Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893034970> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2893034970 endingPage "110" @default.
- W2893034970 startingPage "91" @default.
- W2893034970 abstract "A psychobiological model of the etiopathology of bipolar disorder is proposed. Based on genetic-epigenetic and chronobiological factors a hyperintentional personality structure, if faced with non-feasible intentional programs in the environment, suffers from inner and outer stress. This stress situation leads to imbalances in information processing in glial-neuronal synaptic units, called tripartite synapses. In depression the overexpression of astrocytic receptors and of gap junctions in the astroglial network causes a prolonged information processing which affects the behavior generating systems in the brainstem reticular formation. Because the activation of the behavior generating systems is protracted, they are unable to select an appropriate mode of behavior (e.g. communicating, eating, working, sleeping, etc.) from sensory information in real time. Inversely, in mania astrocytic receptors and gap junctions are underexpressed causing a shortened synaptic information processing with rapid changes in behavior. Switching may represent a coping-attempt with depression by mania and vice versa. Towards a comprehensive model of the pathophysiology of bipolar disorder the role of microglia and their devastating effects on glial-neuronal interactions are outlined. Finally, the testing of the model is discussed." @default.
- W2893034970 created "2018-10-05" @default.
- W2893034970 creator A5089726891 @default.
- W2893034970 date "2018-01-01" @default.
- W2893034970 modified "2023-09-26" @default.
- W2893034970 title "Psychobiological Model of Bipolar Disorder: Based on Imbalances of Glial-Neuronal Information Processing" @default.
- W2893034970 cites W1490260659 @default.
- W2893034970 cites W1544297865 @default.
- W2893034970 cites W1569986489 @default.
- W2893034970 cites W1572404682 @default.
- W2893034970 cites W1930790356 @default.
- W2893034970 cites W1939097681 @default.
- W2893034970 cites W1968718808 @default.
- W2893034970 cites W1981559654 @default.
- W2893034970 cites W1997245512 @default.
- W2893034970 cites W2004209700 @default.
- W2893034970 cites W2012096066 @default.
- W2893034970 cites W2020544926 @default.
- W2893034970 cites W2020654785 @default.
- W2893034970 cites W2022480454 @default.
- W2893034970 cites W2023311108 @default.
- W2893034970 cites W2028131345 @default.
- W2893034970 cites W2036131929 @default.
- W2893034970 cites W2039839952 @default.
- W2893034970 cites W2044730840 @default.
- W2893034970 cites W2058448129 @default.
- W2893034970 cites W2064931619 @default.
- W2893034970 cites W2072191054 @default.
- W2893034970 cites W2074552681 @default.
- W2893034970 cites W2089216562 @default.
- W2893034970 cites W2089430357 @default.
- W2893034970 cites W2096244217 @default.
- W2893034970 cites W2123633938 @default.
- W2893034970 cites W2130276206 @default.
- W2893034970 cites W2138730565 @default.
- W2893034970 cites W2159011576 @default.
- W2893034970 cites W2165096765 @default.
- W2893034970 cites W2167193785 @default.
- W2893034970 cites W2205226619 @default.
- W2893034970 cites W2292932763 @default.
- W2893034970 cites W2494256336 @default.
- W2893034970 cites W2552408318 @default.
- W2893034970 cites W2553608151 @default.
- W2893034970 cites W2586261884 @default.
- W2893034970 cites W3084203601 @default.
- W2893034970 cites W3213779415 @default.
- W2893034970 cites W49566797 @default.
- W2893034970 cites W972583108 @default.
- W2893034970 cites W2787723705 @default.
- W2893034970 doi "https://doi.org/10.4236/ojmp.2018.74008" @default.
- W2893034970 hasPublicationYear "2018" @default.
- W2893034970 type Work @default.
- W2893034970 sameAs 2893034970 @default.
- W2893034970 citedByCount "2" @default.
- W2893034970 countsByYear W28930349702020 @default.
- W2893034970 crossrefType "journal-article" @default.
- W2893034970 hasAuthorship W2893034970A5089726891 @default.
- W2893034970 hasBestOaLocation W28930349701 @default.
- W2893034970 hasConcept C15744967 @default.
- W2893034970 hasConcept C169760540 @default.
- W2893034970 hasConcept C169900460 @default.
- W2893034970 hasConcept C2776174506 @default.
- W2893034970 hasConcept C2776809841 @default.
- W2893034970 hasConcept C551621295 @default.
- W2893034970 hasConcept C87868495 @default.
- W2893034970 hasConceptScore W2893034970C15744967 @default.
- W2893034970 hasConceptScore W2893034970C169760540 @default.
- W2893034970 hasConceptScore W2893034970C169900460 @default.
- W2893034970 hasConceptScore W2893034970C2776174506 @default.
- W2893034970 hasConceptScore W2893034970C2776809841 @default.
- W2893034970 hasConceptScore W2893034970C551621295 @default.
- W2893034970 hasConceptScore W2893034970C87868495 @default.
- W2893034970 hasIssue "04" @default.
- W2893034970 hasLocation W28930349701 @default.
- W2893034970 hasOpenAccess W2893034970 @default.
- W2893034970 hasPrimaryLocation W28930349701 @default.
- W2893034970 hasRelatedWork W193023290 @default.
- W2893034970 hasRelatedWork W2016374075 @default.
- W2893034970 hasRelatedWork W2090133160 @default.
- W2893034970 hasRelatedWork W2102123970 @default.
- W2893034970 hasRelatedWork W2132014094 @default.
- W2893034970 hasRelatedWork W2148770702 @default.
- W2893034970 hasRelatedWork W2390951968 @default.
- W2893034970 hasRelatedWork W2462983098 @default.
- W2893034970 hasRelatedWork W3176398639 @default.
- W2893034970 hasRelatedWork W3198313168 @default.
- W2893034970 hasVolume "07" @default.
- W2893034970 isParatext "false" @default.
- W2893034970 isRetracted "false" @default.
- W2893034970 magId "2893034970" @default.
- W2893034970 workType "article" @default.