W2892946876 cites W2092920458 @default.
• W2892946876 cites W2094155512 @default.
• W2892946876 cites W2094514360 @default.
• W2892946876 cites W2095519131 @default.
• W2892946876 cites W2095984716 @default.
• W2892946876 cites W2099437683 @default.
• W2892946876 cites W2106430881 @default.
• W2892946876 cites W2108277337 @default.
• W2892946876 cites W2109794373 @default.
• W2892946876 cites W2110420813 @default.
• W2892946876 cites W2115362657 @default.
• W2892946876 cites W2116249615 @default.
• W2892946876 cites W2117937193 @default.
• W2892946876 cites W2121611717 @default.
• W2892946876 cites W2123431154 @default.
• W2892946876 cites W2131358222 @default.
• W2892946876 cites W2131740469 @default.
• W2892946876 cites W2132310402 @default.
• W2892946876 cites W2139733982 @default.
• W2892946876 cites W2149602553 @default.
• W2892946876 cites W2153747061 @default.
• W2892946876 cites W2154737306 @default.
• W2892946876 cites W2156806006 @default.
• W2892946876 cites W2158419561 @default.
• W2892946876 cites W2166739815 @default.
• W2892946876 cites W2166980283 @default.
• W2892946876 cites W2169076271 @default.
• W2892946876 cites W2266148698 @default.
• W2892946876 cites W2271618092 @default.
• W2892946876 cites W2298901368 @default.
• W2892946876 cites W2314371091 @default.
• W2892946876 cites W2320669370 @default.
• W2892946876 cites W2415670156 @default.
• W2892946876 cites W2539957110 @default.

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