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- W2893059110 abstract "Autophagy, a highly conserved process, serves to maintain cellular homeostasis in response to an extensive variety of internal and external stimuli. The classic, or canonical, pathway of autophagy involves the coordinated degradation and recycling of intracellular components and pathogenic material. Proper regulation of autophagy is critical to maintain cellular health, as alterations in the autophagy pathway have been linked to the progression of a variety of physiological and pathological conditions in humans, namely in aging and in viral infection. In addition to its canonical role as a degradative pathway, a more unconventional and non-degradative role for autophagy has emerged as an area of increasing interest. This process, known as secretory autophagy, is gaining widespread attention as many viruses are believed to use this pathway as a means to release and spread viral particles. Moreover, secretory autophagy has been found to intersect with other intracellular pathways, such as the biogenesis and secretion of extracellular vesicles (EVs). Here, we provide a review of the current landscape surrounding both degradative autophagy and secretory autophagy in relation to both aging and viral infection. We discuss their key features, while describing their interplay with numerous different viruses (i.e. hepatitis B and C viruses, Epstein-Barr virus, SV40, herpesviruses, HIV, chikungunya virus, dengue virus, Zika virus, Ebola virus, HTLV, Rift Valley fever virus, poliovirus, and influenza A virus), and compare secretory autophagy to other pathways of extracellular vesicle release. Lastly, we highlight the need for, and emphasize the importance of, more thorough methods to study the underlying mechanisms of these pathways to better advance our understanding of disease progression." @default.
- W2893059110 created "2018-10-05" @default.
- W2893059110 creator A5000297941 @default.
- W2893059110 creator A5005450720 @default.
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- W2893059110 creator A5024276308 @default.
- W2893059110 creator A5048070062 @default.
- W2893059110 creator A5063715894 @default.
- W2893059110 creator A5091751961 @default.
- W2893059110 date "2018-10-18" @default.
- W2893059110 modified "2023-10-18" @default.
- W2893059110 title "Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time" @default.
- W2893059110 cites W1170418387 @default.
- W2893059110 cites W1205458192 @default.
- W2893059110 cites W1523693806 @default.
- W2893059110 cites W1526993239 @default.
- W2893059110 cites W1535490554 @default.
- W2893059110 cites W1606372320 @default.
- W2893059110 cites W1624269400 @default.
- W2893059110 cites W1757008411 @default.
- W2893059110 cites W1845094941 @default.
- W2893059110 cites W1877686344 @default.
- W2893059110 cites W1913259696 @default.
- W2893059110 cites W1963547612 @default.
- W2893059110 cites W1963973972 @default.
- W2893059110 cites W1965106474 @default.
- W2893059110 cites W1965205152 @default.
- W2893059110 cites W1965603799 @default.
- W2893059110 cites W1967809393 @default.
- W2893059110 cites W1969607893 @default.
- W2893059110 cites W1970637701 @default.
- W2893059110 cites W1971204908 @default.
- W2893059110 cites W1974368123 @default.
- W2893059110 cites W1975924645 @default.
- W2893059110 cites W1976196055 @default.
- W2893059110 cites W1976896833 @default.
- W2893059110 cites W1979661536 @default.
- W2893059110 cites W1981888655 @default.
- W2893059110 cites W1986536654 @default.
- W2893059110 cites W1987769185 @default.
- W2893059110 cites W1989637234 @default.
- W2893059110 cites W1990293380 @default.
- W2893059110 cites W1990437594 @default.
- W2893059110 cites W1991259997 @default.
- W2893059110 cites W1992257057 @default.
- W2893059110 cites W1992523266 @default.
- W2893059110 cites W1993690543 @default.
- W2893059110 cites W1994423882 @default.
- W2893059110 cites W1994527574 @default.
- W2893059110 cites W1994823455 @default.
- W2893059110 cites W1997913020 @default.
- W2893059110 cites W1998794502 @default.
- W2893059110 cites W1999767183 @default.
- W2893059110 cites W2001467419 @default.
- W2893059110 cites W2001568034 @default.
- W2893059110 cites W2001790634 @default.
- W2893059110 cites W2001823167 @default.
- W2893059110 cites W2002446310 @default.
- W2893059110 cites W2006840724 @default.
- W2893059110 cites W2009409181 @default.
- W2893059110 cites W2010050523 @default.
- W2893059110 cites W2011580247 @default.
- W2893059110 cites W2012784876 @default.
- W2893059110 cites W2014140858 @default.
- W2893059110 cites W2021335029 @default.
- W2893059110 cites W2022964430 @default.
- W2893059110 cites W2023797541 @default.
- W2893059110 cites W2024578713 @default.
- W2893059110 cites W2025872915 @default.
- W2893059110 cites W2026044755 @default.
- W2893059110 cites W2026876894 @default.
- W2893059110 cites W2027195751 @default.
- W2893059110 cites W2027446523 @default.
- W2893059110 cites W2027558005 @default.
- W2893059110 cites W2031277784 @default.
- W2893059110 cites W2031754652 @default.
- W2893059110 cites W2032700869 @default.
- W2893059110 cites W2033295839 @default.
- W2893059110 cites W2034087770 @default.
- W2893059110 cites W2035861820 @default.
- W2893059110 cites W2036229829 @default.
- W2893059110 cites W2036701722 @default.
- W2893059110 cites W2037653131 @default.
- W2893059110 cites W2038363115 @default.
- W2893059110 cites W2042433863 @default.
- W2893059110 cites W2047563058 @default.
- W2893059110 cites W2047690887 @default.
- W2893059110 cites W2048030072 @default.
- W2893059110 cites W2049016912 @default.
- W2893059110 cites W2050541584 @default.
- W2893059110 cites W2052282580 @default.
- W2893059110 cites W2053581512 @default.
- W2893059110 cites W2055346100 @default.
- W2893059110 cites W2055654995 @default.
- W2893059110 cites W2061091970 @default.
- W2893059110 cites W2061308761 @default.
- W2893059110 cites W2062819360 @default.
- W2893059110 cites W2063323349 @default.
- W2893059110 cites W2065031087 @default.