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- W2893057585 abstract "The aim of this study was to evaluate the effectiveness of a pilocarpine spray as a treatment for xerostomia in patients treated with radiotherapy (RT) for head and neck cancer (HNC) through a prospective, randomized, double-blind, crossover, placebo-controlled clinical trial. Twenty-eight patients were treated with pilocarpine spray or with placebo for 3 months, with a 1-month washout period between treatments. Outcome measures were salivary flow (Stimulated Sialometry [SS]), xerostomia (Xerostomia Inventory [XI]), and quality of life (QoL; Oral Health Impact Profile [OHIP-14]), which were evaluated at baseline and at 1, 2, and 3 months of treatment. The pilocarpine spray significantly increased the SS after 1 hour (P = .003) and 2 months (P = .002) of using the spray and improved xerostomia symptoms (P < .05) and QoL (P < .05). Topical application of pilocarpine spray is an effective therapeutic option for managing xerostomia in patients treated with RT for HNC." @default.
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- W2893057585 date "2018-09-01" @default.
- W2893057585 modified "2023-09-27" @default.
- W2893057585 title "Pilocarpine Spray for the Treatment of Xerostomia: a Randomized, Double-Blind, Placebo-Controlled Trial" @default.
- W2893057585 doi "https://doi.org/10.1016/j.oooo.2018.02.057" @default.
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