FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893012274> ?p ?o ?g. }

• W2893012274 endingPage "978" @default.
• W2893012274 startingPage "971" @default.
• W2893012274 abstract "Once-daily lenvatinib 24 mg is the approved dose for radioiodine-refractory differentiated thyroid cancer. In a phase 3 trial with lenvatinib, the starting dose of 24 mg was associated with a relatively high incidence of adverse events that required dose reductions. We used an exposure–response model to investigate the risk–benefit of different dosing regimens for lenvatinib. A population pharmacokinetics/pharmacodynamics modeling analysis was used to simulate the potential benefit of lower starting doses to retain efficacy with improved safety. The seven lenvatinib regimens tested were: 24 mg; and 20 mg, 18 mg, and 14 mg, all with or without up-titration to 24 mg. Exposure–response models for efficacy and safety were created using a 24-week time course. The approved dose of lenvatinib at 24 mg, predicted the best efficacy. However, the lenvatinib dosing regimens of 14 mg with up-titration or 18 mg without up-titration potentially provides comparable efficacy (objective response rate at 24 weeks) and a better safety profile. Treatment with lenvatinib at starting doses lower than the approved once-daily 24 mg dose could provide comparable antitumor efficacy and a similar or better safety profile. Based on the results from this modeling and simulation study, a comparator dose of lenvatinib 18 mg without up-titration was selected for evaluation in a clinical trial." @default.
• W2893012274 created "2018-10-05" @default.
• W2893012274 creator A5022334220 @default.
• W2893012274 creator A5050337650 @default.
• W2893012274 creator A5056255214 @default.
• W2893012274 creator A5056514511 @default.
• W2893012274 creator A5057800678 @default.
• W2893012274 creator A5074010041 @default.
• W2893012274 date "2018-09-22" @default.
• W2893012274 modified "2023-10-03" @default.
• W2893012274 title "Exposure–response analysis and simulation of lenvatinib safety and efficacy in patients with radioiodine-refractory differentiated thyroid cancer" @default.
• W2893012274 cites W1571830205 @default.
• W2893012274 cites W1967792499 @default.
• W2893012274 cites W2019294726 @default.
• W2893012274 cites W2019607817 @default.
• W2893012274 cites W2025066188 @default.
• W2893012274 cites W2086128314 @default.
• W2893012274 cites W2094109552 @default.
• W2893012274 cites W2110643890 @default.
• W2893012274 cites W2131368580 @default.
• W2893012274 cites W2133195786 @default.
• W2893012274 cites W2281400124 @default.
• W2893012274 cites W2291457300 @default.
• W2893012274 cites W2319048980 @default.
• W2893012274 doi "https://doi.org/10.1007/s00280-018-3687-4" @default.
• W2893012274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6267706" @default.
• W2893012274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30244318" @default.
• W2893012274 hasPublicationYear "2018" @default.
• W2893012274 type Work @default.
• W2893012274 sameAs 2893012274 @default.
• W2893012274 citedByCount "16" @default.
• W2893012274 countsByYear W28930122742019 @default.
• W2893012274 countsByYear W28930122742020 @default.
• W2893012274 countsByYear W28930122742021 @default.
• W2893012274 countsByYear W28930122742022 @default.
• W2893012274 countsByYear W28930122742023 @default.
• W2893012274 crossrefType "journal-article" @default.
• W2893012274 hasAuthorship W2893012274A5022334220 @default.
• W2893012274 hasAuthorship W2893012274A5050337650 @default.
• W2893012274 hasAuthorship W2893012274A5056255214 @default.
• W2893012274 hasAuthorship W2893012274A5056514511 @default.
• W2893012274 hasAuthorship W2893012274A5057800678 @default.
• W2893012274 hasAuthorship W2893012274A5074010041 @default.
• W2893012274 hasBestOaLocation W28930122741 @default.
• W2893012274 hasConcept C111113717 @default.
• W2893012274 hasConcept C112705442 @default.
• W2893012274 hasConcept C121332964 @default.
• W2893012274 hasConcept C121608353 @default.
• W2893012274 hasConcept C126322002 @default.
• W2893012274 hasConcept C142424586 @default.
• W2893012274 hasConcept C143998085 @default.
• W2893012274 hasConcept C197934379 @default.
• W2893012274 hasConcept C2776264508 @default.
• W2893012274 hasConcept C2777288759 @default.
• W2893012274 hasConcept C2779761222 @default.
• W2893012274 hasConcept C2908647359 @default.
• W2893012274 hasConcept C535046627 @default.
• W2893012274 hasConcept C71924100 @default.
• W2893012274 hasConcept C87355193 @default.
• W2893012274 hasConcept C98274493 @default.
• W2893012274 hasConcept C99454951 @default.
• W2893012274 hasConceptScore W2893012274C111113717 @default.
• W2893012274 hasConceptScore W2893012274C112705442 @default.
• W2893012274 hasConceptScore W2893012274C121332964 @default.
• W2893012274 hasConceptScore W2893012274C121608353 @default.
• W2893012274 hasConceptScore W2893012274C126322002 @default.
• W2893012274 hasConceptScore W2893012274C142424586 @default.
• W2893012274 hasConceptScore W2893012274C143998085 @default.
• W2893012274 hasConceptScore W2893012274C197934379 @default.
• W2893012274 hasConceptScore W2893012274C2776264508 @default.
• W2893012274 hasConceptScore W2893012274C2777288759 @default.
• W2893012274 hasConceptScore W2893012274C2779761222 @default.
• W2893012274 hasConceptScore W2893012274C2908647359 @default.
• W2893012274 hasConceptScore W2893012274C535046627 @default.
• W2893012274 hasConceptScore W2893012274C71924100 @default.
• W2893012274 hasConceptScore W2893012274C87355193 @default.
• W2893012274 hasConceptScore W2893012274C98274493 @default.
• W2893012274 hasConceptScore W2893012274C99454951 @default.
• W2893012274 hasFunder F4320322148 @default.
• W2893012274 hasIssue "6" @default.
• W2893012274 hasLocation W28930122741 @default.
• W2893012274 hasLocation W28930122742 @default.
• W2893012274 hasLocation W28930122743 @default.
• W2893012274 hasLocation W28930122744 @default.
• W2893012274 hasOpenAccess W2893012274 @default.
• W2893012274 hasPrimaryLocation W28930122741 @default.
• W2893012274 hasRelatedWork W2004325424 @default.
• W2893012274 hasRelatedWork W2021319218 @default.
• W2893012274 hasRelatedWork W2227061539 @default.
• W2893012274 hasRelatedWork W2254638634 @default.
• W2893012274 hasRelatedWork W2543342198 @default.
• W2893012274 hasRelatedWork W2550344429 @default.
• W2893012274 hasRelatedWork W2992709639 @default.
• W2893012274 hasRelatedWork W3021369409 @default.
• W2893012274 hasRelatedWork W3174177415 @default.
• W2893012274 hasRelatedWork W4212898924 @default.
• W2893012274 hasVolume "82" @default.
• W2893012274 isParatext "false" @default.

• next