Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892965011> ?p ?o ?g. }
- W2892965011 endingPage "33" @default.
- W2892965011 startingPage "24" @default.
- W2892965011 abstract "Abstract This study is aimed to reveal morphological and functional changes in multipotent mesenchymal stromal cells (MSCs) isolated from the rat bone marrow after: (i) activation of Toll‐like receptors (TLRs) with teichoic acid (TA), (ii) impact on epidermal growth factor (EGF) receptors with activator EGF or inhibitor Herceptin, and (iii) treatment with DNA intercalator Cisplatin. According to our results, TA and EGF cause an increase in the synthesis of glycosaminoglycans, c‐Myc content, and protein in the MSC cytoplasm. It was observed that the cell population in G0 phase decreased and the cell population in G1 phase increased, when compared with control. At the same time, the cell population with a higher nuclear–cytoplasmic ratio (NCR) in S and G2 phases also increased. This indicates the manifestation of the MSC mesenchymal phenotype, exhibiting indirect metabolic signs of the regenerative potential increase. In other experiments, Herceptin was shown to suppress only the stemness signs of MSCs, while Cisplatin seriously affected cell viability in general, reducing synthetic and proliferative activities and causing cell morphology disturbances. © 2018 International Society for Advancement of Cytometry" @default.
- W2892965011 created "2018-10-05" @default.
- W2892965011 creator A5012020083 @default.
- W2892965011 creator A5012831163 @default.
- W2892965011 creator A5022045469 @default.
- W2892965011 creator A5033950944 @default.
- W2892965011 creator A5036495332 @default.
- W2892965011 creator A5040886756 @default.
- W2892965011 creator A5041434071 @default.
- W2892965011 creator A5060335913 @default.
- W2892965011 creator A5072346065 @default.
- W2892965011 creator A5074554589 @default.
- W2892965011 creator A5076210417 @default.
- W2892965011 creator A5083262584 @default.
- W2892965011 creator A5089250135 @default.
- W2892965011 creator A5091645862 @default.
- W2892965011 date "2018-09-21" @default.
- W2892965011 modified "2023-10-16" @default.
- W2892965011 title "Morpho-Functional Characteristics of Bone Marrow Multipotent Mesenchymal Stromal Cells after Activation or Inhibition of Epidermal Growth Factor and Toll-Like Receptors or Treatment with DNA Intercalator Cisplatin" @default.
- W2892965011 cites W1159008209 @default.
- W2892965011 cites W1487099323 @default.
- W2892965011 cites W1771887010 @default.
- W2892965011 cites W1949832432 @default.
- W2892965011 cites W1965777094 @default.
- W2892965011 cites W1977275853 @default.
- W2892965011 cites W1982861164 @default.
- W2892965011 cites W1983659112 @default.
- W2892965011 cites W1991563262 @default.
- W2892965011 cites W1991582633 @default.
- W2892965011 cites W1996177651 @default.
- W2892965011 cites W1997367417 @default.
- W2892965011 cites W2002145511 @default.
- W2892965011 cites W2005349078 @default.
- W2892965011 cites W2011567073 @default.
- W2892965011 cites W2022971914 @default.
- W2892965011 cites W2025371271 @default.
- W2892965011 cites W2035124125 @default.
- W2892965011 cites W2040247475 @default.
- W2892965011 cites W2043421131 @default.
- W2892965011 cites W2046718986 @default.
- W2892965011 cites W2052917322 @default.
- W2892965011 cites W2056523973 @default.
- W2892965011 cites W2059386691 @default.
- W2892965011 cites W2061548141 @default.
- W2892965011 cites W2062648563 @default.
- W2892965011 cites W2070905603 @default.
- W2892965011 cites W2071163127 @default.
- W2892965011 cites W2075320194 @default.
- W2892965011 cites W2077087448 @default.
- W2892965011 cites W2090241102 @default.
- W2892965011 cites W2095718564 @default.
- W2892965011 cites W2095767829 @default.
- W2892965011 cites W2101599697 @default.
- W2892965011 cites W2101873609 @default.
- W2892965011 cites W2125987139 @default.
- W2892965011 cites W2126608925 @default.
- W2892965011 cites W2148712176 @default.
- W2892965011 cites W2154589460 @default.
- W2892965011 cites W2170278053 @default.
- W2892965011 cites W2180091152 @default.
- W2892965011 cites W2202177797 @default.
- W2892965011 cites W2370279403 @default.
- W2892965011 cites W2401550218 @default.
- W2892965011 cites W2520913603 @default.
- W2892965011 cites W2590367459 @default.
- W2892965011 cites W2618573553 @default.
- W2892965011 cites W2726595145 @default.
- W2892965011 cites W2755610648 @default.
- W2892965011 cites W2766971919 @default.
- W2892965011 cites W2773060103 @default.
- W2892965011 cites W2791486327 @default.
- W2892965011 cites W4366111320 @default.
- W2892965011 doi "https://doi.org/10.1002/cyto.a.23593" @default.
- W2892965011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30240134" @default.
- W2892965011 hasPublicationYear "2018" @default.
- W2892965011 type Work @default.
- W2892965011 sameAs 2892965011 @default.
- W2892965011 citedByCount "4" @default.
- W2892965011 countsByYear W28929650112020 @default.
- W2892965011 countsByYear W28929650112022 @default.
- W2892965011 crossrefType "journal-article" @default.
- W2892965011 hasAuthorship W2892965011A5012020083 @default.
- W2892965011 hasAuthorship W2892965011A5012831163 @default.
- W2892965011 hasAuthorship W2892965011A5022045469 @default.
- W2892965011 hasAuthorship W2892965011A5033950944 @default.
- W2892965011 hasAuthorship W2892965011A5036495332 @default.
- W2892965011 hasAuthorship W2892965011A5040886756 @default.
- W2892965011 hasAuthorship W2892965011A5041434071 @default.
- W2892965011 hasAuthorship W2892965011A5060335913 @default.
- W2892965011 hasAuthorship W2892965011A5072346065 @default.
- W2892965011 hasAuthorship W2892965011A5074554589 @default.
- W2892965011 hasAuthorship W2892965011A5076210417 @default.
- W2892965011 hasAuthorship W2892965011A5083262584 @default.
- W2892965011 hasAuthorship W2892965011A5089250135 @default.
- W2892965011 hasAuthorship W2892965011A5091645862 @default.
- W2892965011 hasBestOaLocation W28929650111 @default.
- W2892965011 hasConcept C16930146 @default.
- W2892965011 hasConcept C170493617 @default.