FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892954306> ?p ?o ?g. }

• W2892954306 abstract "Chemotherapy-induced cognitive impairment (CICI) is a commonly reported neurotoxic side effect of chemotherapy, occurring in up to 75% cancer patients. CICI manifests as decrements in working memory, executive functioning, attention, and processing speed, and greatly interferes with patients' daily performance and quality of life. Currently no treatment for CICI has been approved by the US Food and Drug Administration. We show here that treatment with a brain-penetrating histone deacetylase 6 (HDAC6) inhibitor for two weeks was sufficient to fully reverse cisplatin-induced cognitive impairments in male mice, as demonstrated in the Y-maze test of spontaneous alternation, the novel object/place recognition test, and the puzzle box test. Normalization of cognitive impairment was associated with reversal of cisplatin-induced synaptosomal mitochondrial deficits and restoration of synaptic integrity. Mechanistically, cisplatin induced deacetylation of the microtubule protein α-tubulin and hyperphosphorylation of the microtubule-associated protein tau. These cisplatin-induced changes were reversed by HDAC6 inhibition. Our data suggest that inhibition of HDAC6 restores microtubule stability and reverses tau phosphorylation, leading to normalization of synaptosomal mitochondrial function and synaptic integrity and thereby to reversal of CICI. Remarkably, our results indicate that short-term daily treatment with the HDAC6 inhibitor was sufficient to achieve prolonged reversal of established behavioral, structural and functional deficits induced by cisplatin. Because the beneficial effects of HDAC6 inhibitors as add-ons to cancer treatment have been demonstrated in clinical trials, selective targeting of HDAC6 with brain-penetrating inhibitors appears a promising therapeutic approach for reversing chemotherapy-induced neurotoxicity while enhancing tumor control." @default.
• W2892954306 created "2018-10-05" @default.
• W2892954306 creator A5007674783 @default.
• W2892954306 creator A5013994463 @default.
• W2892954306 creator A5020212737 @default.
• W2892954306 creator A5065208828 @default.
• W2892954306 creator A5076833560 @default.
• W2892954306 date "2018-10-01" @default.
• W2892954306 modified "2023-10-14" @default.
• W2892954306 title "Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment" @default.
• W2892954306 cites W146599603 @default.
• W2892954306 cites W1718435705 @default.
• W2892954306 cites W1846838131 @default.
• W2892954306 cites W1902303720 @default.
• W2892954306 cites W1972850922 @default.
• W2892954306 cites W1972886222 @default.
• W2892954306 cites W1974049018 @default.
• W2892954306 cites W1990011854 @default.
• W2892954306 cites W1992842030 @default.
• W2892954306 cites W2003966687 @default.
• W2892954306 cites W2012887006 @default.
• W2892954306 cites W2015211242 @default.
• W2892954306 cites W2026231028 @default.
• W2892954306 cites W2034031817 @default.
• W2892954306 cites W2038394514 @default.
• W2892954306 cites W2048839541 @default.
• W2892954306 cites W2054208176 @default.
• W2892954306 cites W2059089560 @default.
• W2892954306 cites W2064836594 @default.
• W2892954306 cites W2064958479 @default.
• W2892954306 cites W2064959533 @default.
• W2892954306 cites W2069947062 @default.
• W2892954306 cites W2071559249 @default.
• W2892954306 cites W2073613416 @default.
• W2892954306 cites W2078207478 @default.
• W2892954306 cites W2082429191 @default.
• W2892954306 cites W2087961967 @default.
• W2892954306 cites W2098192159 @default.
• W2892954306 cites W2100095417 @default.
• W2892954306 cites W2104076855 @default.
• W2892954306 cites W2107804537 @default.
• W2892954306 cites W2113158650 @default.
• W2892954306 cites W2118177585 @default.
• W2892954306 cites W2138795173 @default.
• W2892954306 cites W2147485520 @default.
• W2892954306 cites W2148714108 @default.
• W2892954306 cites W2153599751 @default.
• W2892954306 cites W2162787110 @default.
• W2892954306 cites W2187509128 @default.
• W2892954306 cites W2188399911 @default.
• W2892954306 cites W2321697502 @default.
• W2892954306 cites W2429713509 @default.
• W2892954306 cites W2536701740 @default.
• W2892954306 cites W2556049444 @default.
• W2892954306 cites W2559084827 @default.
• W2892954306 cites W2569372699 @default.
• W2892954306 cites W2593043086 @default.
• W2892954306 cites W2594553294 @default.
• W2892954306 cites W2595098178 @default.
• W2892954306 cites W2607014149 @default.
• W2892954306 cites W2613492737 @default.
• W2892954306 cites W2741056309 @default.
• W2892954306 cites W2751317059 @default.
• W2892954306 cites W2765788989 @default.
• W2892954306 cites W2780627695 @default.
• W2892954306 doi "https://doi.org/10.1186/s40478-018-0604-3" @default.
• W2892954306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6166273" @default.
• W2892954306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30270813" @default.
• W2892954306 hasPublicationYear "2018" @default.
• W2892954306 type Work @default.
• W2892954306 sameAs 2892954306 @default.
• W2892954306 citedByCount "42" @default.
• W2892954306 countsByYear W28929543062019 @default.
• W2892954306 countsByYear W28929543062020 @default.
• W2892954306 countsByYear W28929543062021 @default.
• W2892954306 countsByYear W28929543062022 @default.
• W2892954306 countsByYear W28929543062023 @default.
• W2892954306 crossrefType "journal-article" @default.
• W2892954306 hasAuthorship W2892954306A5007674783 @default.
• W2892954306 hasAuthorship W2892954306A5013994463 @default.
• W2892954306 hasAuthorship W2892954306A5020212737 @default.
• W2892954306 hasAuthorship W2892954306A5065208828 @default.
• W2892954306 hasAuthorship W2892954306A5076833560 @default.
• W2892954306 hasBestOaLocation W28929543061 @default.
• W2892954306 hasConcept C104317684 @default.
• W2892954306 hasConcept C126322002 @default.
• W2892954306 hasConcept C15744967 @default.
• W2892954306 hasConcept C169760540 @default.
• W2892954306 hasConcept C169900460 @default.
• W2892954306 hasConcept C23681527 @default.
• W2892954306 hasConcept C2776694085 @default.
• W2892954306 hasConcept C2778239845 @default.
• W2892954306 hasConcept C2778305200 @default.
• W2892954306 hasConcept C2779491297 @default.
• W2892954306 hasConcept C29730261 @default.
• W2892954306 hasConcept C3018842126 @default.
• W2892954306 hasConcept C55493867 @default.
• W2892954306 hasConcept C64927066 @default.
• W2892954306 hasConcept C71924100 @default.
• W2892954306 hasConcept C86803240 @default.

• next