Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893086779> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2893086779 abstract "This thesis is concerned with the synthesis, characterisation, and purification of 19 organoiridium(III) complexes, seventeen of which are novel. The complexes are of the general structure [CpX Ir(azopyridine)Z]A, where the iridium centre is coordinated to either a pentamethyl-cyclopentadienyl (Cp*) ligand, a tetramethyl(phenyl)-cyclopentadienyl Cpxph ligand, or a tetramethyl(biphenyl)-cyclopentadienyl Cpxbiph ligand. The azopyridine acts as an N,N-chelated bidentate ligand with a variety of substituents, the chemical and biological e↵ects of which are investigated. Z represents a monodentate halido ligand. In this work, complexes with chlorido and iodido ligands in this position are investigated. A represents the counterion to the cationic organoiridium complex. In this work, complexes bearing the hexafluorophosphate (PF6 ), Cl , and I anions are investigated. X-ray crystal structures of eight of the complexes are determined, confirming that the complexes adopt the expected ’piano-stool’ configuration. The anticancer properties of these complexes are thoroughly investigated in multiple cancer cell lines, revealing that several are more potent than many clinically-utilised chemotherapeutics including cisplatin (CDDP), as well as many previously reported metal-based anticancer complexes. The mechanism of action (MoA) of this family of complexes has been investigated, revealing an MoA based on the generation of reactive oxygen species (ROS) and superoxide (SO) in addition to mitochondrial membrane depolarisation. Drugs with this MoA hold the potential to selectively kill cancer cells over normal ones as cancer cells have higher levels of basal ROS and are therefore more sensitive to perturbation of their ROS balance. The charge, solubility, hydrophobicity, hydrolytic behaviour, and mechanism of action (MoA) of these complexes can all be modified with small synthetically trivial adjustments, resulting in highly potent complexes. This demonstrates this family of complexes as an effective and versatile platform for drug design." @default.
- W2893086779 created "2018-10-05" @default.
- W2893086779 creator A5049500886 @default.
- W2893086779 date "2018-01-01" @default.
- W2893086779 modified "2023-09-23" @default.
- W2893086779 title "Design and mechanism of action of novel organoiridium(iii) azopyridine anticancer complexes" @default.
- W2893086779 hasPublicationYear "2018" @default.
- W2893086779 type Work @default.
- W2893086779 sameAs 2893086779 @default.
- W2893086779 citedByCount "0" @default.
- W2893086779 crossrefType "dissertation" @default.
- W2893086779 hasAuthorship W2893086779A5049500886 @default.
- W2893086779 hasConcept C115624301 @default.
- W2893086779 hasConcept C116569031 @default.
- W2893086779 hasConcept C141071460 @default.
- W2893086779 hasConcept C145148216 @default.
- W2893086779 hasConcept C154881586 @default.
- W2893086779 hasConcept C161790260 @default.
- W2893086779 hasConcept C170493617 @default.
- W2893086779 hasConcept C178516000 @default.
- W2893086779 hasConcept C178790620 @default.
- W2893086779 hasConcept C181458950 @default.
- W2893086779 hasConcept C185592680 @default.
- W2893086779 hasConcept C2776694085 @default.
- W2893086779 hasConcept C2777598222 @default.
- W2893086779 hasConcept C2778239845 @default.
- W2893086779 hasConcept C34814092 @default.
- W2893086779 hasConcept C528581852 @default.
- W2893086779 hasConcept C55493867 @default.
- W2893086779 hasConcept C71240020 @default.
- W2893086779 hasConcept C71924100 @default.
- W2893086779 hasConcept C8010536 @default.
- W2893086779 hasConceptScore W2893086779C115624301 @default.
- W2893086779 hasConceptScore W2893086779C116569031 @default.
- W2893086779 hasConceptScore W2893086779C141071460 @default.
- W2893086779 hasConceptScore W2893086779C145148216 @default.
- W2893086779 hasConceptScore W2893086779C154881586 @default.
- W2893086779 hasConceptScore W2893086779C161790260 @default.
- W2893086779 hasConceptScore W2893086779C170493617 @default.
- W2893086779 hasConceptScore W2893086779C178516000 @default.
- W2893086779 hasConceptScore W2893086779C178790620 @default.
- W2893086779 hasConceptScore W2893086779C181458950 @default.
- W2893086779 hasConceptScore W2893086779C185592680 @default.
- W2893086779 hasConceptScore W2893086779C2776694085 @default.
- W2893086779 hasConceptScore W2893086779C2777598222 @default.
- W2893086779 hasConceptScore W2893086779C2778239845 @default.
- W2893086779 hasConceptScore W2893086779C34814092 @default.
- W2893086779 hasConceptScore W2893086779C528581852 @default.
- W2893086779 hasConceptScore W2893086779C55493867 @default.
- W2893086779 hasConceptScore W2893086779C71240020 @default.
- W2893086779 hasConceptScore W2893086779C71924100 @default.
- W2893086779 hasConceptScore W2893086779C8010536 @default.
- W2893086779 hasLocation W28930867791 @default.
- W2893086779 hasOpenAccess W2893086779 @default.
- W2893086779 hasPrimaryLocation W28930867791 @default.
- W2893086779 hasRelatedWork W1503019488 @default.
- W2893086779 hasRelatedWork W1547050896 @default.
- W2893086779 hasRelatedWork W2023653247 @default.
- W2893086779 hasRelatedWork W2052617076 @default.
- W2893086779 hasRelatedWork W2063401440 @default.
- W2893086779 hasRelatedWork W2077688929 @default.
- W2893086779 hasRelatedWork W2119730164 @default.
- W2893086779 hasRelatedWork W2344459782 @default.
- W2893086779 hasRelatedWork W2803313138 @default.
- W2893086779 hasRelatedWork W2808654802 @default.
- W2893086779 hasRelatedWork W2809304393 @default.
- W2893086779 hasRelatedWork W2885656034 @default.
- W2893086779 hasRelatedWork W2889006785 @default.
- W2893086779 hasRelatedWork W2899560774 @default.
- W2893086779 hasRelatedWork W2918638117 @default.
- W2893086779 hasRelatedWork W2946826516 @default.
- W2893086779 hasRelatedWork W3109309032 @default.
- W2893086779 hasRelatedWork W3129883794 @default.
- W2893086779 hasRelatedWork W3130079353 @default.
- W2893086779 hasRelatedWork W3199694819 @default.
- W2893086779 isParatext "false" @default.
- W2893086779 isRetracted "false" @default.
- W2893086779 magId "2893086779" @default.
- W2893086779 workType "dissertation" @default.