FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892983422> ?p ?o ?g. }

• W2892983422 endingPage "187S" @default.
• W2892983422 startingPage "182S" @default.
• W2892983422 abstract "To perform a systematic review and network meta-analysis evaluating the efficacy and safety of low-molecular-weight heparins (LMWHs), vitamin K antagonists (VKAs), and direct-acting oral anticoagulants (DOACs) for the treatment of cancer-associated thrombosis (CAT). We searched MEDLINE, Cochrane Central Register of Controlled Trials, and conference abstracts through March 2018. Randomized controlled trials (RCTs) enrolling adults with CAT comparing 2 or more full-dose anticoagulants (LMWH, VKA, and DOAC) and evaluating recurrent venous thromboembolism (VTE), major bleeding, and/or all-cause mortality were included. Reviewers identified studies, extracted data, and assessed the quality of the evidence in duplicate. A frequentist network meta-analysis, which uses direct and indirect evidence to simultaneously compare multiple interventions, was performed using a random-effects approach. Results are reported as pooled relative risks (RRs) with 95% confidence intervals (CIs). We included 13 RCTs (n = 6292): 7 compared LMWHs with VKAs, 4 compared DOACs with VKAs, and 2 compared DOACs with LMWHs. The risk of recurrent VTE was significantly reduced by 28% and 54% with a DOAC compared to an LMWH and a VKA, respectively. Low-molecular-weight heparins significantly reduced the risk of recurrent VTE by 36% versus VKAs. The risk of major bleeding was 14% higher with DOACs compared to LMWHs and 15% and 25% lower with DOACs and LMWHs versus VKAs, although 95% CIs included unity for each. The risk of all-cause mortality appeared similar for all 3 comparisons (RR = 1.0 for each comparison). Direct-acting oral anticoagulants appeared superior in reducing recurrent VTE in patients with CAT compared to LMWH and VKAs, but an increased risk of major bleeding versus LMWH cannot be ruled out." @default.
• W2892983422 created "2018-10-05" @default.
• W2892983422 creator A5007420092 @default.
• W2892983422 creator A5013096466 @default.
• W2892983422 creator A5024212554 @default.
• W2892983422 creator A5032042660 @default.
• W2892983422 creator A5034742104 @default.
• W2892983422 creator A5044701600 @default.
• W2892983422 creator A5044789866 @default.
• W2892983422 date "2018-09-24" @default.
• W2892983422 modified "2023-10-14" @default.
• W2892983422 title "Anticoagulation for the Treatment of Cancer-Associated Thrombosis: A Systematic Review and Network Meta-Analysis of Randomized Trials" @default.
• W2892983422 cites W1617328014 @default.
• W2892983422 cites W1634950970 @default.
• W2892983422 cites W1982125716 @default.
• W2892983422 cites W1984833612 @default.
• W2892983422 cites W2007086823 @default.
• W2892983422 cites W2010481138 @default.
• W2892983422 cites W2033150840 @default.
• W2892983422 cites W2040496666 @default.
• W2892983422 cites W2054324054 @default.
• W2892983422 cites W2068237011 @default.
• W2892983422 cites W2070112905 @default.
• W2892983422 cites W2087879951 @default.
• W2892983422 cites W2098923148 @default.
• W2892983422 cites W2111139930 @default.
• W2892983422 cites W2111999709 @default.
• W2892983422 cites W2115019673 @default.
• W2892983422 cites W2125435699 @default.
• W2892983422 cites W2135936995 @default.
• W2892983422 cites W2138438886 @default.
• W2892983422 cites W2154738014 @default.
• W2892983422 cites W2157823046 @default.
• W2892983422 cites W2167494200 @default.
• W2892983422 cites W2170206601 @default.
• W2892983422 cites W2225937646 @default.
• W2892983422 cites W2471363772 @default.
• W2892983422 cites W2480010618 @default.
• W2892983422 cites W2519645937 @default.
• W2892983422 cites W2529469085 @default.
• W2892983422 cites W2573362725 @default.
• W2892983422 cites W2588681363 @default.
• W2892983422 cites W2764275027 @default.
• W2892983422 cites W2775434460 @default.
• W2892983422 cites W2793035957 @default.
• W2892983422 cites W2795588879 @default.
• W2892983422 cites W2802130786 @default.
• W2892983422 doi "https://doi.org/10.1177/1076029618800792" @default.
• W2892983422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6714836" @default.
• W2892983422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30244595" @default.
• W2892983422 hasPublicationYear "2018" @default.
• W2892983422 type Work @default.
• W2892983422 sameAs 2892983422 @default.
• W2892983422 citedByCount "29" @default.
• W2892983422 countsByYear W28929834222018 @default.
• W2892983422 countsByYear W28929834222019 @default.
• W2892983422 countsByYear W28929834222020 @default.
• W2892983422 countsByYear W28929834222021 @default.
• W2892983422 countsByYear W28929834222022 @default.
• W2892983422 countsByYear W28929834222023 @default.
• W2892983422 crossrefType "journal-article" @default.
• W2892983422 hasAuthorship W2892983422A5007420092 @default.
• W2892983422 hasAuthorship W2892983422A5013096466 @default.
• W2892983422 hasAuthorship W2892983422A5024212554 @default.
• W2892983422 hasAuthorship W2892983422A5032042660 @default.
• W2892983422 hasAuthorship W2892983422A5034742104 @default.
• W2892983422 hasAuthorship W2892983422A5044701600 @default.
• W2892983422 hasAuthorship W2892983422A5044789866 @default.
• W2892983422 hasBestOaLocation W28929834221 @default.
• W2892983422 hasConcept C126322002 @default.
• W2892983422 hasConcept C168563851 @default.
• W2892983422 hasConcept C177713679 @default.
• W2892983422 hasConcept C2776301958 @default.
• W2892983422 hasConcept C2776884760 @default.
• W2892983422 hasConcept C2779161974 @default.
• W2892983422 hasConcept C2780868729 @default.
• W2892983422 hasConcept C44249647 @default.
• W2892983422 hasConcept C71924100 @default.
• W2892983422 hasConcept C82789193 @default.
• W2892983422 hasConcept C95190672 @default.
• W2892983422 hasConceptScore W2892983422C126322002 @default.
• W2892983422 hasConceptScore W2892983422C168563851 @default.
• W2892983422 hasConceptScore W2892983422C177713679 @default.
• W2892983422 hasConceptScore W2892983422C2776301958 @default.
• W2892983422 hasConceptScore W2892983422C2776884760 @default.
• W2892983422 hasConceptScore W2892983422C2779161974 @default.
• W2892983422 hasConceptScore W2892983422C2780868729 @default.
• W2892983422 hasConceptScore W2892983422C44249647 @default.
• W2892983422 hasConceptScore W2892983422C71924100 @default.
• W2892983422 hasConceptScore W2892983422C82789193 @default.
• W2892983422 hasConceptScore W2892983422C95190672 @default.
• W2892983422 hasIssue "9_suppl" @default.
• W2892983422 hasLocation W28929834221 @default.
• W2892983422 hasLocation W28929834222 @default.
• W2892983422 hasLocation W28929834223 @default.
• W2892983422 hasLocation W28929834224 @default.
• W2892983422 hasOpenAccess W2892983422 @default.
• W2892983422 hasPrimaryLocation W28929834221 @default.

• next