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- W2892948071 endingPage "180" @default.
- W2892948071 startingPage "141" @default.
- W2892948071 abstract "The introduction of fluorine in drug-like compounds is now a well-accepted and very efficient strategy in drug discovery, encouraged by the extensive synthetic methodologies available. Nowadays, not only fluorine but polyfluorinated groups such as trifluoromethyl (CF3), pentafluoroethyl (C2F5), and ultimately, pentafluorosulfanyl (SF5) have made their appearance in several biologically active molecules. Our aim, in this chapter, is to show to the readers how polyfluorinated groups can sometimes be beneficial to the properties of pharmaceutically active compounds by highlighting the structure–activity relationship studies that led to the selection of these moieties as key structural features. Metabolism and toxicity of several polyfluorinated scaffolds will also be described to highlight the utility or the inadequacy of some of these groups for a suitable drug design. An overview of polyfluorinated drugs in the market and those in clinical trial will also be reported." @default.
- W2892948071 created "2018-10-05" @default.
- W2892948071 creator A5003417223 @default.
- W2892948071 creator A5007553648 @default.
- W2892948071 creator A5047401565 @default.
- W2892948071 date "2019-01-01" @default.
- W2892948071 modified "2023-10-13" @default.
- W2892948071 title "Polyfluorinated scaffolds in drug discovery" @default.
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