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• W2893064906 abstract "High-throughput proteomics was used to determine the role of the fish liver in defense responses to bacterial infection. This was done using a rainbow trout (Oncorhynchus mykiss) model following infection with Aeromonas salmonicida, the causative agent of furunculosis. The vertebrate liver has multifaceted functions in innate immunity, metabolism, and growth; we hypothesize this tissue serves a dual role in supporting host defense in parallel to metabolic adjustments that promote effective immune function. While past studies have reported mRNA responses to A. salmonicida in salmonids, the impact of bacterial infection on the liver proteome remains uncharacterized in fish.Rainbow trout were injected with A. salmonicida or PBS (control) and liver extracted 48 h later for analysis on a hybrid quadrupole-Orbitrap mass spectrometer. A label-free method was used for protein abundance profiling, which revealed a strong innate immune response along with evidence to support parallel rewiring of metabolic and growth systems. 3076 proteins were initially identified against all proteins (n = 71,293 RefSeq proteins) annotated in a single high-quality rainbow trout reference genome, of which 2433 were maintained for analysis post-quality filtering. Among the 2433 proteins, 109 showed significant differential abundance following A. salmonicida challenge, including many upregulated complement system and acute phase response proteins, in addition to molecules with putative functions that may support metabolic re-adjustments. We also identified novel expansions in the complement system due to gene and whole genome duplication events in salmonid evolutionary history, including eight C3 proteins showing differential changes in abundance.This study provides the first high-throughput proteomic examination of the fish liver in response to bacterial challenge, revealing novel markers for the host defense response, and evidence of metabolic remodeling in conjunction with activation of innate immunity." @default.
• W2893064906 created "2018-10-05" @default.
• W2893064906 creator A5035355955 @default.
• W2893064906 creator A5037426525 @default.
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• W2893064906 creator A5042122496 @default.
• W2893064906 creator A5069674349 @default.
• W2893064906 creator A5070305320 @default.
• W2893064906 date "2018-10-01" @default.
• W2893064906 modified "2023-10-16" @default.
• W2893064906 title "High-throughput proteomic profiling of the fish liver following bacterial infection" @default.
• W2893064906 cites W1495965894 @default.
• W2893064906 cites W1499593166 @default.
• W2893064906 cites W1512072195 @default.
• W2893064906 cites W1516862669 @default.
• W2893064906 cites W1519405541 @default.
• W2893064906 cites W1562354149 @default.
• W2893064906 cites W1597030361 @default.
• W2893064906 cites W1902509113 @default.
• W2893064906 cites W1920171370 @default.
• W2893064906 cites W1923256605 @default.
• W2893064906 cites W1964447469 @default.
• W2893064906 cites W1965512189 @default.
• W2893064906 cites W1969296748 @default.
• W2893064906 cites W1970666556 @default.
• W2893064906 cites W1975868055 @default.
• W2893064906 cites W1977358487 @default.
• W2893064906 cites W1978079881 @default.
• W2893064906 cites W1978378281 @default.
• W2893064906 cites W1982486689 @default.
• W2893064906 cites W1982856121 @default.
• W2893064906 cites W1984503539 @default.
• W2893064906 cites W1987201769 @default.
• W2893064906 cites W1989608676 @default.
• W2893064906 cites W1993248100 @default.
• W2893064906 cites W1995552322 @default.
• W2893064906 cites W1997966962 @default.
• W2893064906 cites W2000965673 @default.
• W2893064906 cites W2001145742 @default.
• W2893064906 cites W2002019043 @default.
• W2893064906 cites W2002706411 @default.
• W2893064906 cites W2002725367 @default.
• W2893064906 cites W2005076200 @default.
• W2893064906 cites W2014102887 @default.
• W2893064906 cites W2017561005 @default.
• W2893064906 cites W2021487333 @default.
• W2893064906 cites W2027077104 @default.
• W2893064906 cites W2030253887 @default.
• W2893064906 cites W2030313939 @default.
• W2893064906 cites W2032429886 @default.
• W2893064906 cites W2035323516 @default.
• W2893064906 cites W2038826912 @default.
• W2893064906 cites W2039495394 @default.
• W2893064906 cites W2041016331 @default.
• W2893064906 cites W2043841732 @default.
• W2893064906 cites W2045830695 @default.
• W2893064906 cites W2048391838 @default.
• W2893064906 cites W2050484662 @default.
• W2893064906 cites W2053327687 @default.
• W2893064906 cites W2055043387 @default.
• W2893064906 cites W2062548620 @default.
• W2893064906 cites W2064186732 @default.
• W2893064906 cites W2067263595 @default.
• W2893064906 cites W2070582535 @default.
• W2893064906 cites W2070591805 @default.
• W2893064906 cites W2071037185 @default.
• W2893064906 cites W2071655323 @default.
• W2893064906 cites W2072628432 @default.
• W2893064906 cites W2073589226 @default.
• W2893064906 cites W2074830661 @default.
• W2893064906 cites W2079162819 @default.
• W2893064906 cites W2080752012 @default.
• W2893064906 cites W2083885449 @default.
• W2893064906 cites W2085111644 @default.
• W2893064906 cites W2085597672 @default.
• W2893064906 cites W2087482176 @default.
• W2893064906 cites W2089720783 @default.
• W2893064906 cites W2091366683 @default.
• W2893064906 cites W2096173332 @default.
• W2893064906 cites W2097087000 @default.
• W2893064906 cites W2103270369 @default.
• W2893064906 cites W2103291048 @default.
• W2893064906 cites W2103868360 @default.
• W2893064906 cites W2104063702 @default.
• W2893064906 cites W2107704801 @default.
• W2893064906 cites W2109470426 @default.
• W2893064906 cites W2111647009 @default.
• W2893064906 cites W2113454307 @default.
• W2893064906 cites W2116087519 @default.
• W2893064906 cites W2118327902 @default.
• W2893064906 cites W2120790798 @default.
• W2893064906 cites W2131124686 @default.
• W2893064906 cites W2134888531 @default.
• W2893064906 cites W2135581618 @default.
• W2893064906 cites W2138140504 @default.
• W2893064906 cites W2138255346 @default.
• W2893064906 cites W2138816083 @default.
• W2893064906 cites W2142282255 @default.
• W2893064906 cites W2143326696 @default.
• W2893064906 cites W2143877047 @default.

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