FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893059853> ?p ?o ?g. }

• W2893059853 endingPage "323" @default.
• W2893059853 startingPage "314" @default.
• W2893059853 abstract "Abstract Aging is associated with a decline of performance leading to reduced reproductive output and survival. While the antagonistic pleiotropy theory of aging has attracted considerable attention, the molecular/physiological functions underlying the early‐life benefits/late‐life costs paradigm remain elusive. We tested the hypothesis that while early activation of the inflammatory response confers benefits in terms of protection against infection, it also incurs costs in terms of reduced reproductive output at old age and shortened longevity. We infected mice with the malaria parasite Plasmodium yoelii and increased the inflammatory response using an anti‐IL‐10 receptor antibody treatment. We quantified the benefits and costs of the inflammatory response during the acute phase of the infection and at old age. In agreement with the antagonistic pleiotropy hypothesis, the inflammatory response provided an early‐life benefit, since infected mice that were treated with anti‐IL‐10 receptor antibodies had reduced parasite density and anemia. However, at old age, mice in all treatment groups had similar levels of C‐reactive protein, reproductive output, survival rate, and lifespan. Overall, our results do not support the hypothesis that the benefits of a robust response to malaria infection in early life incur longer term fitness costs." @default.
• W2893059853 created "2018-10-05" @default.
• W2893059853 creator A5028182769 @default.
• W2893059853 creator A5033158998 @default.
• W2893059853 creator A5037349041 @default.
• W2893059853 creator A5040526190 @default.
• W2893059853 creator A5067267094 @default.
• W2893059853 creator A5079182954 @default.
• W2893059853 creator A5085627828 @default.
• W2893059853 date "2018-10-17" @default.
• W2893059853 modified "2023-10-15" @default.
• W2893059853 title "Early <i>Plasmodium</i> -induced inflammation does not accelerate aging in mice" @default.
• W2893059853 cites W1566992315 @default.
• W2893059853 cites W1658682427 @default.
• W2893059853 cites W1966634500 @default.
• W2893059853 cites W1973042689 @default.
• W2893059853 cites W1985023036 @default.
• W2893059853 cites W1993091967 @default.
• W2893059853 cites W2000493251 @default.
• W2893059853 cites W2023095530 @default.
• W2893059853 cites W2024328614 @default.
• W2893059853 cites W2025018588 @default.
• W2893059853 cites W2027592058 @default.
• W2893059853 cites W2031084334 @default.
• W2893059853 cites W2035027338 @default.
• W2893059853 cites W2035492084 @default.
• W2893059853 cites W2035829354 @default.
• W2893059853 cites W2056709367 @default.
• W2893059853 cites W2058425124 @default.
• W2893059853 cites W2062519020 @default.
• W2893059853 cites W2070229371 @default.
• W2893059853 cites W2085193856 @default.
• W2893059853 cites W2089479018 @default.
• W2893059853 cites W2091273397 @default.
• W2893059853 cites W2093588915 @default.
• W2893059853 cites W2094431130 @default.
• W2893059853 cites W2095283592 @default.
• W2893059853 cites W2103857429 @default.
• W2893059853 cites W2105150055 @default.
• W2893059853 cites W2109288121 @default.
• W2893059853 cites W2109866208 @default.
• W2893059853 cites W2115035141 @default.
• W2893059853 cites W2124346917 @default.
• W2893059853 cites W2153366331 @default.
• W2893059853 cites W2161742531 @default.
• W2893059853 cites W2164927072 @default.
• W2893059853 cites W2165578318 @default.
• W2893059853 cites W2491739347 @default.
• W2893059853 cites W2518536270 @default.
• W2893059853 cites W2594626140 @default.
• W2893059853 cites W2746711314 @default.
• W2893059853 cites W2766095122 @default.
• W2893059853 cites W2893059853 @default.
• W2893059853 doi "https://doi.org/10.1111/eva.12718" @default.
• W2893059853 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6346666" @default.
• W2893059853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30697342" @default.
• W2893059853 hasPublicationYear "2018" @default.
• W2893059853 type Work @default.
• W2893059853 sameAs 2893059853 @default.
• W2893059853 citedByCount "4" @default.
• W2893059853 countsByYear W28930598532019 @default.
• W2893059853 countsByYear W28930598532020 @default.
• W2893059853 countsByYear W28930598532022 @default.
• W2893059853 crossrefType "journal-article" @default.
• W2893059853 hasAuthorship W2893059853A5028182769 @default.
• W2893059853 hasAuthorship W2893059853A5033158998 @default.
• W2893059853 hasAuthorship W2893059853A5037349041 @default.
• W2893059853 hasAuthorship W2893059853A5040526190 @default.
• W2893059853 hasAuthorship W2893059853A5067267094 @default.
• W2893059853 hasAuthorship W2893059853A5079182954 @default.
• W2893059853 hasAuthorship W2893059853A5085627828 @default.
• W2893059853 hasBestOaLocation W28930598531 @default.
• W2893059853 hasConcept C104317684 @default.
• W2893059853 hasConcept C127716648 @default.
• W2893059853 hasConcept C203014093 @default.
• W2893059853 hasConcept C26207810 @default.
• W2893059853 hasConcept C2775867548 @default.
• W2893059853 hasConcept C2776486806 @default.
• W2893059853 hasConcept C2776759703 @default.
• W2893059853 hasConcept C2776914184 @default.
• W2893059853 hasConcept C2778048844 @default.
• W2893059853 hasConcept C2778371730 @default.
• W2893059853 hasConcept C2779056147 @default.
• W2893059853 hasConcept C54355233 @default.
• W2893059853 hasConcept C86803240 @default.
• W2893059853 hasConcept C8891405 @default.
• W2893059853 hasConceptScore W2893059853C104317684 @default.
• W2893059853 hasConceptScore W2893059853C127716648 @default.
• W2893059853 hasConceptScore W2893059853C203014093 @default.
• W2893059853 hasConceptScore W2893059853C26207810 @default.
• W2893059853 hasConceptScore W2893059853C2775867548 @default.
• W2893059853 hasConceptScore W2893059853C2776486806 @default.
• W2893059853 hasConceptScore W2893059853C2776759703 @default.
• W2893059853 hasConceptScore W2893059853C2776914184 @default.
• W2893059853 hasConceptScore W2893059853C2778048844 @default.
• W2893059853 hasConceptScore W2893059853C2778371730 @default.
• W2893059853 hasConceptScore W2893059853C2779056147 @default.
• W2893059853 hasConceptScore W2893059853C54355233 @default.

• next