Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893168086> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2893168086 endingPage "1544" @default.
- W2893168086 startingPage "1533" @default.
- W2893168086 abstract "Polycations are generally used to work as delivery vector to develop siRNA-based therapy for gene-related diseases. The contradiction between inevitable toxicity, internalization, and pharmacokinetics of polycations/siRNA is a critical challenge for polycations and impedes their further application. Herein, we synthesized the ECMD polycations and constructed ECMD/siRNA/HA complexes with slight negative charge to address the above mentioned issue. We found that equipping with HA could effectively shield the positive charge and dramatically improve cell viability. Moreover, the ternary complexes with slight negative charge exhibited similar cellular uptake efficiency and knockdown efficiency compared with ECMD/siRNA binary complexes because of CD44 protein-mediated endocytosis. Pharmacokinetics experiment and in vivo distribution elucidated that the ternary complexes with negative charge could help to prolong the circulation time of siRNA in blood and affect the organs distribution after i.v. injection. In addition, with time going by, the accumulation amount of siRNA loaded by the ternary complexes was much more in tumor compared with the binary complexes. Therefore, we believed that building the complexes was a feasible method to further develop polycationic vectors for siRNA delivery." @default.
- W2893168086 created "2018-10-05" @default.
- W2893168086 creator A5004092063 @default.
- W2893168086 creator A5009199887 @default.
- W2893168086 creator A5026825966 @default.
- W2893168086 creator A5028769173 @default.
- W2893168086 creator A5031070620 @default.
- W2893168086 creator A5044124706 @default.
- W2893168086 creator A5047544719 @default.
- W2893168086 creator A5053825134 @default.
- W2893168086 creator A5067431012 @default.
- W2893168086 creator A5081756957 @default.
- W2893168086 creator A5087586345 @default.
- W2893168086 date "2017-11-01" @default.
- W2893168086 modified "2023-09-27" @default.
- W2893168086 title "Balancing Biocompatibility, Internalization and Pharmacokinetics of Polycations/siRNA by Structuring the Weak Negative Charged Ternary Complexes with Hyaluronic Acid" @default.
- W2893168086 doi "https://doi.org/10.1166/jbn.2017.2438" @default.
- W2893168086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31271139" @default.
- W2893168086 hasPublicationYear "2017" @default.
- W2893168086 type Work @default.
- W2893168086 sameAs 2893168086 @default.
- W2893168086 citedByCount "3" @default.
- W2893168086 countsByYear W28931680862019 @default.
- W2893168086 countsByYear W28931680862020 @default.
- W2893168086 countsByYear W28931680862021 @default.
- W2893168086 crossrefType "journal-article" @default.
- W2893168086 hasAuthorship W2893168086A5004092063 @default.
- W2893168086 hasAuthorship W2893168086A5009199887 @default.
- W2893168086 hasAuthorship W2893168086A5026825966 @default.
- W2893168086 hasAuthorship W2893168086A5028769173 @default.
- W2893168086 hasAuthorship W2893168086A5031070620 @default.
- W2893168086 hasAuthorship W2893168086A5044124706 @default.
- W2893168086 hasAuthorship W2893168086A5047544719 @default.
- W2893168086 hasAuthorship W2893168086A5053825134 @default.
- W2893168086 hasAuthorship W2893168086A5067431012 @default.
- W2893168086 hasAuthorship W2893168086A5081756957 @default.
- W2893168086 hasAuthorship W2893168086A5087586345 @default.
- W2893168086 hasConcept C104317684 @default.
- W2893168086 hasConcept C112705442 @default.
- W2893168086 hasConcept C12554922 @default.
- W2893168086 hasConcept C139770010 @default.
- W2893168086 hasConcept C1491633281 @default.
- W2893168086 hasConcept C173396325 @default.
- W2893168086 hasConcept C178790620 @default.
- W2893168086 hasConcept C18150654 @default.
- W2893168086 hasConcept C185154212 @default.
- W2893168086 hasConcept C185592680 @default.
- W2893168086 hasConcept C199360897 @default.
- W2893168086 hasConcept C2777529286 @default.
- W2893168086 hasConcept C2779820397 @default.
- W2893168086 hasConcept C28005876 @default.
- W2893168086 hasConcept C41008148 @default.
- W2893168086 hasConcept C54355233 @default.
- W2893168086 hasConcept C55493867 @default.
- W2893168086 hasConcept C64452783 @default.
- W2893168086 hasConcept C86803240 @default.
- W2893168086 hasConcept C98274493 @default.
- W2893168086 hasConceptScore W2893168086C104317684 @default.
- W2893168086 hasConceptScore W2893168086C112705442 @default.
- W2893168086 hasConceptScore W2893168086C12554922 @default.
- W2893168086 hasConceptScore W2893168086C139770010 @default.
- W2893168086 hasConceptScore W2893168086C1491633281 @default.
- W2893168086 hasConceptScore W2893168086C173396325 @default.
- W2893168086 hasConceptScore W2893168086C178790620 @default.
- W2893168086 hasConceptScore W2893168086C18150654 @default.
- W2893168086 hasConceptScore W2893168086C185154212 @default.
- W2893168086 hasConceptScore W2893168086C185592680 @default.
- W2893168086 hasConceptScore W2893168086C199360897 @default.
- W2893168086 hasConceptScore W2893168086C2777529286 @default.
- W2893168086 hasConceptScore W2893168086C2779820397 @default.
- W2893168086 hasConceptScore W2893168086C28005876 @default.
- W2893168086 hasConceptScore W2893168086C41008148 @default.
- W2893168086 hasConceptScore W2893168086C54355233 @default.
- W2893168086 hasConceptScore W2893168086C55493867 @default.
- W2893168086 hasConceptScore W2893168086C64452783 @default.
- W2893168086 hasConceptScore W2893168086C86803240 @default.
- W2893168086 hasConceptScore W2893168086C98274493 @default.
- W2893168086 hasIssue "11" @default.
- W2893168086 hasLocation W28931680861 @default.
- W2893168086 hasLocation W28931680862 @default.
- W2893168086 hasOpenAccess W2893168086 @default.
- W2893168086 hasPrimaryLocation W28931680861 @default.
- W2893168086 hasRelatedWork W1849031117 @default.
- W2893168086 hasRelatedWork W1974661973 @default.
- W2893168086 hasRelatedWork W1982459820 @default.
- W2893168086 hasRelatedWork W1987002621 @default.
- W2893168086 hasRelatedWork W2059488077 @default.
- W2893168086 hasRelatedWork W2070705082 @default.
- W2893168086 hasRelatedWork W2108339776 @default.
- W2893168086 hasRelatedWork W2332911520 @default.
- W2893168086 hasRelatedWork W2955542935 @default.
- W2893168086 hasRelatedWork W4206180686 @default.
- W2893168086 hasVolume "13" @default.
- W2893168086 isParatext "false" @default.
- W2893168086 isRetracted "false" @default.
- W2893168086 magId "2893168086" @default.
- W2893168086 workType "article" @default.