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- W2893149691 abstract "Abstract Oogenesis involves a complex differentiation program leading to the production of functional oocytes. Oogonia originating from primordial germ cells proliferate by mitosis and form primary oocytes that arrest at the prophase of the first meiotic division. Meiosis resumes only in a fully grown meiotically competent oocyte before ovulation and completes upon fertilization. Oocyte developmental competence is gained in a gradual and sequential manner. It depends on a vast number of intra- and extraovarian factors, being accompanied by dramatic changes in the nucleus and unique transcriptional activity of the oocyte. The fertilized oocyte endows the embryo with intracellular determinants and genetic material, which are required for initiating and sustaining early embryogenesis. Both the nuclear and the mitochondrial genome drive the oocyte through the stages of differentiation and morphogenesis, and are important for normal embryo development. The key differentiation events occurring during oogenesis encompass the crucial developmental checkpoints, allowing uninterrupted progression of the oocyte through the stages of development and maturation. The errors may result in reproductive failure, adverse pregnancy outcomes, or genetic disorders in offspring. This chapter provides a summary of the recent exponentially increasing knowledge in the molecular biology of the oocyte, emphasizing the key factors involved in oogenesis and the genetic determinants of oocyte maturation." @default.
- W2893149691 created "2018-10-05" @default.
- W2893149691 creator A5003517853 @default.
- W2893149691 creator A5043840909 @default.
- W2893149691 creator A5060729531 @default.
- W2893149691 creator A5068794190 @default.
- W2893149691 date "2019-01-01" @default.
- W2893149691 modified "2023-09-25" @default.
- W2893149691 title "The Molecular Genetics of Oogenesis" @default.
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