FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892973298> ?p ?o ?g. }

• W2892973298 abstract "The pro-myelinating effects of leukemia inhibitory factor (LIF) and other cytokines of the gp130 family, including oncostatin M (OSM) and ciliary neurotrophic factor (CNTF), have long been known, but controversial results have also been reported. We recently overexpressed erythropoietin receptor (EPOR) in rat central glia-4 (CG4) oligodendrocyte progenitor cells (OPCs) to study the mechanisms mediating the pro-myelinating effects of erythropoietin (EPO). In this study, we investigated the effect of co-treatment with EPO and LIF. Gene expression in undifferentiated and differentiating CG4 cells in response to EPO and LIF was analysed by DNA microarrays and by RT-qPCR. Experiments were performed in biological replicates of N ≥ 4. Functional annotation and biological term enrichment was performed using DAVID (Database for Annotation, Visualization and Integrated Discovery). The gene-gene interaction network was visualised using STRING (Search Tool for the Retrieval of Interacting Genes). In CG4 cells treated with 10 ng/ml of EPO and 10 ng/ml of LIF, EPO-induced myelin oligodendrocyte glycoprotein (MOG) expression, measured at day 3 of differentiation, was inhibited ≥4-fold (N = 5, P < 0.001). Inhibition of EPO-induced MOG was also observed with OSM and CNTF. Analysis of the gene expression profile of CG4 differentiating cells treated for 20 h with EPO and LIF revealed LIF inhibition of EPO-induced genes involved in lipid transport and metabolism, previously identified as positive regulators of myelination in this system. In addition, among the genes induced by LIF, and not by differentiation or by EPO, the role of suppressor of cytokine signaling 3 (SOCS3) and toll like receptor 2 (TLR2) as negative regulators of myelination was further explored. LIF-induced SOCS3 was associated with MOG inhibition; Pam3, an agonist of TLR2, inhibited EPO-induced MOG expression, suggesting that TLR2 is functional and its activation decreases myelination. Cytokines of the gp130 family may have negative effects on myelination, depending on the cytokine environment." @default.
• W2892973298 created "2018-10-05" @default.
• W2892973298 creator A5019104450 @default.
• W2892973298 creator A5049977155 @default.
• W2892973298 creator A5053675346 @default.
• W2892973298 creator A5062400752 @default.
• W2892973298 creator A5068280856 @default.
• W2892973298 date "2018-09-27" @default.
• W2892973298 modified "2023-10-16" @default.
• W2892973298 title "Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes" @default.
• W2892973298 cites W1502312172 @default.
• W2892973298 cites W1503511302 @default.
• W2892973298 cites W1540861788 @default.
• W2892973298 cites W1552942919 @default.
• W2892973298 cites W1575907081 @default.
• W2892973298 cites W1673109277 @default.
• W2892973298 cites W1824670638 @default.
• W2892973298 cites W18558867 @default.
• W2892973298 cites W1979083661 @default.
• W2892973298 cites W1979299941 @default.
• W2892973298 cites W1982337563 @default.
• W2892973298 cites W1983419107 @default.
• W2892973298 cites W1984918825 @default.
• W2892973298 cites W1989128305 @default.
• W2892973298 cites W1999672519 @default.
• W2892973298 cites W2005297667 @default.
• W2892973298 cites W2008564037 @default.
• W2892973298 cites W2009537058 @default.
• W2892973298 cites W2010102541 @default.
• W2892973298 cites W2016313989 @default.
• W2892973298 cites W2024660851 @default.
• W2892973298 cites W2025308397 @default.
• W2892973298 cites W2031070508 @default.
• W2892973298 cites W2035657052 @default.
• W2892973298 cites W2046333658 @default.
• W2892973298 cites W2057617924 @default.
• W2892973298 cites W2059528602 @default.
• W2892973298 cites W2068969996 @default.
• W2892973298 cites W2074254290 @default.
• W2892973298 cites W2077702475 @default.
• W2892973298 cites W2081347853 @default.
• W2892973298 cites W2084976616 @default.
• W2892973298 cites W2088591814 @default.
• W2892973298 cites W2095040041 @default.
• W2892973298 cites W2097667540 @default.
• W2892973298 cites W2103255946 @default.
• W2892973298 cites W2103826332 @default.
• W2892973298 cites W2108005154 @default.
• W2892973298 cites W2111256919 @default.
• W2892973298 cites W2113716753 @default.
• W2892973298 cites W2115406568 @default.
• W2892973298 cites W2115437386 @default.
• W2892973298 cites W2117057692 @default.
• W2892973298 cites W2139314555 @default.
• W2892973298 cites W2142623408 @default.
• W2892973298 cites W2158217645 @default.
• W2892973298 cites W2165278466 @default.
• W2892973298 cites W2176522607 @default.
• W2892973298 cites W2259276487 @default.
• W2892973298 cites W2291129465 @default.
• W2892973298 cites W2315952645 @default.
• W2892973298 cites W2318484360 @default.
• W2892973298 cites W2326019584 @default.
• W2892973298 cites W2333701551 @default.
• W2892973298 cites W2418287889 @default.
• W2892973298 cites W2483156451 @default.
• W2892973298 cites W2588421639 @default.
• W2892973298 cites W2611350664 @default.
• W2892973298 cites W2626761667 @default.
• W2892973298 cites W2738907895 @default.
• W2892973298 cites W2750486105 @default.
• W2892973298 cites W2751637000 @default.
• W2892973298 cites W2759241443 @default.
• W2892973298 cites W2760972505 @default.
• W2892973298 cites W2761655880 @default.
• W2892973298 cites W2780766365 @default.
• W2892973298 cites W2786556478 @default.
• W2892973298 cites W2807662650 @default.
• W2892973298 cites W4242930333 @default.
• W2892973298 cites W43446693 @default.
• W2892973298 doi "https://doi.org/10.1186/s10020-018-0052-3" @default.
• W2892973298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6161334" @default.
• W2892973298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30261841" @default.
• W2892973298 hasPublicationYear "2018" @default.
• W2892973298 type Work @default.
• W2892973298 sameAs 2892973298 @default.
• W2892973298 citedByCount "6" @default.
• W2892973298 countsByYear W28929732982019 @default.
• W2892973298 countsByYear W28929732982020 @default.
• W2892973298 countsByYear W28929732982021 @default.
• W2892973298 crossrefType "journal-article" @default.
• W2892973298 hasAuthorship W2892973298A5019104450 @default.
• W2892973298 hasAuthorship W2892973298A5049977155 @default.
• W2892973298 hasAuthorship W2892973298A5053675346 @default.
• W2892973298 hasAuthorship W2892973298A5062400752 @default.
• W2892973298 hasAuthorship W2892973298A5068280856 @default.
• W2892973298 hasBestOaLocation W28929732981 @default.
• W2892973298 hasConcept C104317684 @default.
• W2892973298 hasConcept C106825092 @default.
• W2892973298 hasConcept C134018914 @default.

• next