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• W2893067327 abstract "Abstract Background Although it is accepted that the etiology of cerebral small vessel disease (CSVD) is associated with cardiovascular risk factors, the association between CSVD and the circadian rhythm of blood pressure (BP) is unclear. We aimed to determine if such an association existed in the elderly population. Method White matter hyperintensities (WMHs), lacunes, microbleeds, nocturnal dipping pattern (NDP), and morning surge in systolic blood pressure (SBP) were assessed in 2,091 participants ≥60 years of age. Results During an average of 63 months of follow-up, WMH and the WMH-to-intracranial volume ratio were significantly increased in extreme dippers, nondippers, and reverse dippers than those in dippers (p < .001). For new-incident Fazekas scale ≥2, the hazard ratios were 1.77 (95% confidence interval [CI], 1.09–2.86) for extreme dippers, 2.20 (95% CI, 1.48–3.28) for nondippers, and 2.43 (95% CI, 1.59–3.70) for reverse dippers compared with dippers, and 1.04 (95% CI, 0.81–1.35) for higher morning surge compared with lower morning surge. Nondippers and reverse dippers were associated with higher risks of new-incident lacunes and microbleeds than dippers (p < .05). Higher morning surge was associated with a higher risk of new-incident microbleeds than lower morning surge (p < .05). Conclusion NDPs in SBP played an important role in CSVD, and the morning surge in SBP was associated with cerebral microbleeds in community-based elderly population beyond the average SBP level." @default.
• W2893067327 created "2018-10-05" @default.
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• W2893067327 date "2018-09-25" @default.
• W2893067327 modified "2023-10-15" @default.
• W2893067327 title "Association of Circadian Rhythm of Blood Pressure and Cerebral Small Vessel Disease in Community-Based Elderly Population" @default.
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• W2893067327 doi "https://doi.org/10.1093/gerona/gly212" @default.
• W2893067327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30252020" @default.
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