FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893102839> ?p ?o ?g. }

• W2893102839 endingPage "129" @default.
• W2893102839 startingPage "129" @default.
• W2893102839 abstract "Hydrogen sulfide (H2S) has arisen as a critical gasotransmitter signaling molecule modulating cellular biological events related to health and diseases in heart, brain, liver, vascular systems and immune response. Three enzymes mediate the endogenous production of H2S: cystathione β-synthase (CBS), cystathione γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST). CBS and CSE localizations are organ-specific. 3-MST is a mitochondrial and cytosolic enzyme. The generation of H2S is firmly regulated by these enzymes under normal physiological conditions. Recent studies have highlighted the role of H2S in cellular redox homeostasis, as it displays significant antioxidant properties. H2S exerts antioxidant effects through several mechanisms, such as quenching reactive oxygen species (ROS) and reactive nitrogen species (RNS), by modulating cellular levels of glutathione (GSH) and thioredoxin (Trx-1) or increasing expression of antioxidant enzymes (AOE), by activating the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2). H2S also influences the activity of the histone deacetylase protein family of sirtuins, which plays an important role in inhibiting oxidative stress in cardiomyocytes and during the aging process by modulating AOE gene expression. This review focuses on the role of H2S in NRF2 and sirtuin signaling pathways as they are related to cellular redox homeostasis." @default.
• W2893102839 created "2018-10-05" @default.
• W2893102839 creator A5063837536 @default.
• W2893102839 creator A5069867734 @default.
• W2893102839 creator A5086442862 @default.
• W2893102839 date "2018-09-28" @default.
• W2893102839 modified "2023-10-06" @default.
• W2893102839 title "Role of Hydrogen Sulfide in NRF2- and Sirtuin-Dependent Maintenance of Cellular Redox Balance" @default.
• W2893102839 cites W1487516961 @default.
• W2893102839 cites W1551392207 @default.
• W2893102839 cites W1839879290 @default.
• W2893102839 cites W1965247936 @default.
• W2893102839 cites W1966849251 @default.
• W2893102839 cites W1975509532 @default.
• W2893102839 cites W1976306764 @default.
• W2893102839 cites W1976539175 @default.
• W2893102839 cites W1978772332 @default.
• W2893102839 cites W1980773214 @default.
• W2893102839 cites W1993293015 @default.
• W2893102839 cites W1998774601 @default.
• W2893102839 cites W2006242918 @default.
• W2893102839 cites W2006340346 @default.
• W2893102839 cites W2011591403 @default.
• W2893102839 cites W2020444237 @default.
• W2893102839 cites W2020770681 @default.
• W2893102839 cites W2024355544 @default.
• W2893102839 cites W2026066526 @default.
• W2893102839 cites W2038350505 @default.
• W2893102839 cites W2041415712 @default.
• W2893102839 cites W2074730055 @default.
• W2893102839 cites W2096000363 @default.
• W2893102839 cites W2103645537 @default.
• W2893102839 cites W2107312159 @default.
• W2893102839 cites W2110899027 @default.
• W2893102839 cites W2116268698 @default.
• W2893102839 cites W2116488609 @default.
• W2893102839 cites W2132013398 @default.
• W2893102839 cites W2153957651 @default.
• W2893102839 cites W2160081886 @default.
• W2893102839 cites W2162645036 @default.
• W2893102839 cites W2164206394 @default.
• W2893102839 cites W2164663685 @default.
• W2893102839 cites W2165803250 @default.
• W2893102839 cites W2194611754 @default.
• W2893102839 cites W2269031989 @default.
• W2893102839 cites W2512747501 @default.
• W2893102839 cites W2513682992 @default.
• W2893102839 cites W2547106927 @default.
• W2893102839 cites W2550456386 @default.
• W2893102839 cites W2588161361 @default.
• W2893102839 cites W2606353696 @default.
• W2893102839 cites W2607595152 @default.
• W2893102839 cites W2609696365 @default.
• W2893102839 cites W2613446160 @default.
• W2893102839 cites W2616187808 @default.
• W2893102839 cites W2753402350 @default.
• W2893102839 cites W2766780446 @default.
• W2893102839 cites W2774598579 @default.
• W2893102839 cites W2784043971 @default.
• W2893102839 cites W2791288341 @default.
• W2893102839 cites W2793344252 @default.
• W2893102839 cites W2810415057 @default.
• W2893102839 cites W584911205 @default.
• W2893102839 doi "https://doi.org/10.3390/antiox7100129" @default.
• W2893102839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6210431" @default.
• W2893102839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30274149" @default.
• W2893102839 hasPublicationYear "2018" @default.
• W2893102839 type Work @default.
• W2893102839 sameAs 2893102839 @default.
• W2893102839 citedByCount "97" @default.
• W2893102839 countsByYear W28931028392019 @default.
• W2893102839 countsByYear W28931028392020 @default.
• W2893102839 countsByYear W28931028392021 @default.
• W2893102839 countsByYear W28931028392022 @default.
• W2893102839 countsByYear W28931028392023 @default.
• W2893102839 crossrefType "journal-article" @default.
• W2893102839 hasAuthorship W2893102839A5063837536 @default.
• W2893102839 hasAuthorship W2893102839A5069867734 @default.
• W2893102839 hasAuthorship W2893102839A5086442862 @default.
• W2893102839 hasBestOaLocation W28931028391 @default.
• W2893102839 hasConcept C104317684 @default.
• W2893102839 hasConcept C150555746 @default.
• W2893102839 hasConcept C181199279 @default.
• W2893102839 hasConcept C185592680 @default.
• W2893102839 hasConcept C2776151105 @default.
• W2893102839 hasConcept C2776529522 @default.
• W2893102839 hasConcept C2778004101 @default.
• W2893102839 hasConcept C2778305200 @default.
• W2893102839 hasConcept C2779201268 @default.
• W2893102839 hasConcept C2779525624 @default.
• W2893102839 hasConcept C2780561631 @default.
• W2893102839 hasConcept C2780637352 @default.
• W2893102839 hasConcept C3623737 @default.
• W2893102839 hasConcept C48349386 @default.
• W2893102839 hasConcept C538909803 @default.
• W2893102839 hasConcept C55493867 @default.
• W2893102839 hasConcept C62478195 @default.
• W2893102839 hasConcept C64927066 @default.

• next