FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893009136> ?p ?o ?g. }

• W2893009136 abstract "Background Clinical outcome has improved in systemic lupus erythematosus (SLE) and thus, early management of comorbidities like cardiovascular disease and osteoporosis has become highly important. In this disease, osteoporotic risk factors such as female gender, early onset of disease leading to long disease duration, high degree of systemic inflammation, high frequencies of glucocorticoid usage often at higher doses, and chronic fatigue or pain compromising physical activities are often present in combination.1 Rh-GIOP (NCT02719314) is an ongoing prospective study monitoring glucocorticoid (GC)-induced osteoporosis of rheumatic patients, established in 2015 at the Charite University Hospital. To date, the database comprises clinical data and bone mineral density data measured by dual x-ray absorptiometry (DXA) of 592 patients with inflammatory rheumatic diseases. Objectives To quantify bone mineral density and fractures in SLE patients. Methods Bone mineral density (BMD) data of SLE patients as measured by dual x-ray absorptiometry (DXA) were analysed with regard to their relation to detailed clinical data. Results 43 female and 6 male SLE patients aged between 20 and 77 years (mean: 46.31 years) were assessed by DXA (all of Caucasian ethnicity, mean disease duration: 15.49 years; 61% denied any physical activity). SLE medication included glucocorticoids (93.9%; mean cumulative dose: 25.5 g), antimalarials (67.3%), azathioprine (30.6%), mycophenolate-mofetil acid (22.4%), belimumab (16.3%), cyclophosphamide (10.2%) and methotrexate (8.1%). In 26 (60,5%) of all studied SLE patients, 36 (92.3%) peripheral and 3 (7.7%) vertebral fractures were recorded. Notably, 6 of these patients with fractures were younger than 30 and only 4 older than 60 years. 10 of all 39 fractures (25.6%) were low-trauma fractures. Of note, 11/26 patients (42.3%) with fractures had a normal BMD, 9/26 (34.6%) osteopenia and 6/26 (23.7%) osteoporosis, while only 4 (15.4%) of them initially received anti-osteoporotic medication. Conclusions There is a high occurrence of peripheral fractures in SLE. Moreover, 4 out of 10 SLE patients developed fractures despite a normal BMD, stressing that this parameter is of limited value for correctly identifying the fracture risk in SLE. The analysis of a larger number of patients and in-depth analyses are necessary to improve management of osteoporosis and to better prevent fractures in SLE patients. Reference [1] “Bone Disease in Connective Tissue Disease/Systemic Lupus Erythematosus.” Bultink IEM. Calcif Tissue Int. 2017Sep 12 Disclosure of Interest R. Biesen Grant/research support from: Amgen, BMS, Celgene, Generic Assays GSK, Horizon, medac, Mundipharma, Pfizer and Roche, E. Wiebe Grant/research support from: Amgen, BMS, Celgene, Generic Assays GSK, Horizon, medac, Mundipharma, Pfizer and Roche, D. Freier Grant/research support from: Amgen, BMS, Celgene, Generic Assays GSK, Horizon, medac, Mundipharma, Pfizer and Roche, K. Zeiner Grant/research support from: Amgen, BMS, Celgene, Generic Assays GSK, Horizon, medac, Mundipharma, Pfizer and Roche, U. Schneider: None declared, T. Alexander: None declared, F. Hiepe: None declared, F. Buttgereit Grant/research support from: Amgen, BMS, Celgene, Generic Assays GSK, Horizon, medac, Mundipharma, Pfizer and Roche" @default.
• W2893009136 created "2018-10-05" @default.
• W2893009136 creator A5014912299 @default.
• W2893009136 creator A5025690932 @default.
• W2893009136 creator A5041111430 @default.
• W2893009136 creator A5054910144 @default.
• W2893009136 creator A5056307412 @default.
• W2893009136 creator A5058094909 @default.
• W2893009136 creator A5064112799 @default.
• W2893009136 creator A5087622897 @default.
• W2893009136 date "2018-06-01" @default.
• W2893009136 modified "2023-10-04" @default.
• W2893009136 title "AB0619 Many peripheral fractures despite normal bone mineral densityin caucasian sle patients" @default.
• W2893009136 doi "https://doi.org/10.1136/annrheumdis-2018-eular.3429" @default.
• W2893009136 hasPublicationYear "2018" @default.
• W2893009136 type Work @default.
• W2893009136 sameAs 2893009136 @default.
• W2893009136 citedByCount "0" @default.
• W2893009136 crossrefType "proceedings-article" @default.
• W2893009136 hasAuthorship W2893009136A5014912299 @default.
• W2893009136 hasAuthorship W2893009136A5025690932 @default.
• W2893009136 hasAuthorship W2893009136A5041111430 @default.
• W2893009136 hasAuthorship W2893009136A5054910144 @default.
• W2893009136 hasAuthorship W2893009136A5056307412 @default.
• W2893009136 hasAuthorship W2893009136A5058094909 @default.
• W2893009136 hasAuthorship W2893009136A5064112799 @default.
• W2893009136 hasAuthorship W2893009136A5087622897 @default.
• W2893009136 hasBestOaLocation W28930091361 @default.
• W2893009136 hasConcept C126322002 @default.
• W2893009136 hasConcept C2776541429 @default.
• W2893009136 hasConcept C2776694085 @default.
• W2893009136 hasConcept C2776755627 @default.
• W2893009136 hasConcept C2776760755 @default.
• W2893009136 hasConcept C2776886416 @default.
• W2893009136 hasConcept C2778720950 @default.
• W2893009136 hasConcept C2779134260 @default.
• W2893009136 hasConcept C2779329777 @default.
• W2893009136 hasConcept C71924100 @default.
• W2893009136 hasConcept C90924648 @default.
• W2893009136 hasConceptScore W2893009136C126322002 @default.
• W2893009136 hasConceptScore W2893009136C2776541429 @default.
• W2893009136 hasConceptScore W2893009136C2776694085 @default.
• W2893009136 hasConceptScore W2893009136C2776755627 @default.
• W2893009136 hasConceptScore W2893009136C2776760755 @default.
• W2893009136 hasConceptScore W2893009136C2776886416 @default.
• W2893009136 hasConceptScore W2893009136C2778720950 @default.
• W2893009136 hasConceptScore W2893009136C2779134260 @default.
• W2893009136 hasConceptScore W2893009136C2779329777 @default.
• W2893009136 hasConceptScore W2893009136C71924100 @default.
• W2893009136 hasConceptScore W2893009136C90924648 @default.
• W2893009136 hasLocation W28930091361 @default.
• W2893009136 hasOpenAccess W2893009136 @default.
• W2893009136 hasPrimaryLocation W28930091361 @default.
• W2893009136 isParatext "false" @default.
• W2893009136 isRetracted "false" @default.
• W2893009136 magId "2893009136" @default.
• W2893009136 workType "article" @default.