FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893090074> ?p ?o ?g. }

• W2893090074 abstract "Osteoporosis (OP) is an age-related disease, and osteoporotic fracture is one of the major causes of disability and mortality in elderly patients (>70 years old). As the pathogenesis and molecular mechanism of OP remain unclear, the identification of disease biomarkers is important for guiding research and providing therapeutic targets. In the present study, core genes and microRNAs (miRNAs) associated with OP were identified. Differentially expressed genes (DEGs) between human mesenchymal stem cell specimens from normal osseous tissues and OP tissues were detected using the GEO2R tool of the Gene Expression Omnibus database and Morpheus. Network topological parameters were determined using NetworkAnalyzer. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using the Database for Annotation, Visualization and Integrated Discovery, and ClueGO. Cytoscape with the Search Tool for the Retrieval of Interacting Genes and Molecular Complex Detection plug-in was used to visualize protein-protein interactions (PPIs). Additionally, miRNA-gene regulatory modules were predicted using CyTargetLinker in order to guide future research. In total, 915 DEGs were identified, including 774 upregulated and 141 downregulated genes. Enriched GO terms and pathways were determined, including 'nervous system development', 'regulation of molecular function', 'glutamatergic synapse pathway' and 'pathways in cancer'. The node degrees of DEGs followed power-law distributions. A PPI network with 541 nodes and 1,431 edges was obtained. Overall, 3 important modules were identified from the PPI network. The following 10 genes were identified as core genes based on high degrees of connectivity: Albumin, PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2), DNA topoisomerase 2-α, kininogen 1 (KNG1), interleukin 2 (IL2), leucine-rich repeats and guanylate kinase domain containing, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ (PIK3CG), leptin, transferrin and RNA polymerase II subunit A (POLR2A). Additionally, 15 miRNA-target interactions were obtained using CyTargetLinker. Overall, 7 miRNAs co-regulated IL2, 3 regulated PHLPP2, 3 regulated KNG1, 1 regulated PIK3CG and 1 modulated POLR2A. These results indicate potential biomarkers in the pathogenesis of OP and therapeutic targets." @default.
• W2893090074 created "2018-10-05" @default.
• W2893090074 creator A5018453094 @default.
• W2893090074 creator A5025969340 @default.
• W2893090074 creator A5047232406 @default.
• W2893090074 creator A5069354250 @default.
• W2893090074 creator A5070348501 @default.
• W2893090074 date "2018-09-26" @default.
• W2893090074 modified "2023-09-26" @default.
• W2893090074 title "Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach" @default.
• W2893090074 cites W1973097912 @default.
• W2893090074 cites W1976384386 @default.
• W2893090074 cites W1978961990 @default.
• W2893090074 cites W1982878502 @default.
• W2893090074 cites W2002227779 @default.
• W2893090074 cites W2005178884 @default.
• W2893090074 cites W2009288080 @default.
• W2893090074 cites W2020161366 @default.
• W2893090074 cites W2023957036 @default.
• W2893090074 cites W2028279436 @default.
• W2893090074 cites W2031982181 @default.
• W2893090074 cites W2038856775 @default.
• W2893090074 cites W2043310411 @default.
• W2893090074 cites W2043570667 @default.
• W2893090074 cites W2047071057 @default.
• W2893090074 cites W2061710919 @default.
• W2893090074 cites W2069668624 @default.
• W2893090074 cites W2071642941 @default.
• W2893090074 cites W2087697015 @default.
• W2893090074 cites W2096173332 @default.
• W2893090074 cites W2100376124 @default.
• W2893090074 cites W2103017472 @default.
• W2893090074 cites W2108357988 @default.
• W2893090074 cites W2110838720 @default.
• W2893090074 cites W2118258530 @default.
• W2893090074 cites W2130443006 @default.
• W2893090074 cites W2136850043 @default.
• W2893090074 cites W2153705400 @default.
• W2893090074 cites W2156737316 @default.
• W2893090074 cites W2158217645 @default.
• W2893090074 cites W2159482845 @default.
• W2893090074 cites W2159675211 @default.
• W2893090074 cites W2160315579 @default.
• W2893090074 cites W2166683880 @default.
• W2893090074 cites W2167898988 @default.
• W2893090074 cites W2169589032 @default.
• W2893090074 cites W2213814370 @default.
• W2893090074 cites W2224687466 @default.
• W2893090074 cites W2227012744 @default.
• W2893090074 cites W2326767535 @default.
• W2893090074 cites W2417040142 @default.
• W2893090074 cites W2512683982 @default.
• W2893090074 cites W2529169464 @default.
• W2893090074 cites W2549111903 @default.
• W2893090074 cites W2562035630 @default.
• W2893090074 cites W2563570743 @default.
• W2893090074 cites W2591633725 @default.
• W2893090074 cites W2607729957 @default.
• W2893090074 cites W2746178589 @default.
• W2893090074 cites W2765817783 @default.
• W2893090074 cites W2781505287 @default.
• W2893090074 cites W2810166862 @default.
• W2893090074 cites W2884633578 @default.
• W2893090074 doi "https://doi.org/10.3892/ol.2018.9508" @default.
• W2893090074 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6313156" @default.
• W2893090074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30655789" @default.
• W2893090074 hasPublicationYear "2018" @default.
• W2893090074 type Work @default.
• W2893090074 sameAs 2893090074 @default.
• W2893090074 citedByCount "2" @default.
• W2893090074 countsByYear W28930900742019 @default.
• W2893090074 countsByYear W28930900742022 @default.
• W2893090074 crossrefType "journal-article" @default.
• W2893090074 hasAuthorship W2893090074A5018453094 @default.
• W2893090074 hasAuthorship W2893090074A5025969340 @default.
• W2893090074 hasAuthorship W2893090074A5047232406 @default.
• W2893090074 hasAuthorship W2893090074A5069354250 @default.
• W2893090074 hasAuthorship W2893090074A5070348501 @default.
• W2893090074 hasBestOaLocation W28930900741 @default.
• W2893090074 hasConcept C104317684 @default.
• W2893090074 hasConcept C145059251 @default.
• W2893090074 hasConcept C150194340 @default.
• W2893090074 hasConcept C152724338 @default.
• W2893090074 hasConcept C162317418 @default.
• W2893090074 hasConcept C54355233 @default.
• W2893090074 hasConcept C55105296 @default.
• W2893090074 hasConcept C60644358 @default.
• W2893090074 hasConcept C67339327 @default.
• W2893090074 hasConcept C70721500 @default.
• W2893090074 hasConcept C86803240 @default.
• W2893090074 hasConceptScore W2893090074C104317684 @default.
• W2893090074 hasConceptScore W2893090074C145059251 @default.
• W2893090074 hasConceptScore W2893090074C150194340 @default.
• W2893090074 hasConceptScore W2893090074C152724338 @default.
• W2893090074 hasConceptScore W2893090074C162317418 @default.
• W2893090074 hasConceptScore W2893090074C54355233 @default.
• W2893090074 hasConceptScore W2893090074C55105296 @default.
• W2893090074 hasConceptScore W2893090074C60644358 @default.
• W2893090074 hasConceptScore W2893090074C67339327 @default.
• W2893090074 hasConceptScore W2893090074C70721500 @default.

• next