Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893016895> ?p ?o ?g. }
- W2893016895 abstract "Conformationally defective cystic fibrosis transmembrane conductance regulator (CFTR) including rescued ΔF508-CFTR is rapidly eliminated from the plasma membrane (PM) even in the presence of a CFTR corrector and potentiator, limiting the therapeutic effort of the combination therapy. CFTR elimination from the PM is determined by the conformation-dependent ubiquitination as a part of the peripheral quality control (PQC) mechanism. Recently, the molecular machineries responsible for the CFTR PQC mechanism which includes molecular chaperones and ubiquitination enzymes have been revealed. This review summarizes the molecular mechanism of the CFTR PQC and discusses the possibility that the peripheral ubiquitination mechanism becomes a novel drug target to develop the CFTR stabilizer as a novel class of CFTR modulator." @default.
- W2893016895 created "2018-10-05" @default.
- W2893016895 creator A5002765176 @default.
- W2893016895 creator A5091593293 @default.
- W2893016895 date "2018-09-27" @default.
- W2893016895 modified "2023-10-14" @default.
- W2893016895 title "Peripheral Protein Quality Control as a Novel Drug Target for CFTR Stabilizer" @default.
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