FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893002225> ?p ?o ?g. }

• W2893002225 endingPage "e1507" @default.
• W2893002225 startingPage "e1498" @default.
• W2893002225 abstract "Objective The aim of this study was to determine in a systematic manner if the C9orf72 phenotype might extend beyond frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) to include psychiatric disease. Methods A validated semistructured family history interview was conducted in a large cohort of patients with FTD and ALS (n = 89), with and without the C9orf72 expansion (n = 29 and n = 60, respectively), encompassing 1,414 first- and second-degree relatives. Statistical analyses used both the hazard ratio (HR) and the relative risk ratio to determine the risk profiles within families. Results A significant HR of 4.9 (95% confidence interval [CI]: 1.9–13.9, p = 0.003) confirmed a higher probability of developing schizophrenia for relatives of C9orf72 carriers compared with noncarriers. In addition, 8 relatives of C9orf72 carriers experienced an episode of late-onset psychosis unrelated to schizophrenia, in comparison to one noncarrier (HR = 17.9, 95% CI: 2.2–143.2, p = 0.007). The probability of suicide was also significantly higher for family members of C9orf72 carriers (HR = 2.7, 95% CI: 1.2–6.2, p = 0.02). An HR of 2.7 (95% CI: 1.1–6.9, p = 0.03) indicated a higher probability of autism spectrum disorder (ASD) in family members of C9orf72 carriers, and this risk extended to FTD. Furthermore, there was a positive association between psychosis in probands and mental health disorders, including ASD in their family members ( p = 0.04). Conclusion Overall, the results from this study suggest that a psychiatric phenotype exists within C9orf72 kindreds. Further studies should attempt to delineate the risk of psychiatric disorders in C9orf72 kindreds to aid in clinical decision making, particularly regarding genetic counseling, through collaborations between neurology and psychiatry." @default.
• W2893002225 created "2018-10-05" @default.
• W2893002225 creator A5020959090 @default.
• W2893002225 creator A5047141421 @default.
• W2893002225 creator A5054956123 @default.
• W2893002225 creator A5060424866 @default.
• W2893002225 creator A5069129362 @default.
• W2893002225 creator A5070438668 @default.
• W2893002225 date "2018-09-26" @default.
• W2893002225 modified "2023-10-14" @default.
• W2893002225 title "Psychiatric disorders in <i>C9orf72</i> kindreds" @default.
• W2893002225 cites W1608778639 @default.
• W2893002225 cites W1968754624 @default.
• W2893002225 cites W1969655797 @default.
• W2893002225 cites W1969669833 @default.
• W2893002225 cites W1985062203 @default.
• W2893002225 cites W1987511724 @default.
• W2893002225 cites W1988104043 @default.
• W2893002225 cites W1995714006 @default.
• W2893002225 cites W2001862080 @default.
• W2893002225 cites W2002012536 @default.
• W2893002225 cites W2015852104 @default.
• W2893002225 cites W2029303977 @default.
• W2893002225 cites W2032586089 @default.
• W2893002225 cites W2057964653 @default.
• W2893002225 cites W2077912602 @default.
• W2893002225 cites W2090849810 @default.
• W2893002225 cites W2101334128 @default.
• W2893002225 cites W2128030851 @default.
• W2893002225 cites W2132629018 @default.
• W2893002225 cites W2134318672 @default.
• W2893002225 cites W2137404280 @default.
• W2893002225 cites W2144535302 @default.
• W2893002225 cites W2150523249 @default.
• W2893002225 cites W2161938104 @default.
• W2893002225 cites W2163408642 @default.
• W2893002225 cites W2166497992 @default.
• W2893002225 cites W2225889451 @default.
• W2893002225 cites W2413042865 @default.
• W2893002225 cites W2532112812 @default.
• W2893002225 cites W2766730769 @default.
• W2893002225 cites W4240843895 @default.
• W2893002225 cites W4247665917 @default.
• W2893002225 doi "https://doi.org/10.1212/wnl.0000000000006344" @default.
• W2893002225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30258023" @default.
• W2893002225 hasPublicationYear "2018" @default.
• W2893002225 type Work @default.
• W2893002225 sameAs 2893002225 @default.
• W2893002225 citedByCount "66" @default.
• W2893002225 countsByYear W28930022252019 @default.
• W2893002225 countsByYear W28930022252020 @default.
• W2893002225 countsByYear W28930022252021 @default.
• W2893002225 countsByYear W28930022252022 @default.
• W2893002225 countsByYear W28930022252023 @default.
• W2893002225 crossrefType "journal-article" @default.
• W2893002225 hasAuthorship W2893002225A5020959090 @default.
• W2893002225 hasAuthorship W2893002225A5047141421 @default.
• W2893002225 hasAuthorship W2893002225A5054956123 @default.
• W2893002225 hasAuthorship W2893002225A5060424866 @default.
• W2893002225 hasAuthorship W2893002225A5069129362 @default.
• W2893002225 hasAuthorship W2893002225A5070438668 @default.
• W2893002225 hasConcept C104317684 @default.
• W2893002225 hasConcept C118552586 @default.
• W2893002225 hasConcept C126322002 @default.
• W2893002225 hasConcept C15744967 @default.
• W2893002225 hasConcept C188997412 @default.
• W2893002225 hasConcept C207103383 @default.
• W2893002225 hasConcept C2776412080 @default.
• W2893002225 hasConcept C2777898937 @default.
• W2893002225 hasConcept C2778641062 @default.
• W2893002225 hasConcept C2779134260 @default.
• W2893002225 hasConcept C2779483572 @default.
• W2893002225 hasConcept C2779727114 @default.
• W2893002225 hasConcept C2780596555 @default.
• W2893002225 hasConcept C2781179581 @default.
• W2893002225 hasConcept C44249647 @default.
• W2893002225 hasConcept C501734568 @default.
• W2893002225 hasConcept C54355233 @default.
• W2893002225 hasConcept C70410870 @default.
• W2893002225 hasConcept C71924100 @default.
• W2893002225 hasConcept C72563966 @default.
• W2893002225 hasConcept C86803240 @default.
• W2893002225 hasConceptScore W2893002225C104317684 @default.
• W2893002225 hasConceptScore W2893002225C118552586 @default.
• W2893002225 hasConceptScore W2893002225C126322002 @default.
• W2893002225 hasConceptScore W2893002225C15744967 @default.
• W2893002225 hasConceptScore W2893002225C188997412 @default.
• W2893002225 hasConceptScore W2893002225C207103383 @default.
• W2893002225 hasConceptScore W2893002225C2776412080 @default.
• W2893002225 hasConceptScore W2893002225C2777898937 @default.
• W2893002225 hasConceptScore W2893002225C2778641062 @default.
• W2893002225 hasConceptScore W2893002225C2779134260 @default.
• W2893002225 hasConceptScore W2893002225C2779483572 @default.
• W2893002225 hasConceptScore W2893002225C2779727114 @default.
• W2893002225 hasConceptScore W2893002225C2780596555 @default.
• W2893002225 hasConceptScore W2893002225C2781179581 @default.
• W2893002225 hasConceptScore W2893002225C44249647 @default.
• W2893002225 hasConceptScore W2893002225C501734568 @default.

• next