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• W2893172333 abstract "Oridonin is an active component of the traditional Chinese herb Rabdosia rubescens. The present study aimed to evaluate the antitumor effects of oridonin on human non-small cell lung cancer (NSCLC) cells and explore whether oridonin could enhance their radiosensitivity. Oridonin was demonstrated to inhibit the proliferation of SPC-A-1 and HCC827 lung cancer cells in a time- and dose-dependent manner, which was detected using the MTT assay. In addition, pretreatment with oridonin for 24 h prior to irradiation was identified to enhance the radiosensitivity of SPC-A-1 cells. Furthermore, the levels of apoptosis regulator BAX (Bax) and apoptosis regulator Bcl-2 (Bcl-2) were detected by western blotting analysis. The results demonstrated that the level of Bax was increased and the level of Bcl-2 was decreased in SPC-A-1 cells treated with oridonin and irradiation compared with the group that received irradiation alone. These results indicate that oridonin may have a novel application as a radiosensitizing agent for the treatment of human NSCLC." @default.
• W2893172333 created "2018-10-05" @default.
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• W2893172333 date "2018-09-27" @default.
• W2893172333 modified "2023-10-16" @default.
• W2893172333 title "Oridonin enhances the radiosensitivity of lung cancer cells by upregulating Bax and downregulating Bcl‑2" @default.
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• W2893172333 doi "https://doi.org/10.3892/etm.2018.6803" @default.
• W2893172333 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6256844" @default.
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