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- W2893058498 abstract "Introduction: The early postnatal mouse heart is still growing by proliferation and differentiation of cardiomyocytes (CMC) to just after the first week of life. Vascular growth in this time period is also crucial as the left ventricular myocardium must prepare for a near doubling of work load at birth, which includes having an adequate vascular tree to supply the muscle itself. CMC-specific loss of B-Raf leads to lesser CMC volume fraction, at 3 and 8 days postnatal reflective of blunted CMC proliferation. Hypothesis: We hypothesize CMC-specific loss of B-Raf reduces vascular growth signals. Methods: CMC-specific knockout (KO) of B-Raf was generated using CRE/lox (floxed B-Raf x αMHC CRE) resulting in a truncated, unstable B-Raf and a null phenotype. KO mice (α-MHC-CRE / B-Raf lox/lox) were compared to CRE negative / B-Raf lox/lox mice (wild type; WT). Hearts from postnatal day (PND) 1, 3, 8, and 14 pups were harvested for molecular analysis (n=8/age group). Expression levels of vascular factors were det..." @default.
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- W2893058498 date "2016-11-11" @default.
- W2893058498 modified "2023-09-24" @default.
- W2893058498 title "Abstract 20783: B-Raf Regulates Vascular Growth Signaling in the Neonatal Mouse Heart" @default.
- W2893058498 hasPublicationYear "2016" @default.
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