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• W2893024471 abstract "The mechanisms underlying the overlap of, and relationship between, atopy and immunodeficiency are just beginning to be recognized, through the identification of novel genetic conditions and the reexamination of well known primary immunodeficiencies. The present review seeks both to frame the topic and to highlight the most recent literature combining allergy in the context of immunodeficiency.The true prevalence of atopic disorders in the setting of primary immunodeficiency as a whole is difficult to pinpoint, however there have been recent attempts to measure prevalence. Individual immunodeficiency disorders have been more carefully dissected for atopic disease and the mechanisms underlying the atopic phenotypic, whereas several newly described immune deficiencies because of single gene mutations are highly associated with atopic phenotypes. Finally, a number of novel genetic conditions with atopy being the primary feature, even in the absence of overt immune deficiency, have been described, providing instrumental clues into the diagnostic dilemmas these syndromes create.Defining and examining diseases with primary features of atopy and infection allow for a better understanding of the interplay between the two in rare disease, and hopefully sheds light on fundamental pathways involved in atopy and host defense in the general population." @default.
• W2893024471 created "2018-10-05" @default.
• W2893024471 creator A5002507553 @default.
• W2893024471 creator A5056949003 @default.
• W2893024471 date "2018-12-01" @default.
• W2893024471 modified "2023-09-27" @default.
• W2893024471 title "The overlap between allergy and immunodeficiency" @default.
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• W2893024471 doi "https://doi.org/10.1097/mop.0000000000000697" @default.
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