Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893056942> ?p ?o ?g. }
- W2893056942 endingPage "331" @default.
- W2893056942 startingPage "321" @default.
- W2893056942 abstract "microRNA-139 (miR-139) is dysregulated in various types of tumors and plays a key role in carcinogenesis. miR-139 may be used as a diagnostic and prognostic biomarker of cancers. However, the data from the literature are not consistent. The present study aimed to verify the prognostic and diagnostic values of miR-139 in solid tumors. PubMed, Web of Science and Embase databases were searched and publications from January 2011 to August 2017 were included. We used Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) database to further validate this meta-analysis. Eight individual studies from seven articles were included. Pooled analyses showed that low miR-139 expression was related to worse overall survival (OS) [hazard ratio (HR) = 2.27; 95% confidence intervals (CI): 1.74–2.95; P < 0.001] in solid tumors, including hepatocellular carcinoma (HCC) and glioblastoma multiforme (GBM), consisting with the results of TCGA. However, our results of CRC showed that low miR-139 expression was associated with poor OS which was contradictory with the results in TCGA database and need larger samples to validate the phenomenon; whereas for CRC patients, high miR-139 expression predicted poor RFS, which was in good accordance with TCGA results. The results of 27 microarrays from GEO database showed that miR-139 expression levels were lower in tumor tissues compared to adjacent non-tumor tissues or healthy tissues. Decreased miR-139 expression was also significantly correlated with poor differentiation grade (OR = 3.57; 95% CI: 1.44–8.85; P = 0.006). However, the combined data indicated that no associations between miR-139 expression and the following parameters such as age (pooled OR = 1.50; 95% CI: 0.69–3.24; P = 0.304), gender (pooled OR = 0.92; 95% CI: 0.56–1.51; P = 0.738), tumor size (pooled OR = 1.51; 95% CI: 0.69–3.31; P = 0.298), late tumor-node-metastasis stage (pooled OR = 1.63; 95% CI: 0.99–2.68; P = 0.057) and lymph-node-metastasis (pooled OR = 0.66; 95% CI: 0.34–1.28; P = 0.222). Low miR-139 expression was related to poor prognosis in HCC and GBM, which could be regarded as a potential prognostic biomarker. However, its precise functional role in CRC still need to be further investigated through larger samples and multicenter studies." @default.
- W2893056942 created "2018-10-05" @default.
- W2893056942 creator A5003281764 @default.
- W2893056942 creator A5017119373 @default.
- W2893056942 creator A5030303113 @default.
- W2893056942 creator A5033031458 @default.
- W2893056942 creator A5053415959 @default.
- W2893056942 creator A5055452069 @default.
- W2893056942 creator A5064711465 @default.
- W2893056942 creator A5072422907 @default.
- W2893056942 creator A5085570062 @default.
- W2893056942 date "2019-08-01" @default.
- W2893056942 modified "2023-10-16" @default.
- W2893056942 title "Low microRNA-139 expression associates with poor prognosis in patients with tumors: A meta-analysis" @default.
- W2893056942 cites W1613375507 @default.
- W2893056942 cites W1648301895 @default.
- W2893056942 cites W1964435302 @default.
- W2893056942 cites W1968011243 @default.
- W2893056942 cites W1989071751 @default.
- W2893056942 cites W2001476170 @default.
- W2893056942 cites W2006247279 @default.
- W2893056942 cites W2032630075 @default.
- W2893056942 cites W2035310028 @default.
- W2893056942 cites W2036801235 @default.
- W2893056942 cites W2050079849 @default.
- W2893056942 cites W2078719023 @default.
- W2893056942 cites W2087990232 @default.
- W2893056942 cites W2088833308 @default.
- W2893056942 cites W2107328434 @default.
- W2893056942 cites W2117951804 @default.
- W2893056942 cites W2133650808 @default.
- W2893056942 cites W2136362813 @default.
- W2893056942 cites W2148287035 @default.
- W2893056942 cites W2152580674 @default.
- W2893056942 cites W2157823046 @default.
- W2893056942 cites W2235523043 @default.
- W2893056942 cites W2261422334 @default.
- W2893056942 cites W2272984102 @default.
- W2893056942 cites W2286680901 @default.
- W2893056942 cites W2521020983 @default.
- W2893056942 cites W2593902227 @default.
- W2893056942 cites W2743527978 @default.
- W2893056942 cites W2917837889 @default.
- W2893056942 cites W4237011200 @default.
- W2893056942 doi "https://doi.org/10.1016/j.hbpd.2018.09.016" @default.
- W2893056942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30290990" @default.
- W2893056942 hasPublicationYear "2019" @default.
- W2893056942 type Work @default.
- W2893056942 sameAs 2893056942 @default.
- W2893056942 citedByCount "14" @default.
- W2893056942 countsByYear W28930569422019 @default.
- W2893056942 countsByYear W28930569422020 @default.
- W2893056942 countsByYear W28930569422021 @default.
- W2893056942 countsByYear W28930569422022 @default.
- W2893056942 countsByYear W28930569422023 @default.
- W2893056942 crossrefType "journal-article" @default.
- W2893056942 hasAuthorship W2893056942A5003281764 @default.
- W2893056942 hasAuthorship W2893056942A5017119373 @default.
- W2893056942 hasAuthorship W2893056942A5030303113 @default.
- W2893056942 hasAuthorship W2893056942A5033031458 @default.
- W2893056942 hasAuthorship W2893056942A5053415959 @default.
- W2893056942 hasAuthorship W2893056942A5055452069 @default.
- W2893056942 hasAuthorship W2893056942A5064711465 @default.
- W2893056942 hasAuthorship W2893056942A5072422907 @default.
- W2893056942 hasAuthorship W2893056942A5085570062 @default.
- W2893056942 hasConcept C104317684 @default.
- W2893056942 hasConcept C121608353 @default.
- W2893056942 hasConcept C126322002 @default.
- W2893056942 hasConcept C143998085 @default.
- W2893056942 hasConcept C145059251 @default.
- W2893056942 hasConcept C207103383 @default.
- W2893056942 hasConcept C2778019345 @default.
- W2893056942 hasConcept C2781197716 @default.
- W2893056942 hasConcept C41008148 @default.
- W2893056942 hasConcept C44249647 @default.
- W2893056942 hasConcept C55493867 @default.
- W2893056942 hasConcept C555283112 @default.
- W2893056942 hasConcept C60644358 @default.
- W2893056942 hasConcept C71924100 @default.
- W2893056942 hasConcept C77088390 @default.
- W2893056942 hasConcept C86803240 @default.
- W2893056942 hasConcept C95190672 @default.
- W2893056942 hasConceptScore W2893056942C104317684 @default.
- W2893056942 hasConceptScore W2893056942C121608353 @default.
- W2893056942 hasConceptScore W2893056942C126322002 @default.
- W2893056942 hasConceptScore W2893056942C143998085 @default.
- W2893056942 hasConceptScore W2893056942C145059251 @default.
- W2893056942 hasConceptScore W2893056942C207103383 @default.
- W2893056942 hasConceptScore W2893056942C2778019345 @default.
- W2893056942 hasConceptScore W2893056942C2781197716 @default.
- W2893056942 hasConceptScore W2893056942C41008148 @default.
- W2893056942 hasConceptScore W2893056942C44249647 @default.
- W2893056942 hasConceptScore W2893056942C55493867 @default.
- W2893056942 hasConceptScore W2893056942C555283112 @default.
- W2893056942 hasConceptScore W2893056942C60644358 @default.
- W2893056942 hasConceptScore W2893056942C71924100 @default.
- W2893056942 hasConceptScore W2893056942C77088390 @default.
- W2893056942 hasConceptScore W2893056942C86803240 @default.