Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892968387> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2892968387 abstract "Abstract In observational studies, the Mendelian randomization approach can be used to circumvent confounding, bias and reverse causation, and to assess a potential causal association between a biomarker and risk of disease. If, on the other hand, a substantial component of variance of a non-causal biomarker is explained by genotype, then genotype could potentially attenuate the observational association and the strength of the prediction. In order to reduce the component of variance explained by genotype, an approach that can be seen as the inverse of Mendelian randomization - biomarker de-Mendelization - appears plausible.Plasma YKL-40 is a good candidate for demonstrating principles of biomarker de-Mendelization because it is a non-causal biomarker with a substantial component of variance explained by genotype. This approach is an attempt to improve the observational association and the strength of a predictive biomarker; it is explicitly not aimed at detection of causal effects. We studied 21 161 individuals form the Danish general population with measurements of YKL-40 concentration and rs4950928 genotype. Four different methods for biomarker de-Mendelization are explored for alcoholic liver cirrhosis and lung cancer. De-Mendelization methods only improved predictive ability slighly. We observed an interaction between genotype and markers of developing disease with respect to YKL-40 concentration. Even when genotype explains 14% of the variance in a non-causal biomarker, we found no useful empirical improvement in risk prediction by biomarker de-Mendelization. This could reflect the predictive interaction between genotype and disease development being removed which counterbalanced any beneficial properties of the method in this situation." @default.
- W2892968387 created "2018-10-05" @default.
- W2892968387 creator A5013184354 @default.
- W2892968387 creator A5041716917 @default.
- W2892968387 creator A5063670944 @default.
- W2892968387 creator A5068346857 @default.
- W2892968387 creator A5074808099 @default.
- W2892968387 date "2018-09-28" @default.
- W2892968387 modified "2023-09-27" @default.
- W2892968387 title "Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype" @default.
- W2892968387 cites W1480869123 @default.
- W2892968387 cites W1968820001 @default.
- W2892968387 cites W1972696558 @default.
- W2892968387 cites W1982691027 @default.
- W2892968387 cites W19849081 @default.
- W2892968387 cites W1997725810 @default.
- W2892968387 cites W2022082086 @default.
- W2892968387 cites W2031852598 @default.
- W2892968387 cites W2093053972 @default.
- W2892968387 cites W2099817335 @default.
- W2892968387 cites W2100653750 @default.
- W2892968387 cites W2103783427 @default.
- W2892968387 cites W2106036991 @default.
- W2892968387 cites W2132153488 @default.
- W2892968387 cites W2134360742 @default.
- W2892968387 cites W2139875520 @default.
- W2892968387 cites W2144563531 @default.
- W2892968387 cites W2150586334 @default.
- W2892968387 cites W2168818976 @default.
- W2892968387 cites W2585524114 @default.
- W2892968387 cites W2588618729 @default.
- W2892968387 cites W2620908531 @default.
- W2892968387 cites W2791021113 @default.
- W2892968387 doi "https://doi.org/10.1101/428276" @default.
- W2892968387 hasPublicationYear "2018" @default.
- W2892968387 type Work @default.
- W2892968387 sameAs 2892968387 @default.
- W2892968387 citedByCount "3" @default.
- W2892968387 countsByYear W28929683872019 @default.
- W2892968387 countsByYear W28929683872022 @default.
- W2892968387 countsByYear W28929683872023 @default.
- W2892968387 crossrefType "posted-content" @default.
- W2892968387 hasAuthorship W2892968387A5013184354 @default.
- W2892968387 hasAuthorship W2892968387A5041716917 @default.
- W2892968387 hasAuthorship W2892968387A5063670944 @default.
- W2892968387 hasAuthorship W2892968387A5068346857 @default.
- W2892968387 hasAuthorship W2892968387A5074808099 @default.
- W2892968387 hasBestOaLocation W28929683871 @default.
- W2892968387 hasConcept C104317684 @default.
- W2892968387 hasConcept C126322002 @default.
- W2892968387 hasConcept C135763542 @default.
- W2892968387 hasConcept C143998085 @default.
- W2892968387 hasConcept C23131810 @default.
- W2892968387 hasConcept C2779901538 @default.
- W2892968387 hasConcept C2781197716 @default.
- W2892968387 hasConcept C2908647359 @default.
- W2892968387 hasConcept C2993967602 @default.
- W2892968387 hasConcept C54355233 @default.
- W2892968387 hasConcept C71924100 @default.
- W2892968387 hasConcept C77350462 @default.
- W2892968387 hasConcept C86803240 @default.
- W2892968387 hasConcept C99454951 @default.
- W2892968387 hasConceptScore W2892968387C104317684 @default.
- W2892968387 hasConceptScore W2892968387C126322002 @default.
- W2892968387 hasConceptScore W2892968387C135763542 @default.
- W2892968387 hasConceptScore W2892968387C143998085 @default.
- W2892968387 hasConceptScore W2892968387C23131810 @default.
- W2892968387 hasConceptScore W2892968387C2779901538 @default.
- W2892968387 hasConceptScore W2892968387C2781197716 @default.
- W2892968387 hasConceptScore W2892968387C2908647359 @default.
- W2892968387 hasConceptScore W2892968387C2993967602 @default.
- W2892968387 hasConceptScore W2892968387C54355233 @default.
- W2892968387 hasConceptScore W2892968387C71924100 @default.
- W2892968387 hasConceptScore W2892968387C77350462 @default.
- W2892968387 hasConceptScore W2892968387C86803240 @default.
- W2892968387 hasConceptScore W2892968387C99454951 @default.
- W2892968387 hasLocation W28929683871 @default.
- W2892968387 hasOpenAccess W2892968387 @default.
- W2892968387 hasPrimaryLocation W28929683871 @default.
- W2892968387 hasRelatedWork W1972696558 @default.
- W2892968387 hasRelatedWork W2015148400 @default.
- W2892968387 hasRelatedWork W2136482050 @default.
- W2892968387 hasRelatedWork W2198763731 @default.
- W2892968387 hasRelatedWork W2341424469 @default.
- W2892968387 hasRelatedWork W2389890604 @default.
- W2892968387 hasRelatedWork W3111647380 @default.
- W2892968387 hasRelatedWork W4206443080 @default.
- W2892968387 hasRelatedWork W4301390811 @default.
- W2892968387 hasRelatedWork W4310009619 @default.
- W2892968387 isParatext "false" @default.
- W2892968387 isRetracted "false" @default.
- W2892968387 magId "2892968387" @default.
- W2892968387 workType "article" @default.