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• W2892949656 abstract "Cytomegalovirus (CMV) and non-replicating adenoviral vectors can induce expanded, sustained effector-memory CD8+ T-cell responses, termed memory inflation. During murine CMV (MCMV) infection, CD4+ Tcells maintain inflationary virus-specific CD8+ T-cell responses via IL-2 but not IL-21. Adenovirus vector vaccination can induce phenotypically, functionally and transcriptionally similar inflationary responses, but it is not known how IL-21 influences the inflating memory response to adenoviral vaccination. Here, we show that IL-21 is an absolute requirement for induction and maintenance of vaccine-derived inflationary CD8+ T-cell responses. These data indicate that the induction pathway of inflationary Ad-LacZ T-cells is distinct from inflationary MCMV-specific T-cells and is highly dependent on IL-21. Our observations highlight a fundamental difference in the mechanism by which adenovirus vectors and MCMV drive inflationary T-cell responses." @default.
• W2892949656 created "2018-10-05" @default.
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• W2892949656 date "2018-11-01" @default.
• W2892949656 modified "2023-10-13" @default.
• W2892949656 title "Memory inflation following adenoviral vaccination depends on IL-21" @default.
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• W2892949656 doi "https://doi.org/10.1016/j.vaccine.2018.09.061" @default.
• W2892949656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6219444" @default.
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