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- W2893146790 endingPage "e0204325" @default.
- W2893146790 startingPage "e0204325" @default.
- W2893146790 abstract "Amine oxidase, which participates in the metabolic processing of biogenic amines, is widely found in organisms, including higher organisms and various microorganisms. In this study, the full-length cDNA of a novel amine oxidase gene was cloned from the mud crab, Scylla paramamosain, and termed SpAMO. The cDNA sequence was 2,599 bp in length, including an open reading frame of 1,521 bp encoding 506 amino acids. Two amino acid sequence motifs, a flavin adenine dinucleotide-binding domain and a flavin-containing amine oxidoreductase, were highly conserved in SpAMO. A quantitative real-time polymerase chain reaction analysis showed that the expression level of SpAMO after quercetin treatment was time- and concentration-dependent. The expression of SpAMO tended to decrease and then increase in the brain and haemolymph after treatment with 5 mg/kg/d quercetin; after treatment with 50 mg/kg/d quercetin, the expression of SpAMO declined rapidly and remained low in the brain and haemolymph. These results indicated that quercetin could inhibit the transcription of SpAMO, and the high dose (50 mg/kg/d) had a relatively significant inhibitory effect. SpAMO showed the highest catalytic activity on serotonin, followed by dopamine, β-phenylethylamine, and spermine, suggesting that the specific substrates of SpAMO are serotonin and dopamine. A bioinformatics analysis of SpAMO showed that it has molecular characteristics of spermine oxidase, but a quercetin test and enzyme activity study indicated that it also functions like monoamine oxidase. It is speculated that SpAMO might be a novel amine oxidase in S. paramamosain that has the functions of both spermine oxidase and monoamine oxidase." @default.
- W2893146790 created "2018-10-05" @default.
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- W2893146790 date "2018-09-24" @default.
- W2893146790 modified "2023-09-25" @default.
- W2893146790 title "An amine oxidase gene from mud crab, Scylla paramamosain, regulates the neurotransmitters serotonin and dopamine in vitro" @default.
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- W2893146790 doi "https://doi.org/10.1371/journal.pone.0204325" @default.
- W2893146790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6152983" @default.
- W2893146790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30248122" @default.
- W2893146790 hasPublicationYear "2018" @default.
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