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- W2892996644 endingPage "2954" @default.
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- W2892996644 abstract "Significance Voltage-gated sodium channels play a central role in cellular excitability and are key targets for drug development. Recent breakthroughs in high-resolution cryo-electron microscopy protein structure determination, Rosetta computational protein structure modeling, and multimicrosecond molecular dynamics simulations are empowering advances in structural biology to study the atomistic details of channel−drug interactions. We used Rosetta structural computational modeling and molecular dynamics simulations to study the interactions of antiarrhythmic and local anesthetic drugs with cardiac sodium channel. Our results provide crucial atomic-scale mechanistic insights into the channel–drug interactions, necessary for the rational design of novel modulators of the human cardiac sodium channel to be used for the treatment of cardiac arrhythmias." @default.
- W2892996644 created "2018-10-05" @default.
- W2892996644 creator A5031310158 @default.
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- W2892996644 creator A5051376606 @default.
- W2892996644 creator A5055449255 @default.
- W2892996644 creator A5087293334 @default.
- W2892996644 date "2019-02-06" @default.
- W2892996644 modified "2023-10-16" @default.
- W2892996644 title "Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel" @default.
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- W2892996644 doi "https://doi.org/10.1073/pnas.1817446116" @default.
- W2892996644 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6386684" @default.
- W2892996644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30728299" @default.
- W2892996644 hasPublicationYear "2019" @default.