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• W2893022210 abstract "Abstract Enniatins are mycotoxins of Fusarium fungi that naturally exist as mixtures of cyclic depsipeptides. Previous reports have documented hazardous effects of enniatins on cells, such as apoptosis. However, their effects on pre‐ and post‐implantation embryonic development require further clarification. Here, we showed for the first time that enniatin B1 (ENN B1) exerts cytotoxic effects on mouse blastocyst‐stage embryos and induces intracellular oxidative stress and immunotoxicity in mouse fetuses. Co‐incubation of blastocysts with ENN B1 triggered significant apoptosis and led to a decrease in total cell number predominantly through loss of inner cell mass. In addition, ENN B1 appeared to exert hazardous effects on pre and postimplantation embryo development potential in an in vitro development assay. Treatment of blastocysts with 1‐10 μM ENN B1 led to increased resorption of post‐implantation embryos and decreased fetal weight in the embryo transfer assay in a dose‐dependent manner. Importantly, in an in vivo model, intravenous injection with ENN B1 (1, 3, and 5 mg/kg body weight/d) for 4 days resulted in apoptosis of blastocyst‐stage embryos and impairment of embryonic development from the zygote to blastocyst stage, subsequent degradation of embryos, and further decrease in fetal weight. Intravenous injection with 5 mg/kg body weight/d ENN B1 additionally induced a significant increase in total reactive oxygen species (ROS) content and transcription levels of genes encoding antioxidant proteins in mouse fetal liver. Moreover, ENN B1 triggered apoptosis through ROS generation and strategies to prevent apoptotic processes effectively rescued ENN B1‐mediated hazardous effects on embryonic development. Transcription levels of CXCL1, IL‐1β, and IL‐8 related to innate immunity were downregulated after intravenous injection of ENN B1. These results collectively highlight the potential of ENN B1 to exert cytotoxic effects on embryos as well as oxidative stress and immunotoxicity during mouse embryo development." @default.
• W2893022210 created "2018-10-05" @default.
• W2893022210 creator A5022332471 @default.
• W2893022210 creator A5022839686 @default.
• W2893022210 creator A5048560198 @default.
• W2893022210 date "2018-09-26" @default.
• W2893022210 modified "2023-10-05" @default.
• W2893022210 title "Enniatin B1 exerts embryotoxic effects on mouse blastocysts and induces oxidative stress and immunotoxicity during embryo development" @default.
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• W2893022210 doi "https://doi.org/10.1002/tox.22656" @default.
• W2893022210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30259633" @default.
• W2893022210 hasPublicationYear "2018" @default.
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