FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892970757> ?p ?o ?g. }

• W2892970757 endingPage "2938" @default.
• W2892970757 startingPage "2922" @default.
• W2892970757 abstract "Dopamine (DA) depletion modifies the firing pattern of neurons in the substantia nigra pars reticulata (SNr), shifting their mostly tonic firing toward irregularity and bursting, traits of pathological firing underlying rigidity and postural instability in Parkinson’s disease (PD) patients and animal models of Parkinsonism (PS). Drug-induced Parkinsonism (DIP) represents 20–40% of clinical cases of PS, becoming a problem for differential diagnosis, and is still not well studied with physiological tools. It may co-occur with tardive dyskinesia. Here we use in vitro slice preparations including the SNr to observe drug-induced pathological firing by using drugs that most likely produce it, DA-receptor antagonists (SCH23390 plus sulpiride), to compare with firing patterns found in DA-depleted tissue. The hypothesis is that SNr firing would be similar under both conditions, a prerequisite to the proposal of a similar preparation to test other DIP-producing drugs. Firing was analyzed with three complementary metrics, showing similarities between DA depletion and acute DA-receptor blockade. Moreover, blockade of either nonselective cationic channels or Ca v 3 T-type calcium channels hyperpolarized the membrane and abolished bursting and irregular firing, silencing SNr neurons in both conditions. Therefore, currents generating firing in control conditions are in part responsible for pathological firing. Haloperidol, a DIP-producing drug, reproduced DA-receptor antagonist firing modifications. Since acute DA-receptor blockade induces SNr neuron firing similar to that found in the 6-hydroxydopamine model of PS, output basal ganglia neurons may play a role in generating DIP. Therefore, this study opens the way to test other DIP-producing drugs. NEW & NOTEWORTHY Dopamine (DA) depletion enhances substantia nigra pars reticulata (SNr) neuron bursting and irregular firing, hallmarks of Parkinsonism. Several drugs, including antipsychotics, antidepressants, and calcium channel antagonists, among others, produce drug-induced Parkinsonism. Here we show the first comparison between SNr neuron firing after DA depletion vs. firing found after acute blockade of DA receptors. It was found that firing in both conditions is similar, implying that pathological SNr neuron firing is also a physiological correlate of drug-induced Parkinsonism." @default.
• W2892970757 created "2018-10-05" @default.
• W2892970757 creator A5014822614 @default.
• W2892970757 creator A5017448695 @default.
• W2892970757 creator A5025077172 @default.
• W2892970757 creator A5036093129 @default.
• W2892970757 creator A5053912984 @default.
• W2892970757 creator A5064791807 @default.
• W2892970757 creator A5079821653 @default.
• W2892970757 date "2018-12-01" @default.
• W2892970757 modified "2023-10-16" @default.
• W2892970757 title "Acute dopamine receptor blockade in substantia nigra pars reticulata: a possible model for drug-induced Parkinsonism" @default.
• W2892970757 cites W1589762452 @default.
• W2892970757 cites W1596498541 @default.
• W2892970757 cites W1606921330 @default.
• W2892970757 cites W1757889097 @default.
• W2892970757 cites W1979415542 @default.
• W2892970757 cites W1979689261 @default.
• W2892970757 cites W1987526284 @default.
• W2892970757 cites W1987953899 @default.
• W2892970757 cites W1988321480 @default.
• W2892970757 cites W1990368279 @default.
• W2892970757 cites W1991654166 @default.
• W2892970757 cites W1991857015 @default.
• W2892970757 cites W1993349892 @default.
• W2892970757 cites W2000478038 @default.
• W2892970757 cites W2001008031 @default.
• W2892970757 cites W2001405298 @default.
• W2892970757 cites W2002572432 @default.
• W2892970757 cites W2004693301 @default.
• W2892970757 cites W2005674083 @default.
• W2892970757 cites W2007098958 @default.
• W2892970757 cites W2007281961 @default.
• W2892970757 cites W2012567998 @default.
• W2892970757 cites W2018191142 @default.
• W2892970757 cites W2021683549 @default.
• W2892970757 cites W2025141229 @default.
• W2892970757 cites W2029050611 @default.
• W2892970757 cites W2030040826 @default.
• W2892970757 cites W2031511565 @default.
• W2892970757 cites W2042520035 @default.
• W2892970757 cites W2044082693 @default.
• W2892970757 cites W2046302119 @default.
• W2892970757 cites W2046361830 @default.
• W2892970757 cites W2054154376 @default.
• W2892970757 cites W2054192805 @default.
• W2892970757 cites W2055538060 @default.
• W2892970757 cites W2057259149 @default.
• W2892970757 cites W2059370679 @default.
• W2892970757 cites W2066113689 @default.
• W2892970757 cites W2067174160 @default.
• W2892970757 cites W2083685405 @default.
• W2892970757 cites W2085741616 @default.
• W2892970757 cites W2087258417 @default.
• W2892970757 cites W2087505476 @default.
• W2892970757 cites W2087575813 @default.
• W2892970757 cites W2087853632 @default.
• W2892970757 cites W2088150403 @default.
• W2892970757 cites W2090409847 @default.
• W2892970757 cites W2090482806 @default.
• W2892970757 cites W2091512764 @default.
• W2892970757 cites W2098272988 @default.
• W2892970757 cites W2115149744 @default.
• W2892970757 cites W2116468715 @default.
• W2892970757 cites W2119534201 @default.
• W2892970757 cites W2122862649 @default.
• W2892970757 cites W2124354910 @default.
• W2892970757 cites W2127235616 @default.
• W2892970757 cites W2129321699 @default.
• W2892970757 cites W2131991755 @default.
• W2892970757 cites W2153325732 @default.
• W2892970757 cites W2159308938 @default.
• W2892970757 cites W2162323155 @default.
• W2892970757 cites W2167611139 @default.
• W2892970757 cites W2168014274 @default.
• W2892970757 cites W2169568834 @default.
• W2892970757 cites W2178916357 @default.
• W2892970757 cites W2197473678 @default.
• W2892970757 cites W2265483245 @default.
• W2892970757 cites W2290288831 @default.
• W2892970757 cites W2387268774 @default.
• W2892970757 cites W2408747271 @default.
• W2892970757 cites W2439550844 @default.
• W2892970757 cites W2542577540 @default.
• W2892970757 cites W2562021381 @default.
• W2892970757 cites W2955504961 @default.
• W2892970757 cites W4246374832 @default.
• W2892970757 cites W49370593 @default.
• W2892970757 doi "https://doi.org/10.1152/jn.00579.2018" @default.
• W2892970757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30256736" @default.
• W2892970757 hasPublicationYear "2018" @default.
• W2892970757 type Work @default.
• W2892970757 sameAs 2892970757 @default.
• W2892970757 citedByCount "10" @default.
• W2892970757 countsByYear W28929707572019 @default.
• W2892970757 countsByYear W28929707572021 @default.
• W2892970757 countsByYear W28929707572023 @default.
• W2892970757 crossrefType "journal-article" @default.

• next