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- W2893051636 abstract "Voltage gated calcium channels (VGCC) are well-known targets for antibody-associated disease. Of the 5 VGCC subtypes, the most well-known is the P/Q subtype associated with Lambert-Eaton Myasthenic Syndrome (LEMS). However, this case focuses on the much less understood N-type calcium channel antibody. The objective of this case is to review the literature regarding the clinical significance of the N-type calcium channel antibody and its relationship to MS.A 37-year old male presented with vertigo, paranoia, and tremor and had MRI changes suggestive of demyelinating disease. Evaluation revealed positive N-type calcium channel antibodies. Steroids dramatically improved symptoms and normalized antibodies. Years later recurrent symptoms were again associated with elevated antibodies.This patient likely has autoimmune encephalitis associated with elevated N-type calcium channel antibodies. This case highlights the clinical significance of N-type calcium channel antibodies and the importance of correctly diagnosing patients with antibody mediated disease that may very well mimic more common neurologic diseases such as multiple sclerosis (MS)." @default.
- W2893051636 created "2018-10-05" @default.
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- W2893051636 date "2018-11-01" @default.
- W2893051636 modified "2023-10-16" @default.
- W2893051636 title "Autoimmune encephalitis with elevated N-type calcium channel antibodies as a multiple sclerosis mimic" @default.
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- W2893051636 doi "https://doi.org/10.1016/j.msard.2018.09.028" @default.
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