FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893087988> ?p ?o ?g. }

• W2893087988 endingPage "404" @default.
• W2893087988 startingPage "399" @default.
• W2893087988 abstract "Pin1, a peptidyl prolyl cis/trans isomerase (PPIase), regulates the activity and stability of various phosphorylated proteins. Pin1 consists of a PPIase domain and WW domain, both of which are required for the function of Pin1. However, how the behavior of these domains changes upon binding to phosphorylated proteins has not been analyzed. We created a Fluorescent Resonance Energy Transfer (FRET)-based biosensor CPinY, which is composed of Pin1 flanked by CFP and YFP, and analyzed the interaction between Pin1 and c-Myc. Our results indicated that the dual phosphorylation of c-Myc at Thr58 and Ser62 is essential for tight interaction with Pin1. Additionally, this interaction caused a significant conformational change in Pin1. Our CPinY biosensor also detected a novel type of inhibitor of Pin1 function. We believe that his biosensor will be a novel drug screening technology targeting Pin1." @default.
• W2893087988 created "2018-10-05" @default.
• W2893087988 creator A5006893997 @default.
• W2893087988 creator A5013641311 @default.
• W2893087988 creator A5050574613 @default.
• W2893087988 creator A5076453895 @default.
• W2893087988 creator A5083189982 @default.
• W2893087988 creator A5090644657 @default.
• W2893087988 date "2018-10-01" @default.
• W2893087988 modified "2023-09-24" @default.
• W2893087988 title "Fluorescent resonance energy transfer -based biosensor for detecting conformational changes of Pin1" @default.
• W2893087988 cites W1813253026 @default.
• W2893087988 cites W1958433286 @default.
• W2893087988 cites W1977911183 @default.
• W2893087988 cites W1980726951 @default.
• W2893087988 cites W1983871031 @default.
• W2893087988 cites W1986489099 @default.
• W2893087988 cites W1989223012 @default.
• W2893087988 cites W2010637511 @default.
• W2893087988 cites W2013014822 @default.
• W2893087988 cites W2019721868 @default.
• W2893087988 cites W2034230941 @default.
• W2893087988 cites W2039210066 @default.
• W2893087988 cites W2042690324 @default.
• W2893087988 cites W2050000741 @default.
• W2893087988 cites W2063394559 @default.
• W2893087988 cites W2075530203 @default.
• W2893087988 cites W2082747164 @default.
• W2893087988 cites W2086751197 @default.
• W2893087988 cites W2091267904 @default.
• W2893087988 cites W2092108176 @default.
• W2893087988 cites W2098034303 @default.
• W2893087988 cites W2105214585 @default.
• W2893087988 cites W2113675798 @default.
• W2893087988 cites W2132527654 @default.
• W2893087988 cites W2142733497 @default.
• W2893087988 cites W2178735716 @default.
• W2893087988 cites W2189436152 @default.
• W2893087988 cites W2562506927 @default.
• W2893087988 cites W2568867352 @default.
• W2893087988 cites W2584374048 @default.
• W2893087988 cites W2760285959 @default.
• W2893087988 cites W2791285421 @default.
• W2893087988 cites W2796056335 @default.
• W2893087988 doi "https://doi.org/10.1016/j.bbrc.2018.09.123" @default.
• W2893087988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30262141" @default.
• W2893087988 hasPublicationYear "2018" @default.
• W2893087988 type Work @default.
• W2893087988 sameAs 2893087988 @default.
• W2893087988 citedByCount "2" @default.
• W2893087988 countsByYear W28930879882020 @default.
• W2893087988 countsByYear W28930879882022 @default.
• W2893087988 crossrefType "journal-article" @default.
• W2893087988 hasAuthorship W2893087988A5006893997 @default.
• W2893087988 hasAuthorship W2893087988A5013641311 @default.
• W2893087988 hasAuthorship W2893087988A5050574613 @default.
• W2893087988 hasAuthorship W2893087988A5076453895 @default.
• W2893087988 hasAuthorship W2893087988A5083189982 @default.
• W2893087988 hasAuthorship W2893087988A5090644657 @default.
• W2893087988 hasConcept C104317684 @default.
• W2893087988 hasConcept C11960822 @default.
• W2893087988 hasConcept C121332964 @default.
• W2893087988 hasConcept C12554922 @default.
• W2893087988 hasConcept C133956753 @default.
• W2893087988 hasConcept C14036430 @default.
• W2893087988 hasConcept C154472170 @default.
• W2893087988 hasConcept C160756335 @default.
• W2893087988 hasConcept C181199279 @default.
• W2893087988 hasConcept C185592680 @default.
• W2893087988 hasConcept C204491159 @default.
• W2893087988 hasConcept C2777339483 @default.
• W2893087988 hasConcept C2781098309 @default.
• W2893087988 hasConcept C2781264208 @default.
• W2893087988 hasConcept C2910677434 @default.
• W2893087988 hasConcept C55493867 @default.
• W2893087988 hasConcept C62520636 @default.
• W2893087988 hasConcept C86803240 @default.
• W2893087988 hasConcept C91881484 @default.
• W2893087988 hasConcept C95444343 @default.
• W2893087988 hasConcept C96305047 @default.
• W2893087988 hasConceptScore W2893087988C104317684 @default.
• W2893087988 hasConceptScore W2893087988C11960822 @default.
• W2893087988 hasConceptScore W2893087988C121332964 @default.
• W2893087988 hasConceptScore W2893087988C12554922 @default.
• W2893087988 hasConceptScore W2893087988C133956753 @default.
• W2893087988 hasConceptScore W2893087988C14036430 @default.
• W2893087988 hasConceptScore W2893087988C154472170 @default.
• W2893087988 hasConceptScore W2893087988C160756335 @default.
• W2893087988 hasConceptScore W2893087988C181199279 @default.
• W2893087988 hasConceptScore W2893087988C185592680 @default.
• W2893087988 hasConceptScore W2893087988C204491159 @default.
• W2893087988 hasConceptScore W2893087988C2777339483 @default.
• W2893087988 hasConceptScore W2893087988C2781098309 @default.
• W2893087988 hasConceptScore W2893087988C2781264208 @default.
• W2893087988 hasConceptScore W2893087988C2910677434 @default.
• W2893087988 hasConceptScore W2893087988C55493867 @default.
• W2893087988 hasConceptScore W2893087988C62520636 @default.
• W2893087988 hasConceptScore W2893087988C86803240 @default.

• next