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- W2892958770 abstract "Abstract The selection of the right antibiotic and right dose necessitates clinicians understand the contribution of pharmacokinetic variability stemming from age‐related physiologic maturation and the pharmacodynamics to optimize drug exposure for clinical response. The complexity of selecting the right dose arises from the multiplicity of pediatric age groups, from premature neonates to adolescents. Body size and age (which relate to organ function) must be incorporated to optimize antibiotic dosing in this vulnerable population. In the effort to optimize and individualize drug dosing regimens, clinical pharmacometrics that incorporate population‐based pharmacokinetic modeling, Bayesian estimation, and Monte Carlo simulations are utilized as a quantitative approach to understanding and predicting the pharmacology and clinical and microbiologic efficacy of antibiotics. In addition, opportunistic study designs and alternative blood sampling strategies can serve as practical approaches to ensure successful conduct of pediatric studies. This review article examines relevant literature on optimization of antibiotic pharmacotherapy in pediatric populations published within the last decade. Specific pediatric antibiotic data, including beta‐lactam antibiotics, aminoglycosides, and vancomycin, are critically evaluated." @default.
- W2892958770 created "2018-10-05" @default.
- W2892958770 creator A5019823948 @default.
- W2892958770 creator A5066288761 @default.
- W2892958770 date "2018-09-24" @default.
- W2892958770 modified "2023-10-14" @default.
- W2892958770 title "Optimizing Antibiotic Drug Therapy in Pediatrics: Current State and Future Needs" @default.
- W2892958770 cites W1042754413 @default.
- W2892958770 cites W1912887262 @default.
- W2892958770 cites W1918235917 @default.
- W2892958770 cites W1924253734 @default.
- W2892958770 cites W1929477948 @default.
- W2892958770 cites W1951136764 @default.
- W2892958770 cites W1972576782 @default.
- W2892958770 cites W1974280087 @default.
- W2892958770 cites W1981574927 @default.
- W2892958770 cites W1981928054 @default.
- W2892958770 cites W1985541366 @default.
- W2892958770 cites W1987149305 @default.
- W2892958770 cites W1990935717 @default.
- W2892958770 cites W1991930487 @default.
- W2892958770 cites W1994796417 @default.
- W2892958770 cites W1999136349 @default.
- W2892958770 cites W2010066166 @default.
- W2892958770 cites W2021319218 @default.
- W2892958770 cites W2027265786 @default.
- W2892958770 cites W2027478669 @default.
- W2892958770 cites W2037319195 @default.
- W2892958770 cites W2037460403 @default.
- W2892958770 cites W2045388039 @default.
- W2892958770 cites W2051128505 @default.
- W2892958770 cites W2052020700 @default.
- W2892958770 cites W2053066686 @default.
- W2892958770 cites W2056894218 @default.
- W2892958770 cites W2057939341 @default.
- W2892958770 cites W2060078829 @default.
- W2892958770 cites W2064034039 @default.
- W2892958770 cites W2064206433 @default.
- W2892958770 cites W2064950424 @default.
- W2892958770 cites W2065254807 @default.
- W2892958770 cites W2066543180 @default.
- W2892958770 cites W2067942077 @default.
- W2892958770 cites W2070046316 @default.
- W2892958770 cites W2070121589 @default.
- W2892958770 cites W2073333258 @default.
- W2892958770 cites W2074441369 @default.
- W2892958770 cites W2074618161 @default.
- W2892958770 cites W2084743878 @default.
- W2892958770 cites W2087906047 @default.
- W2892958770 cites W2088996598 @default.
- W2892958770 cites W2092513656 @default.
- W2892958770 cites W2096845994 @default.
- W2892958770 cites W2099365065 @default.
- W2892958770 cites W2101779653 @default.
- W2892958770 cites W2110928488 @default.
- W2892958770 cites W2111470240 @default.
- W2892958770 cites W2114310382 @default.
- W2892958770 cites W2116819690 @default.
- W2892958770 cites W2117538827 @default.
- W2892958770 cites W2118509587 @default.
- W2892958770 cites W2118555273 @default.
- W2892958770 cites W2118600243 @default.
- W2892958770 cites W2120416054 @default.
- W2892958770 cites W2122527560 @default.
- W2892958770 cites W2122816289 @default.
- W2892958770 cites W2123305940 @default.
- W2892958770 cites W2125417606 @default.
- W2892958770 cites W2130824175 @default.
- W2892958770 cites W2131957214 @default.
- W2892958770 cites W2132491970 @default.
- W2892958770 cites W2133120422 @default.
- W2892958770 cites W2137752893 @default.
- W2892958770 cites W2139861180 @default.
- W2892958770 cites W2142365884 @default.
- W2892958770 cites W2143810337 @default.
- W2892958770 cites W2144210039 @default.
- W2892958770 cites W2145657037 @default.
- W2892958770 cites W2146292644 @default.
- W2892958770 cites W2147480827 @default.
- W2892958770 cites W2150714701 @default.
- W2892958770 cites W2151811124 @default.
- W2892958770 cites W2152930906 @default.
- W2892958770 cites W2153093832 @default.
- W2892958770 cites W2157059987 @default.
- W2892958770 cites W2158337099 @default.
- W2892958770 cites W2167485338 @default.
- W2892958770 cites W2171520630 @default.
- W2892958770 cites W2253617808 @default.
- W2892958770 cites W2281102411 @default.
- W2892958770 cites W2283019910 @default.
- W2892958770 cites W2289059788 @default.
- W2892958770 cites W2313609946 @default.
- W2892958770 cites W2333472625 @default.
- W2892958770 cites W2397920523 @default.
- W2892958770 cites W2408090071 @default.
- W2892958770 cites W2495444602 @default.
- W2892958770 cites W2514791869 @default.
- W2892958770 cites W2561478310 @default.
- W2892958770 cites W2575177537 @default.
- W2892958770 cites W2582056456 @default.