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• W2893168905 endingPage "4641" @default.
• W2893168905 startingPage "4629" @default.
• W2893168905 abstract "Two types of vertebrate cryptochromes (Crys) are currently recognized. Type 2 Crys function in the molecular circadian clock as light-independent transcriptional repressors. Type 4 Crys are a newly discovered group with unknown function, although they are flavoproteins, and therefore, may function as photoreceptors. It has been postulated that Crys function in light-dependent magnetoreception, which is thought to contribute towards homing and migratory behaviors. Here we have cloned and annotated the full-length pigeon ClCry1, ClCry2, and ClCry4 genes, and characterized the full-length proteins and several site-directed mutants to investigate the roles of these proteins. ClCry1 and ClCry2 are phylogenetically grouped as Type 2 Crys and thus are expected to be core components of the pigeon circadian clock. Interestingly, we find that ClCry4 is properly annotated as a Type 4 Cry. It appears that many birds possess a Type 4 Cry which, as in pigeon, is misannotated. Like the Type 2 Crys, ClCry4 is widespread in pigeon tissues. However, unlike the Type 2 Crys, ClCry4 is cytosolic, and purified ClCry4 possesses FAD cofactor, which confers characteristic UV-Vis spectra as well as two photochemical activities. We find that ClCry4 undergoes light-dependent conformational change, which is a property of insect Type 1 Crys involved in the insect-specific pathway of photoentrainment of the biological clock. ClCry4 can also be photochemically reduced by a mechanism common to all FAD-containing Cry family members, and this mechanism is postulated to be influenced by the geomagnetic field. Thus pigeon Crys control circadian behavior and may also have photosensory function." @default.
• W2893168905 created "2018-10-05" @default.
• W2893168905 creator A5016678671 @default.
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• W2893168905 date "2018-09-27" @default.
• W2893168905 modified "2023-10-17" @default.
• W2893168905 title "Comparative properties and functions of type 2 and type 4 pigeon cryptochromes" @default.
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• W2893168905 doi "https://doi.org/10.1007/s00018-018-2920-y" @default.
• W2893168905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6383368" @default.
• W2893168905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30264181" @default.
• W2893168905 hasPublicationYear "2018" @default.
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