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• W2893045005 abstract "Three binuclear platinum(II) complexes, 1 ([Pt2(L)Cl2]Cl2), 2 ([Pt2(L)Br2]Br2) and 3 ([Pt2(L)I2]I2) (where L = 1,4-bi-[4′-(4-Hydroxyphenyl)-2,2′,6′,2″-terpyridine] butane) were synthesized and characterized by nuclear magnetic resonance, elemental analysis and mass spectrometry. The crystal structure of the new ligand L was determined by single crystal X-ray crystallography, and π–π stacking interactions were revealed in the geometry. Interactions of complexes with calf thymus DNA have been investigated by UV–Vis spectroscopy and fluorescence spectroscopy. Due to the structural differences, binuclear complex 3 exhibited higher binding affinity for calf thymus DNA with a DNA-binding constant Kb of 8.72 × 106 M−1. The competitive study indicated that the ethidium bromide (EB) can displaced by complexes 1–3 from the DNA-EB conjugation. The concentration-dependence unwinding of supercoiled circular plasmid pBR322 DNA by complexes 1–3 was observed via agarose gel electrophoresis. Meanwhile, complexes displayed obvious activities for inhibition of topoisomerase I. Herein the halogen leaving groups Cl−/Br−/I− presented in 1–3 showed significant effect on DNA binding and topoisomerase I inhibition activities. An evaluation of in vitro cytotoxicity for three complexes was performed by MTT assay in two cancer cell lines and normal cells as the control, respectively." @default.
• W2893045005 created "2018-10-05" @default.
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• W2893045005 date "2019-01-01" @default.
• W2893045005 modified "2023-10-16" @default.
• W2893045005 title "Synthesis, DNA binding, topoisomerase I inhibition and antiproliferation activities of three new binuclear terpyridine platinum(II) complexes" @default.
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• W2893045005 doi "https://doi.org/10.1016/j.poly.2018.09.053" @default.
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