Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892968768> ?p ?o ?g. }
- W2892968768 endingPage "1599" @default.
- W2892968768 startingPage "1593" @default.
- W2892968768 abstract "Yokukansan (YKS) is a traditional Japanese herbal medicine. It has been currently applied for treating behavioral and psychological symptoms of dementia in Japan. We investigated the effect of YKS on learning ability, hippocampal cell proliferation, and neural ultrastructural features in senescence-accelerated mouse prone 8 (SAMP8), a proposed animal model of Alzheimer’s disease. Five-month-old male SAMP8 mice were randomly assigned to control and experimental groups. The control group had drug-free water ad libitum. The experimental mice were given 0.15% aqueous solution of YKS orally for eight weeks. Learning ability was assessed in Morris water maze test. Hippocampal cell proliferation was investigated using bromodeoxyuridine immunohistochemical method. The neural ultrastructural features, including myelin sheath and synapse, were investigated electron microscopy. Administration with YKS improved the hippocampal cell proliferation in dentate gyrus, and ameliorated learning impairment in SAMP8 mice. Numerous lipofuscin inclusions were presented in hippocampal neurons of the control mice. However, little were found after treatment with YKS. Myelin sheath was thicker and postsynaptic density length was longer after treatment with YKS. Administration with YKS ameliorated learning impairment in SAMP8 mice, mediated at least partially via delaying neuronal aging process, neurogenesis, myelin sheath and synaptic plasticity in the hippocampus. These results suggest that YKS might be effective for preventing hippocampus-dependent cognitive deficits with age." @default.
- W2892968768 created "2018-10-05" @default.
- W2892968768 creator A5018623952 @default.
- W2892968768 creator A5027634537 @default.
- W2892968768 creator A5041886759 @default.
- W2892968768 creator A5045357175 @default.
- W2892968768 creator A5061288887 @default.
- W2892968768 creator A5065905182 @default.
- W2892968768 creator A5066617722 @default.
- W2892968768 creator A5087414920 @default.
- W2892968768 creator A5091623768 @default.
- W2892968768 date "2018-10-01" @default.
- W2892968768 modified "2023-09-27" @default.
- W2892968768 title "Yokukansan Ameliorates Hippocampus-Dependent Learning Impairment in Senescence-Accelerated Mouse" @default.
- W2892968768 cites W1581458838 @default.
- W2892968768 cites W1602108922 @default.
- W2892968768 cites W1974814280 @default.
- W2892968768 cites W1974855479 @default.
- W2892968768 cites W1978570053 @default.
- W2892968768 cites W1984705887 @default.
- W2892968768 cites W2001975498 @default.
- W2892968768 cites W2004335391 @default.
- W2892968768 cites W2023277820 @default.
- W2892968768 cites W2024264974 @default.
- W2892968768 cites W2025604203 @default.
- W2892968768 cites W2036347815 @default.
- W2892968768 cites W2037033984 @default.
- W2892968768 cites W2038003980 @default.
- W2892968768 cites W2038465210 @default.
- W2892968768 cites W2039677191 @default.
- W2892968768 cites W2057982379 @default.
- W2892968768 cites W2075239897 @default.
- W2892968768 cites W2082190681 @default.
- W2892968768 cites W2083127760 @default.
- W2892968768 cites W2085771812 @default.
- W2892968768 cites W2087541289 @default.
- W2892968768 cites W2092568484 @default.
- W2892968768 cites W2094045218 @default.
- W2892968768 cites W2099250398 @default.
- W2892968768 cites W2108189835 @default.
- W2892968768 cites W2114828913 @default.
- W2892968768 cites W2123367068 @default.
- W2892968768 cites W2144528735 @default.
- W2892968768 cites W2145796722 @default.
- W2892968768 cites W2147169882 @default.
- W2892968768 cites W2154626303 @default.
- W2892968768 cites W2158180455 @default.
- W2892968768 cites W2336791706 @default.
- W2892968768 cites W2468816820 @default.
- W2892968768 cites W2510243986 @default.
- W2892968768 cites W2754363836 @default.
- W2892968768 cites W4229568782 @default.
- W2892968768 doi "https://doi.org/10.1248/bpb.b18-00359" @default.
- W2892968768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30270329" @default.
- W2892968768 hasPublicationYear "2018" @default.
- W2892968768 type Work @default.
- W2892968768 sameAs 2892968768 @default.
- W2892968768 citedByCount "5" @default.
- W2892968768 countsByYear W28929687682019 @default.
- W2892968768 countsByYear W28929687682023 @default.
- W2892968768 crossrefType "journal-article" @default.
- W2892968768 hasAuthorship W2892968768A5018623952 @default.
- W2892968768 hasAuthorship W2892968768A5027634537 @default.
- W2892968768 hasAuthorship W2892968768A5041886759 @default.
- W2892968768 hasAuthorship W2892968768A5045357175 @default.
- W2892968768 hasAuthorship W2892968768A5061288887 @default.
- W2892968768 hasAuthorship W2892968768A5065905182 @default.
- W2892968768 hasAuthorship W2892968768A5066617722 @default.
- W2892968768 hasAuthorship W2892968768A5087414920 @default.
- W2892968768 hasAuthorship W2892968768A5091623768 @default.
- W2892968768 hasBestOaLocation W28929687681 @default.
- W2892968768 hasConcept C126322002 @default.
- W2892968768 hasConcept C134018914 @default.
- W2892968768 hasConcept C148762608 @default.
- W2892968768 hasConcept C169760540 @default.
- W2892968768 hasConcept C174884520 @default.
- W2892968768 hasConcept C185592680 @default.
- W2892968768 hasConcept C204232928 @default.
- W2892968768 hasConcept C2776464000 @default.
- W2892968768 hasConcept C2778260397 @default.
- W2892968768 hasConcept C2778609137 @default.
- W2892968768 hasConcept C2781161787 @default.
- W2892968768 hasConcept C44752575 @default.
- W2892968768 hasConcept C4746552 @default.
- W2892968768 hasConcept C522857546 @default.
- W2892968768 hasConcept C529278444 @default.
- W2892968768 hasConcept C71924100 @default.
- W2892968768 hasConcept C86803240 @default.
- W2892968768 hasConceptScore W2892968768C126322002 @default.
- W2892968768 hasConceptScore W2892968768C134018914 @default.
- W2892968768 hasConceptScore W2892968768C148762608 @default.
- W2892968768 hasConceptScore W2892968768C169760540 @default.
- W2892968768 hasConceptScore W2892968768C174884520 @default.
- W2892968768 hasConceptScore W2892968768C185592680 @default.
- W2892968768 hasConceptScore W2892968768C204232928 @default.
- W2892968768 hasConceptScore W2892968768C2776464000 @default.
- W2892968768 hasConceptScore W2892968768C2778260397 @default.
- W2892968768 hasConceptScore W2892968768C2778609137 @default.