Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893026619> ?p ?o ?g. }
- W2893026619 endingPage "4422" @default.
- W2893026619 startingPage "4409" @default.
- W2893026619 abstract "Abstract Chlamydia psittaci is an obligate intracellular pathogen with a biphasic developmental life cycle. It is auxotrophic for a variety of essential metabolites and obtains amino acids from eukaryotic host cells. Chlamydia can develop inside host cells within chlamydial inclusions. A pathway secreting proteins from inclusions into the host cellular cytoplasm is the type III secretion system (T3SS). The T3SS is universal among several Gram‐negative bacteria. Here, we show that CPSIT_0959 of C. psittaci is expressed midcycle and secreted into the infected cellular cytoplasm via the T3SS. Recombinant CPSIT_0959 possesses cysteine desulfurase and PLP‐binding activity, which removes sulfur from cysteine to produce alanine, and helps chlamydial replication. Our study shows that CPSIT_0959 improve the infectivity of offspring elementary bodies and seems to promote the replication by its product. This phenomenon has inhibited by the PLP‐dependent enzymes inhibitor. Moreover, CPSIT_0959 increased expression of Bim and tBid, and decreased the mitochondrial membrane potential of host mitochondria to induce apoptosis in the latecycle for release of offspring. These results demonstrate that CPSIT_0959 has cysteine desulfurase and PLP‐binding activity and is likely to contribute to apoptosis of the infected cells via a mitochondria‐mediated pathway to improve the infectivity of progeny." @default.
- W2893026619 created "2018-10-05" @default.
- W2893026619 creator A5003705537 @default.
- W2893026619 creator A5009144350 @default.
- W2893026619 creator A5009331640 @default.
- W2893026619 creator A5027475930 @default.
- W2893026619 creator A5028841374 @default.
- W2893026619 creator A5039339912 @default.
- W2893026619 creator A5051964346 @default.
- W2893026619 creator A5064883666 @default.
- W2893026619 creator A5078084988 @default.
- W2893026619 creator A5086243301 @default.
- W2893026619 date "2018-09-27" @default.
- W2893026619 modified "2023-09-30" @default.
- W2893026619 title "Localization and characterization of a putative cysteine desulfurase in Chlamydia psittaci" @default.
- W2893026619 cites W1518956445 @default.
- W2893026619 cites W1963704916 @default.
- W2893026619 cites W1968589725 @default.
- W2893026619 cites W1981751768 @default.
- W2893026619 cites W1986010689 @default.
- W2893026619 cites W1993342588 @default.
- W2893026619 cites W1995687577 @default.
- W2893026619 cites W2005473844 @default.
- W2893026619 cites W2007262878 @default.
- W2893026619 cites W2007996130 @default.
- W2893026619 cites W2024152854 @default.
- W2893026619 cites W2036360313 @default.
- W2893026619 cites W2050069092 @default.
- W2893026619 cites W2055109794 @default.
- W2893026619 cites W2059110600 @default.
- W2893026619 cites W2078060963 @default.
- W2893026619 cites W2081172289 @default.
- W2893026619 cites W2084310228 @default.
- W2893026619 cites W2087921651 @default.
- W2893026619 cites W2090079874 @default.
- W2893026619 cites W2097889231 @default.
- W2893026619 cites W2099824218 @default.
- W2893026619 cites W2106004646 @default.
- W2893026619 cites W2106240937 @default.
- W2893026619 cites W2110094991 @default.
- W2893026619 cites W2116472408 @default.
- W2893026619 cites W2119656536 @default.
- W2893026619 cites W2120657426 @default.
- W2893026619 cites W2124147010 @default.
- W2893026619 cites W2127135538 @default.
- W2893026619 cites W2127318266 @default.
- W2893026619 cites W2127541870 @default.
- W2893026619 cites W2128742965 @default.
- W2893026619 cites W2144251138 @default.
- W2893026619 cites W2146681103 @default.
- W2893026619 cites W2154376092 @default.
- W2893026619 cites W2165347862 @default.
- W2893026619 cites W2165524414 @default.
- W2893026619 cites W2168974130 @default.
- W2893026619 cites W2172430381 @default.
- W2893026619 cites W2172604359 @default.
- W2893026619 cites W2320137340 @default.
- W2893026619 cites W2320355255 @default.
- W2893026619 cites W2331640295 @default.
- W2893026619 cites W2412512112 @default.
- W2893026619 cites W2417409156 @default.
- W2893026619 cites W2555909482 @default.
- W2893026619 cites W2740413175 @default.
- W2893026619 doi "https://doi.org/10.1002/jcb.27727" @default.
- W2893026619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30260037" @default.
- W2893026619 hasPublicationYear "2018" @default.
- W2893026619 type Work @default.
- W2893026619 sameAs 2893026619 @default.
- W2893026619 citedByCount "5" @default.
- W2893026619 countsByYear W28930266192019 @default.
- W2893026619 countsByYear W28930266192020 @default.
- W2893026619 countsByYear W28930266192021 @default.
- W2893026619 countsByYear W28930266192022 @default.
- W2893026619 crossrefType "journal-article" @default.
- W2893026619 hasAuthorship W2893026619A5003705537 @default.
- W2893026619 hasAuthorship W2893026619A5009144350 @default.
- W2893026619 hasAuthorship W2893026619A5009331640 @default.
- W2893026619 hasAuthorship W2893026619A5027475930 @default.
- W2893026619 hasAuthorship W2893026619A5028841374 @default.
- W2893026619 hasAuthorship W2893026619A5039339912 @default.
- W2893026619 hasAuthorship W2893026619A5051964346 @default.
- W2893026619 hasAuthorship W2893026619A5064883666 @default.
- W2893026619 hasAuthorship W2893026619A5078084988 @default.
- W2893026619 hasAuthorship W2893026619A5086243301 @default.
- W2893026619 hasConcept C181199279 @default.
- W2893026619 hasConcept C190062978 @default.
- W2893026619 hasConcept C2777667758 @default.
- W2893026619 hasConcept C2779201268 @default.
- W2893026619 hasConcept C2780122209 @default.
- W2893026619 hasConcept C54355233 @default.
- W2893026619 hasConcept C55493867 @default.
- W2893026619 hasConcept C86803240 @default.
- W2893026619 hasConcept C95444343 @default.
- W2893026619 hasConceptScore W2893026619C181199279 @default.
- W2893026619 hasConceptScore W2893026619C190062978 @default.
- W2893026619 hasConceptScore W2893026619C2777667758 @default.
- W2893026619 hasConceptScore W2893026619C2779201268 @default.
- W2893026619 hasConceptScore W2893026619C2780122209 @default.