FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893096870> ?p ?o ?g. }

• W2893096870 endingPage "10809" @default.
• W2893096870 startingPage "10804" @default.
• W2893096870 abstract "Somatic copy number variations (CNVs) exist in the brain, but their genesis, prevalence, forms, and biological impact remain unclear, even within experimentally tractable animal models. We combined a transposase-based amplification (TbA) methodology for single-cell whole-genome sequencing with a bioinformatic approach for filtering unreliable CNVs (FUnC), developed from machine learning trained on lymphocyte V(D)J recombination. TbA-FUnC offered superior genomic coverage and removed >90% of false-positive CNV calls, allowing extensive examination of submegabase CNVs from over 500 cells throughout the neurogenic period of cerebral cortical development in Mus musculus Thousands of previously undocumented CNVs were identified. Half were less than 1 Mb in size, with deletions 4× more common than amplification events, and were randomly distributed throughout the genome. However, CNV prevalence during embryonic cortical development was nonrandom, peaking at midneurogenesis with levels triple those found at younger ages before falling to intermediate quantities. These data identify pervasive small and large CNVs as early contributors to neural genomic mosaicism, producing genomically diverse cellular building blocks that form the highly organized, mature brain." @default.
• W2893096870 created "2018-10-05" @default.
• W2893096870 creator A5009825394 @default.
• W2893096870 creator A5014799222 @default.
• W2893096870 creator A5020349193 @default.
• W2893096870 creator A5038524862 @default.
• W2893096870 creator A5044840158 @default.
• W2893096870 creator A5064303801 @default.
• W2893096870 creator A5088966167 @default.
• W2893096870 date "2018-09-27" @default.
• W2893096870 modified "2023-09-23" @default.
• W2893096870 title "Submegabase copy number variations arise during cerebral cortical neurogenesis as revealed by single-cell whole-genome sequencing" @default.
• W2893096870 cites W1601755300 @default.
• W2893096870 cites W1975466959 @default.
• W2893096870 cites W1981749204 @default.
• W2893096870 cites W2007326275 @default.
• W2893096870 cites W2011816180 @default.
• W2893096870 cites W2018486235 @default.
• W2893096870 cites W2034979835 @default.
• W2893096870 cites W2036495352 @default.
• W2893096870 cites W2053955820 @default.
• W2893096870 cites W2061794007 @default.
• W2893096870 cites W2066803056 @default.
• W2893096870 cites W2067233122 @default.
• W2893096870 cites W2068674866 @default.
• W2893096870 cites W2073931069 @default.
• W2893096870 cites W2082019169 @default.
• W2893096870 cites W2088470456 @default.
• W2893096870 cites W2096320678 @default.
• W2893096870 cites W2097455931 @default.
• W2893096870 cites W2098041458 @default.
• W2893096870 cites W2105970624 @default.
• W2893096870 cites W2111747321 @default.
• W2893096870 cites W2123490990 @default.
• W2893096870 cites W2127714237 @default.
• W2893096870 cites W2133174470 @default.
• W2893096870 cites W2154508650 @default.
• W2893096870 cites W2158255377 @default.
• W2893096870 cites W2236083456 @default.
• W2893096870 cites W2288957736 @default.
• W2893096870 cites W2411962548 @default.
• W2893096870 cites W2580989000 @default.
• W2893096870 cites W2811382536 @default.
• W2893096870 cites W2884645464 @default.
• W2893096870 doi "https://doi.org/10.1073/pnas.1812702115" @default.
• W2893096870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6196524" @default.
• W2893096870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30262650" @default.
• W2893096870 hasPublicationYear "2018" @default.
• W2893096870 type Work @default.
• W2893096870 sameAs 2893096870 @default.
• W2893096870 citedByCount "40" @default.
• W2893096870 countsByYear W28930968702018 @default.
• W2893096870 countsByYear W28930968702019 @default.
• W2893096870 countsByYear W28930968702020 @default.
• W2893096870 countsByYear W28930968702021 @default.
• W2893096870 countsByYear W28930968702022 @default.
• W2893096870 countsByYear W28930968702023 @default.
• W2893096870 crossrefType "journal-article" @default.
• W2893096870 hasAuthorship W2893096870A5009825394 @default.
• W2893096870 hasAuthorship W2893096870A5014799222 @default.
• W2893096870 hasAuthorship W2893096870A5020349193 @default.
• W2893096870 hasAuthorship W2893096870A5038524862 @default.
• W2893096870 hasAuthorship W2893096870A5044840158 @default.
• W2893096870 hasAuthorship W2893096870A5064303801 @default.
• W2893096870 hasAuthorship W2893096870A5088966167 @default.
• W2893096870 hasBestOaLocation W28930968701 @default.
• W2893096870 hasConcept C104317684 @default.
• W2893096870 hasConcept C120821319 @default.
• W2893096870 hasConcept C134305767 @default.
• W2893096870 hasConcept C141231307 @default.
• W2893096870 hasConcept C24432333 @default.
• W2893096870 hasConcept C4746552 @default.
• W2893096870 hasConcept C54355233 @default.
• W2893096870 hasConcept C70721500 @default.
• W2893096870 hasConcept C86803240 @default.
• W2893096870 hasConceptScore W2893096870C104317684 @default.
• W2893096870 hasConceptScore W2893096870C120821319 @default.
• W2893096870 hasConceptScore W2893096870C134305767 @default.
• W2893096870 hasConceptScore W2893096870C141231307 @default.
• W2893096870 hasConceptScore W2893096870C24432333 @default.
• W2893096870 hasConceptScore W2893096870C4746552 @default.
• W2893096870 hasConceptScore W2893096870C54355233 @default.
• W2893096870 hasConceptScore W2893096870C70721500 @default.
• W2893096870 hasConceptScore W2893096870C86803240 @default.
• W2893096870 hasFunder F4320337330 @default.
• W2893096870 hasFunder F4320337354 @default.
• W2893096870 hasIssue "42" @default.
• W2893096870 hasLocation W28930968701 @default.
• W2893096870 hasLocation W28930968702 @default.
• W2893096870 hasLocation W28930968703 @default.
• W2893096870 hasLocation W28930968704 @default.
• W2893096870 hasOpenAccess W2893096870 @default.
• W2893096870 hasPrimaryLocation W28930968701 @default.
• W2893096870 hasRelatedWork W1965921640 @default.
• W2893096870 hasRelatedWork W1979853113 @default.
• W2893096870 hasRelatedWork W2027675659 @default.
• W2893096870 hasRelatedWork W2058336589 @default.
• W2893096870 hasRelatedWork W2085953447 @default.

• next