Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892964268> ?p ?o ?g. }
- W2892964268 endingPage "228" @default.
- W2892964268 startingPage "223" @default.
- W2892964268 abstract "Abstract There is emerging evidence for the participation of toll-like receptor-2 (TLR2) expressed on platelets and endothelial cells in the setting of arterial thrombosis. In isolated human platelets, TLR2/1 activation was demonstrated to induce platelet activation, secretion, aggregation, adhesion to collagen coatings and the formation of platelet–leukocyte conjugates, whereas murine platelets were less sensitive to TLR2/1 stimulation. Also, endothelial cells can be activated by stimulation with TLR2 agonists, resulting in increased expression of adhesion molecules, synthesis of inflammatory mediators and Weibel–Palade body exocytosis. Endothelial TLR2 signalling promotes atherosclerotic lesion development in mouse atherosclerosis models. Experiments with germ-free mouse models demonstrated that the presence of commensal microbiota increased endothelial von Willebrand factor synthesis in the liver through TLR2. In the carotid artery ligation model, the elevated von Willebrand factor plasma levels enhanced platelet deposition to the injury site. Furthermore, in the hyperlipidemic ApoE-deficient mouse model, TLR2 deficiency was shown to protect from ferric chloride–induced carotid artery thrombosis. This review article provides an overview on TLR2 signalling in platelets and the vascular endothelium and summarizes how TLR2 signalling contributes to arterial thrombosis." @default.
- W2892964268 created "2018-10-05" @default.
- W2892964268 creator A5017861039 @default.
- W2892964268 date "2018-09-27" @default.
- W2892964268 modified "2023-09-30" @default.
- W2892964268 title "The Involvement of Toll-like Receptor-2 in Arterial Thrombus Formation" @default.
- W2892964268 cites W1492382046 @default.
- W2892964268 cites W1503713311 @default.
- W2892964268 cites W1519835538 @default.
- W2892964268 cites W1882975800 @default.
- W2892964268 cites W1968143482 @default.
- W2892964268 cites W1970009969 @default.
- W2892964268 cites W1978369960 @default.
- W2892964268 cites W1982207491 @default.
- W2892964268 cites W1993792235 @default.
- W2892964268 cites W1994749414 @default.
- W2892964268 cites W2000055469 @default.
- W2892964268 cites W2001494483 @default.
- W2892964268 cites W2002866097 @default.
- W2892964268 cites W2003664512 @default.
- W2892964268 cites W2006082775 @default.
- W2892964268 cites W2008680963 @default.
- W2892964268 cites W2013586539 @default.
- W2892964268 cites W2018788678 @default.
- W2892964268 cites W2024637867 @default.
- W2892964268 cites W2029473544 @default.
- W2892964268 cites W2042687860 @default.
- W2892964268 cites W2045922233 @default.
- W2892964268 cites W2047889007 @default.
- W2892964268 cites W2051687702 @default.
- W2892964268 cites W2056441411 @default.
- W2892964268 cites W2059213579 @default.
- W2892964268 cites W2060935167 @default.
- W2892964268 cites W2061514779 @default.
- W2892964268 cites W2069663822 @default.
- W2892964268 cites W2072268299 @default.
- W2892964268 cites W2072629623 @default.
- W2892964268 cites W2081182178 @default.
- W2892964268 cites W2083709056 @default.
- W2892964268 cites W2088469326 @default.
- W2892964268 cites W2090579059 @default.
- W2892964268 cites W2109420700 @default.
- W2892964268 cites W2109491705 @default.
- W2892964268 cites W2114602971 @default.
- W2892964268 cites W2118461470 @default.
- W2892964268 cites W2119488140 @default.
- W2892964268 cites W2134928825 @default.
- W2892964268 cites W2149611550 @default.
- W2892964268 cites W2152163440 @default.
- W2892964268 cites W2152502508 @default.
- W2892964268 cites W2156868786 @default.
- W2892964268 cites W2157415059 @default.
- W2892964268 cites W2157752762 @default.
- W2892964268 cites W2162775093 @default.
- W2892964268 cites W2163338781 @default.
- W2892964268 cites W2165122118 @default.
- W2892964268 cites W2170261953 @default.
- W2892964268 cites W2172191543 @default.
- W2892964268 cites W2256219379 @default.
- W2892964268 cites W2508261355 @default.
- W2892964268 cites W2543957591 @default.
- W2892964268 cites W2621353746 @default.
- W2892964268 cites W2622110034 @default.
- W2892964268 cites W2742443561 @default.
- W2892964268 cites W2765802571 @default.
- W2892964268 doi "https://doi.org/10.1055/s-0038-1668164" @default.
- W2892964268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30261531" @default.
- W2892964268 hasPublicationYear "2018" @default.
- W2892964268 type Work @default.
- W2892964268 sameAs 2892964268 @default.
- W2892964268 citedByCount "5" @default.
- W2892964268 countsByYear W28929642682018 @default.
- W2892964268 countsByYear W28929642682019 @default.
- W2892964268 countsByYear W28929642682020 @default.
- W2892964268 countsByYear W28929642682021 @default.
- W2892964268 crossrefType "journal-article" @default.
- W2892964268 hasAuthorship W2892964268A5017861039 @default.
- W2892964268 hasConcept C126322002 @default.
- W2892964268 hasConcept C134018914 @default.
- W2892964268 hasConcept C136449434 @default.
- W2892964268 hasConcept C170493617 @default.
- W2892964268 hasConcept C185592680 @default.
- W2892964268 hasConcept C203014093 @default.
- W2892964268 hasConcept C2776992346 @default.
- W2892964268 hasConcept C2779394231 @default.
- W2892964268 hasConcept C2781236682 @default.
- W2892964268 hasConcept C3018697912 @default.
- W2892964268 hasConcept C71924100 @default.
- W2892964268 hasConcept C86803240 @default.
- W2892964268 hasConcept C89560881 @default.
- W2892964268 hasConcept C95444343 @default.
- W2892964268 hasConceptScore W2892964268C126322002 @default.
- W2892964268 hasConceptScore W2892964268C134018914 @default.
- W2892964268 hasConceptScore W2892964268C136449434 @default.
- W2892964268 hasConceptScore W2892964268C170493617 @default.
- W2892964268 hasConceptScore W2892964268C185592680 @default.
- W2892964268 hasConceptScore W2892964268C203014093 @default.
- W2892964268 hasConceptScore W2892964268C2776992346 @default.