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- W2893037184 abstract "Background Fatigue is a common phenomenon in primary Sjogren’s syndrome (pSS) and other chronic inflammatory diseases, cancer, and neurodegeneration. The underlying mechanisms for fatigue are not completely understood, but increasing evidence point to a biological basis for the phenomenon. Objectives Following the sickness behaviour hypothesis for fatigue, where pro-inflammatory cytokines and particularly interleukin 1β (IL-1β) related signalling are essential, we wished to investigate how molecules that influence IL-1β activity may influence fatigue through complex networks (IL-1β, IL-1Ra, IL-1RII, IL-6 and S100B). We also hypothesised that the neuropeptide hypocretin-1 (Hcrt1), a regulator of sleep and wakefulness, could be an element in a network for fatigue. Methods In cerebrospinal fluid (CSF) from 49 patients with pSS, Hcrt1 was measured by RIA and the other proteins by ELISA. Fatigue was rated using the fatigue visual analogue scale (fVAS), and results analysed by univariate-, multiple regression, and principal component analysis (PCA). Results It was not possible to measure IL-1b due to very low concentrations in CSF. In simple univariate regression analysis with fatigue as a dependent variable a significant association was observed for depression (R2=0.20, p Conclusions The main findings in this study indicate a functional network in which several IL-1β related molecules in CSF influence fatigue in addition to the clinical factors depression and pain. The neuropeptide Hcrt1 seem to participate in fatigue signalling, but probably not through the IL-1 pathway. Disclosure of Interest None declared" @default.
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- W2893037184 date "2018-06-01" @default.
- W2893037184 modified "2023-10-17" @default.
- W2893037184 title "FRI0280 A molecular network for fatigue in primary sjÖgren’s syndrome" @default.
- W2893037184 doi "https://doi.org/10.1136/annrheumdis-2018-eular.3656" @default.
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