FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892964827> ?p ?o ?g. }

• W2892964827 endingPage "192" @default.
• W2892964827 startingPage "185" @default.
• W2892964827 abstract "Dysfunction of the lower urinary tract commonly afflicts the middle-aged and aging male population. The etiology of lower urinary tract symptoms (LUTS) is multifactorial. Benign prostate hyperplasia, fibrosis, smooth muscle contractility, and inflammation likely contribute. Here we aim to characterize the urinary metabolomic profile associated with prostatic inflammation, which could inform future personalized diagnosis or treatment, as well as mechanistic research. Quantitative urinary metabolomics was conducted to examine molecular changes following induction of inflammation via conditional Interleukin-1β expression in prostate epithelia using a novel transgenic mouse strain. To advance method development for urinary metabolomics, we also compared different urine normalization methods and found that normalizing urine samples based on osmolality prior to LC–MS most completely separated urinary metabolite profiles of mice with and without prostate inflammation via principal component analysis. Global metabolomics was combined with advanced machine learning feature selection and classification for data analysis. Key dysregulated metabolites and pathways were identified and were relevant to prostatic inflammation, some of which overlapped with our previous study of human LUTS patients. A binary classification model was established via the support vector machine algorithm to accurately differentiate control and inflammation groups, with an area-under-the-curve value of the receiver operating characteristic of 0.81, sensitivity of 0.974 and specificity of 0.995, respectively. This study generated molecular profiles of non-bacterial prostatic inflammation, which could assist future efforts to stratify LUTS patients and develop new therapies." @default.
• W2892964827 created "2018-10-05" @default.
• W2892964827 creator A5007721996 @default.
• W2892964827 creator A5027205779 @default.
• W2892964827 creator A5028595660 @default.
• W2892964827 creator A5041353818 @default.
• W2892964827 creator A5048881491 @default.
• W2892964827 creator A5071820359 @default.
• W2892964827 creator A5073119105 @default.
• W2892964827 creator A5076097655 @default.
• W2892964827 creator A5076908186 @default.
• W2892964827 date "2018-11-01" @default.
• W2892964827 modified "2023-10-16" @default.
• W2892964827 title "Comprehensive urinary metabolomic characterization of a genetically induced mouse model of prostatic inflammation" @default.
• W2892964827 cites W1134199019 @default.
• W2892964827 cites W1522206572 @default.
• W2892964827 cites W1534612307 @default.
• W2892964827 cites W1933695508 @default.
• W2892964827 cites W1963482033 @default.
• W2892964827 cites W1966628628 @default.
• W2892964827 cites W1977899776 @default.
• W2892964827 cites W1979296085 @default.
• W2892964827 cites W1986876160 @default.
• W2892964827 cites W1986878226 @default.
• W2892964827 cites W1988222534 @default.
• W2892964827 cites W1991778398 @default.
• W2892964827 cites W2000876723 @default.
• W2892964827 cites W2005976899 @default.
• W2892964827 cites W2018377518 @default.
• W2892964827 cites W2018886797 @default.
• W2892964827 cites W2022234260 @default.
• W2892964827 cites W2035368412 @default.
• W2892964827 cites W2041705125 @default.
• W2892964827 cites W2043036732 @default.
• W2892964827 cites W2043547988 @default.
• W2892964827 cites W2058048513 @default.
• W2892964827 cites W2063380767 @default.
• W2892964827 cites W2065637056 @default.
• W2892964827 cites W2065669941 @default.
• W2892964827 cites W2081262717 @default.
• W2892964827 cites W2086432763 @default.
• W2892964827 cites W2088552272 @default.
• W2892964827 cites W2090429649 @default.
• W2892964827 cites W2092294990 @default.
• W2892964827 cites W2096282875 @default.
• W2892964827 cites W2110229619 @default.
• W2892964827 cites W2111351802 @default.
• W2892964827 cites W2116548536 @default.
• W2892964827 cites W2126591541 @default.
• W2892964827 cites W2127538013 @default.
• W2892964827 cites W2132485204 @default.
• W2892964827 cites W2133990480 @default.
• W2892964827 cites W2135607659 @default.
• W2892964827 cites W2136326878 @default.
• W2892964827 cites W2137047962 @default.
• W2892964827 cites W2138665941 @default.
• W2892964827 cites W2141650719 @default.
• W2892964827 cites W2146779833 @default.
• W2892964827 cites W2153000202 @default.
• W2892964827 cites W2158767154 @default.
• W2892964827 cites W2160466658 @default.
• W2892964827 cites W2161869976 @default.
• W2892964827 cites W2167454069 @default.
• W2892964827 cites W2167543906 @default.
• W2892964827 cites W2195361054 @default.
• W2892964827 cites W2216480156 @default.
• W2892964827 cites W2265878282 @default.
• W2892964827 cites W2299555923 @default.
• W2892964827 cites W2411747436 @default.
• W2892964827 cites W2422228333 @default.
• W2892964827 cites W2423598340 @default.
• W2892964827 cites W2488231459 @default.
• W2892964827 cites W2556441596 @default.
• W2892964827 cites W2562701216 @default.
• W2892964827 cites W2577000997 @default.
• W2892964827 cites W2702951782 @default.
• W2892964827 cites W2918062272 @default.
• W2892964827 doi "https://doi.org/10.1016/j.ijms.2018.09.017" @default.
• W2892964827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6414212" @default.
• W2892964827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30872949" @default.
• W2892964827 hasPublicationYear "2018" @default.
• W2892964827 type Work @default.
• W2892964827 sameAs 2892964827 @default.
• W2892964827 citedByCount "6" @default.
• W2892964827 countsByYear W28929648272019 @default.
• W2892964827 countsByYear W28929648272020 @default.
• W2892964827 countsByYear W28929648272021 @default.
• W2892964827 countsByYear W28929648272022 @default.
• W2892964827 countsByYear W28929648272023 @default.
• W2892964827 crossrefType "journal-article" @default.
• W2892964827 hasAuthorship W2892964827A5007721996 @default.
• W2892964827 hasAuthorship W2892964827A5027205779 @default.
• W2892964827 hasAuthorship W2892964827A5028595660 @default.
• W2892964827 hasAuthorship W2892964827A5041353818 @default.
• W2892964827 hasAuthorship W2892964827A5048881491 @default.
• W2892964827 hasAuthorship W2892964827A5071820359 @default.
• W2892964827 hasAuthorship W2892964827A5073119105 @default.
• W2892964827 hasAuthorship W2892964827A5076097655 @default.

• next