FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893120722> ?p ?o ?g. }

• W2893120722 endingPage "294" @default.
• W2893120722 startingPage "286" @default.
• W2893120722 abstract "Maternal immune activation (MIA) with the viral mimic poly I:C provides an established rodent model for studying schizophrenia (SZ) and other human neurodevelopmental disorders. Postnatal infections are additional risk factors in SZ and may cumulatively contribute to the emergence of pathophysiology. Underlying mechanisms may involve metabolites of the kynurenine pathway (KP) of tryptophan degradation, which is readily induced by inflammatory stimuli. Here we compared the expression of selected cytokines and KP enzymes, and the levels of selected KP metabolites, in the brain of MIA offspring following a second, acute immune challenge with lipopolysaccharides (LPS) on postnatal day (PND) 35 (adolescence) or PND 60 (early adulthood). Assessed in adolescence, MIA did not alter the expression of pro-inflammatory cytokines (except TNF-α) or KP metabolite levels compared to controls, but substantially reduced the expression of the anti-inflammatory cytokines IL-4 and IL-10 and influenced the expression of two of the four KP enzymes examined (IDO1 and TDO2). LPS treatment caused distinct changes in the expression of pro- and anti-inflammatory cytokines, as well as KP enzymes in MIA offspring, but had no effect on KP metabolites compared to control rats. Several of these effects were blunted in MIA offspring receiving LPS on PND 60. Notably, LPS caused a significant reduction in brain kynurenine levels in these animals. Of relevance for SZ-related hypotheses, these results indicate that MIA leads to an increasingly defective, rather than an overactive, immune regulation of cerebral KP metabolism during the postnatal period." @default.
• W2893120722 created "2018-10-05" @default.
• W2893120722 creator A5020040467 @default.
• W2893120722 creator A5022526821 @default.
• W2893120722 creator A5030849116 @default.
• W2893120722 creator A5049171963 @default.
• W2893120722 creator A5050632840 @default.
• W2893120722 creator A5065349385 @default.
• W2893120722 date "2019-03-01" @default.
• W2893120722 modified "2023-10-18" @default.
• W2893120722 title "Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood" @default.
• W2893120722 cites W1548862642 @default.
• W2893120722 cites W1850313342 @default.
• W2893120722 cites W1965661602 @default.
• W2893120722 cites W1985613691 @default.
• W2893120722 cites W1989657907 @default.
• W2893120722 cites W1989839225 @default.
• W2893120722 cites W1994455271 @default.
• W2893120722 cites W1996580716 @default.
• W2893120722 cites W1998639400 @default.
• W2893120722 cites W2002231678 @default.
• W2893120722 cites W2006730702 @default.
• W2893120722 cites W2007305673 @default.
• W2893120722 cites W2013524799 @default.
• W2893120722 cites W2017661386 @default.
• W2893120722 cites W2023145239 @default.
• W2893120722 cites W2024215324 @default.
• W2893120722 cites W2028370746 @default.
• W2893120722 cites W2031337229 @default.
• W2893120722 cites W2041812587 @default.
• W2893120722 cites W2042914870 @default.
• W2893120722 cites W2049985274 @default.
• W2893120722 cites W2050792638 @default.
• W2893120722 cites W2056370816 @default.
• W2893120722 cites W2060928023 @default.
• W2893120722 cites W2063026836 @default.
• W2893120722 cites W2065971435 @default.
• W2893120722 cites W2066704028 @default.
• W2893120722 cites W2079199493 @default.
• W2893120722 cites W2081326601 @default.
• W2893120722 cites W2083667275 @default.
• W2893120722 cites W2085301448 @default.
• W2893120722 cites W2085571457 @default.
• W2893120722 cites W2086208662 @default.
• W2893120722 cites W2087539536 @default.
• W2893120722 cites W2092196742 @default.
• W2893120722 cites W2095681536 @default.
• W2893120722 cites W2098597355 @default.
• W2893120722 cites W2104000439 @default.
• W2893120722 cites W2110729320 @default.
• W2893120722 cites W2110837219 @default.
• W2893120722 cites W2114570899 @default.
• W2893120722 cites W2118643787 @default.
• W2893120722 cites W2121637331 @default.
• W2893120722 cites W2122840791 @default.
• W2893120722 cites W2124859215 @default.
• W2893120722 cites W2126795224 @default.
• W2893120722 cites W2134209166 @default.
• W2893120722 cites W2135627297 @default.
• W2893120722 cites W2137823415 @default.
• W2893120722 cites W2139194458 @default.
• W2893120722 cites W2141645427 @default.
• W2893120722 cites W2142972284 @default.
• W2893120722 cites W2143217444 @default.
• W2893120722 cites W2149671708 @default.
• W2893120722 cites W2154965665 @default.
• W2893120722 cites W2170455434 @default.
• W2893120722 cites W2330498227 @default.
• W2893120722 cites W2338925098 @default.
• W2893120722 cites W2372817497 @default.
• W2893120722 cites W2397045879 @default.
• W2893120722 cites W2407689217 @default.
• W2893120722 cites W2429429632 @default.
• W2893120722 cites W2474061866 @default.
• W2893120722 cites W2508076655 @default.
• W2893120722 cites W2515897135 @default.
• W2893120722 cites W2574742999 @default.
• W2893120722 cites W2591810884 @default.
• W2893120722 cites W2607931113 @default.
• W2893120722 cites W2738214434 @default.
• W2893120722 cites W2765389138 @default.
• W2893120722 cites W92736930 @default.
• W2893120722 doi "https://doi.org/10.1016/j.pnpbp.2018.09.011" @default.
• W2893120722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6249106" @default.
• W2893120722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30267854" @default.
• W2893120722 hasPublicationYear "2019" @default.
• W2893120722 type Work @default.
• W2893120722 sameAs 2893120722 @default.
• W2893120722 citedByCount "38" @default.
• W2893120722 countsByYear W28931207222019 @default.
• W2893120722 countsByYear W28931207222020 @default.
• W2893120722 countsByYear W28931207222021 @default.
• W2893120722 countsByYear W28931207222022 @default.
• W2893120722 countsByYear W28931207222023 @default.
• W2893120722 crossrefType "journal-article" @default.
• W2893120722 hasAuthorship W2893120722A5020040467 @default.
• W2893120722 hasAuthorship W2893120722A5022526821 @default.
• W2893120722 hasAuthorship W2893120722A5030849116 @default.

• next