Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893082238> ?p ?o ?g. }
- W2893082238 endingPage "11671" @default.
- W2893082238 startingPage "11663" @default.
- W2893082238 abstract "TAS2R14 is of great potential as a therapeutic target against asthma, and the discovery of TAS2R14 agonists can be very valuable for treating this disease. Herein, we developed a strategy using virtual screening and affinity screening based on a fabricated biosensor combined with UPLC-MS analysis to screen TAS2R14 agonists from Platycodon grandiflorum. By ligand-based virtual screening, 16 best-fit candidates were yielded. A novel TAS2R14-functionalized high-electron-mobility transistor (HEMT) sensor was applied to detect and fish out the potential TAS2R14 agonists from P. grandiflorum extracts. Those components captured by the immobilized TAS2R14 were eluted and characterized on UPLC-QTOF MS. As a result, six potential TAS2R14 agonists were screened out and identified. Among them, platycodin L was confirmed to be a special agonist of TAS2R14 for the first time and had an EC50 of 15.03 ± 1.15 μM via intracellular calcium mobilization assay ( n = 6). The results indicated that the proposed strategy was efficient to discover TAS2R14 agonists from the herb directly." @default.
- W2893082238 created "2018-10-05" @default.
- W2893082238 creator A5010951409 @default.
- W2893082238 creator A5011519309 @default.
- W2893082238 creator A5014844124 @default.
- W2893082238 creator A5018165752 @default.
- W2893082238 creator A5021555728 @default.
- W2893082238 creator A5049817947 @default.
- W2893082238 creator A5059715294 @default.
- W2893082238 creator A5066579528 @default.
- W2893082238 creator A5075204483 @default.
- W2893082238 date "2018-09-27" @default.
- W2893082238 modified "2023-09-24" @default.
- W2893082238 title "Discovery of TAS2R14 Agonists from <i>Platycodon grandiflorum</i> Using Virtual Screening and Affinity Screening Based on a Novel TAS2R14-Functionalized HEMT Sensor Combined with UPLC–MS Analysis" @default.
- W2893082238 cites W1881182904 @default.
- W2893082238 cites W1910664855 @default.
- W2893082238 cites W1965145037 @default.
- W2893082238 cites W2013257613 @default.
- W2893082238 cites W2023242124 @default.
- W2893082238 cites W2033389722 @default.
- W2893082238 cites W2034023488 @default.
- W2893082238 cites W2036927671 @default.
- W2893082238 cites W2049319231 @default.
- W2893082238 cites W2051608577 @default.
- W2893082238 cites W2053247668 @default.
- W2893082238 cites W2062583447 @default.
- W2893082238 cites W2077057718 @default.
- W2893082238 cites W2082269792 @default.
- W2893082238 cites W2087812087 @default.
- W2893082238 cites W2099045180 @default.
- W2893082238 cites W2100646932 @default.
- W2893082238 cites W2121145363 @default.
- W2893082238 cites W2122168617 @default.
- W2893082238 cites W2122283286 @default.
- W2893082238 cites W2133302347 @default.
- W2893082238 cites W2137263528 @default.
- W2893082238 cites W2137311570 @default.
- W2893082238 cites W2156596404 @default.
- W2893082238 cites W2169702025 @default.
- W2893082238 cites W2318142819 @default.
- W2893082238 cites W2493601894 @default.
- W2893082238 cites W2540476748 @default.
- W2893082238 cites W2550404534 @default.
- W2893082238 cites W2606526099 @default.
- W2893082238 doi "https://doi.org/10.1021/acs.jafc.8b04455" @default.
- W2893082238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30259737" @default.
- W2893082238 hasPublicationYear "2018" @default.
- W2893082238 type Work @default.
- W2893082238 sameAs 2893082238 @default.
- W2893082238 citedByCount "8" @default.
- W2893082238 countsByYear W28930822382020 @default.
- W2893082238 countsByYear W28930822382021 @default.
- W2893082238 countsByYear W28930822382022 @default.
- W2893082238 countsByYear W28930822382023 @default.
- W2893082238 crossrefType "journal-article" @default.
- W2893082238 hasAuthorship W2893082238A5010951409 @default.
- W2893082238 hasAuthorship W2893082238A5011519309 @default.
- W2893082238 hasAuthorship W2893082238A5014844124 @default.
- W2893082238 hasAuthorship W2893082238A5018165752 @default.
- W2893082238 hasAuthorship W2893082238A5021555728 @default.
- W2893082238 hasAuthorship W2893082238A5049817947 @default.
- W2893082238 hasAuthorship W2893082238A5059715294 @default.
- W2893082238 hasAuthorship W2893082238A5066579528 @default.
- W2893082238 hasAuthorship W2893082238A5075204483 @default.
- W2893082238 hasConcept C103697762 @default.
- W2893082238 hasConcept C170493617 @default.
- W2893082238 hasConcept C179998833 @default.
- W2893082238 hasConcept C185592680 @default.
- W2893082238 hasConcept C21951064 @default.
- W2893082238 hasConcept C2778938600 @default.
- W2893082238 hasConcept C43617362 @default.
- W2893082238 hasConcept C55493867 @default.
- W2893082238 hasConcept C74187038 @default.
- W2893082238 hasConceptScore W2893082238C103697762 @default.
- W2893082238 hasConceptScore W2893082238C170493617 @default.
- W2893082238 hasConceptScore W2893082238C179998833 @default.
- W2893082238 hasConceptScore W2893082238C185592680 @default.
- W2893082238 hasConceptScore W2893082238C21951064 @default.
- W2893082238 hasConceptScore W2893082238C2778938600 @default.
- W2893082238 hasConceptScore W2893082238C43617362 @default.
- W2893082238 hasConceptScore W2893082238C55493867 @default.
- W2893082238 hasConceptScore W2893082238C74187038 @default.
- W2893082238 hasFunder F4320321001 @default.
- W2893082238 hasFunder F4320321543 @default.
- W2893082238 hasIssue "44" @default.
- W2893082238 hasLocation W28930822381 @default.
- W2893082238 hasLocation W28930822382 @default.
- W2893082238 hasOpenAccess W2893082238 @default.
- W2893082238 hasPrimaryLocation W28930822381 @default.
- W2893082238 hasRelatedWork W2052269448 @default.
- W2893082238 hasRelatedWork W2095306786 @default.
- W2893082238 hasRelatedWork W2114353500 @default.
- W2893082238 hasRelatedWork W2145213465 @default.
- W2893082238 hasRelatedWork W2189200885 @default.
- W2893082238 hasRelatedWork W2352674505 @default.
- W2893082238 hasRelatedWork W2360903818 @default.
- W2893082238 hasRelatedWork W2405302437 @default.
- W2893082238 hasRelatedWork W2417209194 @default.