FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892987557> ?p ?o ?g. }

• W2892987557 endingPage "1219" @default.
• W2892987557 startingPage "1201" @default.
• W2892987557 abstract "This paper presents the development of a vascularized breast tumor and healthy or tumorigenic liver microenvironments-on-a-chip connected in series. This is the first description of a vascularized multi tissue-on-a-chip microenvironment for modeling cancerous breast and cancerous/healthy liver microenvironments, to allow for the study of dynamic and spatial transport of particles. This device enables the dynamic determination of vessel permeability, the measurement of drug and nanoparticle transport, and the assessment of the associated efficacy and toxicity to the liver. The platform is utilized to determine the effect of particle size on the spatiotemporal diffusion of particles through each microenvironment, both independently and in response to the circulation of particles in varying sequences of microenvironments. The results show that when breast cancer cells were cultured in the microenvironments they had a 2.62-fold higher vessel porosity relative to vessels within healthy liver microenvironments. Hence, the permeability of the tumor microenvironment increased by 2.35- and 2.77-fold compared with a healthy liver for small and large particles, respectively. The extracellular matrix accumulation rate of larger particles was 2.57-fold lower than smaller particles in a healthy liver. However, the accumulation rate was 5.57-fold greater in the breast tumor microenvironment. These results are in agreement with comparable in vivo studies. Ultimately, the platform could be utilized to determine the impact of the tissue or tumor microenvironment, or drug and nanoparticle properties, on transport, efficacy, selectivity, and toxicity in a dynamic, and high-throughput manner for use in treatment optimization." @default.
• W2892987557 created "2018-10-05" @default.
• W2892987557 creator A5007550818 @default.
• W2892987557 creator A5027619317 @default.
• W2892987557 creator A5047166582 @default.
• W2892987557 creator A5082444529 @default.
• W2892987557 creator A5086942579 @default.
• W2892987557 date "2019-02-13" @default.
• W2892987557 modified "2023-10-16" @default.
• W2892987557 title "In vitro vascularized liver and tumor tissue microenvironments on a chip for dynamic determination of nanoparticle transport and toxicity" @default.
• W2892987557 cites W1589451590 @default.
• W2892987557 cites W1592898600 @default.
• W2892987557 cites W1603392814 @default.
• W2892987557 cites W1967221930 @default.
• W2892987557 cites W1971801942 @default.
• W2892987557 cites W1973078202 @default.
• W2892987557 cites W1993016627 @default.
• W2892987557 cites W1993874973 @default.
• W2892987557 cites W1996994737 @default.
• W2892987557 cites W2006013671 @default.
• W2892987557 cites W2007987850 @default.
• W2892987557 cites W2009105978 @default.
• W2892987557 cites W2010491849 @default.
• W2892987557 cites W2023430279 @default.
• W2892987557 cites W2035508730 @default.
• W2892987557 cites W2037780637 @default.
• W2892987557 cites W2044264198 @default.
• W2892987557 cites W2047024786 @default.
• W2892987557 cites W2055384999 @default.
• W2892987557 cites W2055759462 @default.
• W2892987557 cites W2057723124 @default.
• W2892987557 cites W2061834863 @default.
• W2892987557 cites W2063033586 @default.
• W2892987557 cites W2064252921 @default.
• W2892987557 cites W2065683487 @default.
• W2892987557 cites W2073631436 @default.
• W2892987557 cites W2075003434 @default.
• W2892987557 cites W2075280869 @default.
• W2892987557 cites W2076081218 @default.
• W2892987557 cites W2077045805 @default.
• W2892987557 cites W2077967017 @default.
• W2892987557 cites W2081560083 @default.
• W2892987557 cites W2083710155 @default.
• W2892987557 cites W2088004044 @default.
• W2892987557 cites W2090136117 @default.
• W2892987557 cites W2093082279 @default.
• W2892987557 cites W2099052265 @default.
• W2892987557 cites W2100627342 @default.
• W2892987557 cites W2102075858 @default.
• W2892987557 cites W2108044029 @default.
• W2892987557 cites W2112791462 @default.
• W2892987557 cites W2126163864 @default.
• W2892987557 cites W2133135568 @default.
• W2892987557 cites W2133379217 @default.
• W2892987557 cites W2137521271 @default.
• W2892987557 cites W2139304435 @default.
• W2892987557 cites W2139424714 @default.
• W2892987557 cites W2140279988 @default.
• W2892987557 cites W2143463421 @default.
• W2892987557 cites W2144000876 @default.
• W2892987557 cites W2149283799 @default.
• W2892987557 cites W2149672704 @default.
• W2892987557 cites W2150146274 @default.
• W2892987557 cites W2161499637 @default.
• W2892987557 cites W2161771297 @default.
• W2892987557 cites W2165269428 @default.
• W2892987557 cites W2168700995 @default.
• W2892987557 cites W2172247815 @default.
• W2892987557 cites W2325212255 @default.
• W2892987557 cites W2344644350 @default.
• W2892987557 cites W2401869278 @default.
• W2892987557 cites W2407836966 @default.
• W2892987557 cites W2461514389 @default.
• W2892987557 cites W2465783432 @default.
• W2892987557 cites W2475530256 @default.
• W2892987557 cites W2565304193 @default.
• W2892987557 cites W2586976801 @default.
• W2892987557 cites W2590837630 @default.
• W2892987557 cites W2748363346 @default.
• W2892987557 cites W2781525129 @default.
• W2892987557 cites W2810086534 @default.
• W2892987557 doi "https://doi.org/10.1002/bit.26919" @default.
• W2892987557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30636289" @default.
• W2892987557 hasPublicationYear "2019" @default.
• W2892987557 type Work @default.
• W2892987557 sameAs 2892987557 @default.
• W2892987557 citedByCount "47" @default.
• W2892987557 countsByYear W28929875572018 @default.
• W2892987557 countsByYear W28929875572019 @default.
• W2892987557 countsByYear W28929875572020 @default.
• W2892987557 countsByYear W28929875572021 @default.
• W2892987557 countsByYear W28929875572022 @default.
• W2892987557 countsByYear W28929875572023 @default.
• W2892987557 crossrefType "journal-article" @default.
• W2892987557 hasAuthorship W2892987557A5007550818 @default.
• W2892987557 hasAuthorship W2892987557A5027619317 @default.
• W2892987557 hasAuthorship W2892987557A5047166582 @default.
• W2892987557 hasAuthorship W2892987557A5082444529 @default.

• next