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• W2893149238 abstract "Adenosine is an endogenous neuroprotectant that modulates vasodilation in the central nervous system. Oxygen changes occur when there is an increase in local cerebral blood flow and thus are a measure of vasodilation. Transient oxygen events following rapid adenosine events have been recently discovered, but the relationship between adenosine and blood flow change during ischemia/reperfusion (I/R) has not been characterized. Caffeine is a nonselective adenosine receptor antagonist that can modulate the effects of adenosine in the brain, but how it affects adenosine and oxygen levels during I/R is also unknown. In this study, extracellular changes in adenosine and oxygen were simultaneously monitored using fast-scan cyclic voltammetry during bilateral common carotid artery occlusion (BCCAO) and the effects of a specific A2A antagonist, SCH 442416, or general antagonist, caffeine, were studied. Measurements were made in the caudate-putamen for 1 h of normoxia, followed by 30 min of BCCAO and 30 min of reperfusion. The frequency and number of both adenosine and oxygen transient events significantly increased during I/R. The specific A2A antagonist, SCH 442416 (3 mg/kg, i.p.), eliminated the increase in adenosine and oxygen events caused by I/R. The general adenosine receptor antagonist, caffeine (100 mg/kg, i.p.), decreased the frequency of adenosine and oxygen transient events during I/R. These results demonstrate that, during BCCAO, there are more rapid release events of the neuromodulator adenosine and correlated local oxygen changes, and these rapid, local effects are dampened by caffeine and other A2A antagonists." @default.
• W2893149238 created "2018-10-05" @default.
• W2893149238 creator A5062858517 @default.
• W2893149238 creator A5081790927 @default.
• W2893149238 date "2018-09-25" @default.
• W2893149238 modified "2023-10-10" @default.
• W2893149238 title "Caffeine Modulates Spontaneous Adenosine and Oxygen Changes during Ischemia and Reperfusion" @default.
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• W2893149238 doi "https://doi.org/10.1021/acschemneuro.8b00251" @default.
• W2893149238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7003050" @default.
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• W2893149238 hasPublicationYear "2018" @default.
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