FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893018960> ?p ?o ?g. }

• W2893018960 endingPage "10314" @default.
• W2893018960 startingPage "10311" @default.
• W2893018960 abstract "Significance Thymidylate synthase (TSase) is one of the prime anticancer targets, as it generates the sole de novo source of thymidylate, a unique precursor for DNA. Fluoropyrimidines and antifolates inhibiting TSase pathways are not only components of the most widely used therapeutic regimens but also highly toxic agents leading to acquired resistance in tumor cells. To provide fresh mechanistic insight to TSase-targeted drug design, we used a combination of experiments, kinetic modeling, and quantum mechanics/molecular mechanics (QM/MM) calculations to discover formation of unexpected noncovalent intermediates prevailing in the catalysis and overstabilized covalent species corresponding to a parallel reaction pathway. These findings challenge the traditional chemical path of this enzyme and offer drug targets." @default.
• W2893018960 created "2018-10-05" @default.
• W2893018960 creator A5002277303 @default.
• W2893018960 creator A5010894256 @default.
• W2893018960 creator A5040981658 @default.
• W2893018960 creator A5042711695 @default.
• W2893018960 creator A5087102638 @default.
• W2893018960 date "2018-09-24" @default.
• W2893018960 modified "2023-10-11" @default.
• W2893018960 title "Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools" @default.
• W2893018960 cites W1526908156 @default.
• W2893018960 cites W1969440342 @default.
• W2893018960 cites W1974303275 @default.
• W2893018960 cites W1980335188 @default.
• W2893018960 cites W1986813139 @default.
• W2893018960 cites W1991619302 @default.
• W2893018960 cites W1996927744 @default.
• W2893018960 cites W2010357185 @default.
• W2893018960 cites W2027446106 @default.
• W2893018960 cites W2034346214 @default.
• W2893018960 cites W2034563090 @default.
• W2893018960 cites W2060311941 @default.
• W2893018960 cites W2076295329 @default.
• W2893018960 cites W2087432098 @default.
• W2893018960 cites W2176123637 @default.
• W2893018960 cites W2323765605 @default.
• W2893018960 cites W2469559139 @default.
• W2893018960 doi "https://doi.org/10.1073/pnas.1811059115" @default.
• W2893018960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6187185" @default.
• W2893018960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30249644" @default.
• W2893018960 hasPublicationYear "2018" @default.
• W2893018960 type Work @default.
• W2893018960 sameAs 2893018960 @default.
• W2893018960 citedByCount "7" @default.
• W2893018960 countsByYear W28930189602019 @default.
• W2893018960 countsByYear W28930189602020 @default.
• W2893018960 countsByYear W28930189602021 @default.
• W2893018960 countsByYear W28930189602022 @default.
• W2893018960 countsByYear W28930189602023 @default.
• W2893018960 crossrefType "journal-article" @default.
• W2893018960 hasAuthorship W2893018960A5002277303 @default.
• W2893018960 hasAuthorship W2893018960A5010894256 @default.
• W2893018960 hasAuthorship W2893018960A5040981658 @default.
• W2893018960 hasAuthorship W2893018960A5042711695 @default.
• W2893018960 hasAuthorship W2893018960A5087102638 @default.
• W2893018960 hasBestOaLocation W28930189601 @default.
• W2893018960 hasConcept C112887158 @default.
• W2893018960 hasConcept C121608353 @default.
• W2893018960 hasConcept C123321153 @default.
• W2893018960 hasConcept C137277065 @default.
• W2893018960 hasConcept C147597530 @default.
• W2893018960 hasConcept C178790620 @default.
• W2893018960 hasConcept C180577832 @default.
• W2893018960 hasConcept C181199279 @default.
• W2893018960 hasConcept C185592680 @default.
• W2893018960 hasConcept C21951064 @default.
• W2893018960 hasConcept C25057246 @default.
• W2893018960 hasConcept C2780456651 @default.
• W2893018960 hasConcept C32909587 @default.
• W2893018960 hasConcept C54355233 @default.
• W2893018960 hasConcept C55493867 @default.
• W2893018960 hasConcept C59593255 @default.
• W2893018960 hasConcept C70721500 @default.
• W2893018960 hasConcept C71240020 @default.
• W2893018960 hasConcept C86803240 @default.
• W2893018960 hasConceptScore W2893018960C112887158 @default.
• W2893018960 hasConceptScore W2893018960C121608353 @default.
• W2893018960 hasConceptScore W2893018960C123321153 @default.
• W2893018960 hasConceptScore W2893018960C137277065 @default.
• W2893018960 hasConceptScore W2893018960C147597530 @default.
• W2893018960 hasConceptScore W2893018960C178790620 @default.
• W2893018960 hasConceptScore W2893018960C180577832 @default.
• W2893018960 hasConceptScore W2893018960C181199279 @default.
• W2893018960 hasConceptScore W2893018960C185592680 @default.
• W2893018960 hasConceptScore W2893018960C21951064 @default.
• W2893018960 hasConceptScore W2893018960C25057246 @default.
• W2893018960 hasConceptScore W2893018960C2780456651 @default.
• W2893018960 hasConceptScore W2893018960C32909587 @default.
• W2893018960 hasConceptScore W2893018960C54355233 @default.
• W2893018960 hasConceptScore W2893018960C55493867 @default.
• W2893018960 hasConceptScore W2893018960C59593255 @default.
• W2893018960 hasConceptScore W2893018960C70721500 @default.
• W2893018960 hasConceptScore W2893018960C71240020 @default.
• W2893018960 hasConceptScore W2893018960C86803240 @default.
• W2893018960 hasFunder F4320306080 @default.
• W2893018960 hasFunder F4320321837 @default.
• W2893018960 hasFunder F4320322926 @default.
• W2893018960 hasIssue "41" @default.
• W2893018960 hasLocation W28930189601 @default.
• W2893018960 hasLocation W28930189602 @default.
• W2893018960 hasLocation W28930189603 @default.
• W2893018960 hasLocation W28930189604 @default.
• W2893018960 hasLocation W28930189605 @default.
• W2893018960 hasOpenAccess W2893018960 @default.
• W2893018960 hasPrimaryLocation W28930189601 @default.
• W2893018960 hasRelatedWork W1966769779 @default.
• W2893018960 hasRelatedWork W1973592404 @default.
• W2893018960 hasRelatedWork W1984537672 @default.

• next