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• W2893152832 endingPage "3550" @default.
• W2893152832 startingPage "3540" @default.
• W2893152832 abstract "Abstract Visuospatial working memory (WM), which is impaired in schizophrenia, depends on a distributed network including visual, posterior parietal, and dorsolateral prefrontal cortical regions. Within each region, information processing is differentially regulated by subsets of γ-aminobutyric acid (GABA) neurons that express parvalbumin (PV), somatostatin (SST), or vasoactive intestinal peptide (VIP). In schizophrenia, WM impairments have been associated with alterations of PV and SST neurons in the dorsolateral prefrontal cortex. Here, we quantified transcripts selectively expressed in GABA neuron subsets across four cortical regions in the WM network from comparison and schizophrenia subjects. In comparison subjects, PV mRNA levels declined and SST mRNA levels increased from posterior to anterior regions, whereas VIP mRNA levels were comparable across regions except for the primary visual cortex (V1). In schizophrenia subjects, each transcript in PV and SST neurons exhibited similar alterations across all regions, whereas transcripts in VIP neurons were unaltered in any region except for V1. These findings suggest that the contribution of each GABA neuron subset to inhibitory regulation of local circuitry normally differs across cortical regions of the visuospatial WM network and that in schizophrenia alterations of PV and SST neurons are a shared feature across these regions, whereas VIP neurons are affected only in V1." @default.
• W2893152832 created "2018-10-05" @default.
• W2893152832 creator A5024651931 @default.
• W2893152832 creator A5047091057 @default.
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• W2893152832 creator A5060048341 @default.
• W2893152832 creator A5067303077 @default.
• W2893152832 creator A5072516978 @default.
• W2893152832 creator A5076241114 @default.
• W2893152832 date "2018-09-24" @default.
• W2893152832 modified "2023-10-17" @default.
• W2893152832 title "Expression of Transcripts Selective for GABA Neuron Subpopulations across the Cortical Visuospatial Working Memory Network in the Healthy State and Schizophrenia" @default.
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• W2893152832 doi "https://doi.org/10.1093/cercor/bhy227" @default.
• W2893152832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6644854" @default.
• W2893152832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30247542" @default.
• W2893152832 hasPublicationYear "2018" @default.
• W2893152832 type Work @default.
• W2893152832 sameAs 2893152832 @default.

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