Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893179621> ?p ?o ?g. }
- W2893179621 endingPage "174" @default.
- W2893179621 startingPage "169" @default.
- W2893179621 abstract "Gait and balance impairment is common in secondary progressive multiple sclerosis (SPMS). Lipoic acid (LA), an over-the-counter antioxidant, is effective in MS animal models and may improve walking speed, but effects on mobility are unreported. Examine the effects of 1200 mg daily oral dose of LA versus placebo (PLA) on gait and balance in a 2-year, randomized, double-blind pilot study. 134 participants were screened for eligibility before assignment to LA (n = 28) or PLA (n = 26). Included here were, 21 participants with SPMS who took LA (N = 11) or PLA (N = 10) capsules for 2 years (enrolled May 2, 2011 – August 14, 2015) and completed all tasks without the use of an assistive device. Participants completed the Timed Up and Go (TUG) and quiet standing tasks every 6 months while wearing inertial sensors (APDM Opals) to quantify mobility. LA had a medium effect on time to complete TUG at 2 years (g = 0.51; 95% CI = -0.35, 1.38). In a subset of 18 participants with less disability (EDSS < 6, no use of ambulatory device), turning time was significantly shorter with LA (p = 0.048, Δ= 0.48 s). No differences in balance metrics were found between groups. LA had an effect on walking performance in people with SPMS, particularly in those with lower baseline disability. Lipoic Acid for Secondary Progressive Multiple Sclerosis https://clinicaltrials.gov/ct2/show/NCT01188811?term=spain+lipoic+acid&rank=1 NCT0118881." @default.
- W2893179621 created "2018-10-05" @default.
- W2893179621 creator A5017645785 @default.
- W2893179621 creator A5047802487 @default.
- W2893179621 creator A5057706417 @default.
- W2893179621 creator A5068632109 @default.
- W2893179621 creator A5075683314 @default.
- W2893179621 date "2018-12-01" @default.
- W2893179621 modified "2023-10-08" @default.
- W2893179621 title "Effects of lipoic acid on walking performance, gait, and balance in secondary progressive multiple sclerosis" @default.
- W2893179621 cites W1598301969 @default.
- W2893179621 cites W1891102068 @default.
- W2893179621 cites W2000900321 @default.
- W2893179621 cites W2001818617 @default.
- W2893179621 cites W2004488368 @default.
- W2893179621 cites W2017420045 @default.
- W2893179621 cites W2019983337 @default.
- W2893179621 cites W2021268227 @default.
- W2893179621 cites W2028417880 @default.
- W2893179621 cites W2033993719 @default.
- W2893179621 cites W2037557484 @default.
- W2893179621 cites W2039043944 @default.
- W2893179621 cites W2049787664 @default.
- W2893179621 cites W2060371114 @default.
- W2893179621 cites W2068967233 @default.
- W2893179621 cites W2108487302 @default.
- W2893179621 cites W2110822990 @default.
- W2893179621 cites W2113588185 @default.
- W2893179621 cites W2117276061 @default.
- W2893179621 cites W2127251573 @default.
- W2893179621 cites W2137710256 @default.
- W2893179621 cites W2145481931 @default.
- W2893179621 cites W2156691412 @default.
- W2893179621 cites W2163738265 @default.
- W2893179621 cites W2267564478 @default.
- W2893179621 cites W2280304830 @default.
- W2893179621 cites W2326826867 @default.
- W2893179621 cites W2725212050 @default.
- W2893179621 cites W2806902795 @default.
- W2893179621 cites W2916040650 @default.
- W2893179621 cites W4243177274 @default.
- W2893179621 doi "https://doi.org/10.1016/j.ctim.2018.09.006" @default.
- W2893179621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6263172" @default.
- W2893179621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30477834" @default.
- W2893179621 hasPublicationYear "2018" @default.
- W2893179621 type Work @default.
- W2893179621 sameAs 2893179621 @default.
- W2893179621 citedByCount "19" @default.
- W2893179621 countsByYear W28931796212019 @default.
- W2893179621 countsByYear W28931796212020 @default.
- W2893179621 countsByYear W28931796212021 @default.
- W2893179621 countsByYear W28931796212022 @default.
- W2893179621 countsByYear W28931796212023 @default.
- W2893179621 crossrefType "journal-article" @default.
- W2893179621 hasAuthorship W2893179621A5017645785 @default.
- W2893179621 hasAuthorship W2893179621A5047802487 @default.
- W2893179621 hasAuthorship W2893179621A5057706417 @default.
- W2893179621 hasAuthorship W2893179621A5068632109 @default.
- W2893179621 hasAuthorship W2893179621A5075683314 @default.
- W2893179621 hasBestOaLocation W28931796211 @default.
- W2893179621 hasConcept C118552586 @default.
- W2893179621 hasConcept C126322002 @default.
- W2893179621 hasConcept C142724271 @default.
- W2893179621 hasConcept C151800584 @default.
- W2893179621 hasConcept C168031717 @default.
- W2893179621 hasConcept C168563851 @default.
- W2893179621 hasConcept C185592680 @default.
- W2893179621 hasConcept C1862650 @default.
- W2893179621 hasConcept C204787440 @default.
- W2893179621 hasConcept C27081682 @default.
- W2893179621 hasConcept C2778004101 @default.
- W2893179621 hasConcept C2779491571 @default.
- W2893179621 hasConcept C2780640218 @default.
- W2893179621 hasConcept C35785553 @default.
- W2893179621 hasConcept C55493867 @default.
- W2893179621 hasConcept C70770792 @default.
- W2893179621 hasConcept C71924100 @default.
- W2893179621 hasConcept C99508421 @default.
- W2893179621 hasConceptScore W2893179621C118552586 @default.
- W2893179621 hasConceptScore W2893179621C126322002 @default.
- W2893179621 hasConceptScore W2893179621C142724271 @default.
- W2893179621 hasConceptScore W2893179621C151800584 @default.
- W2893179621 hasConceptScore W2893179621C168031717 @default.
- W2893179621 hasConceptScore W2893179621C168563851 @default.
- W2893179621 hasConceptScore W2893179621C185592680 @default.
- W2893179621 hasConceptScore W2893179621C1862650 @default.
- W2893179621 hasConceptScore W2893179621C204787440 @default.
- W2893179621 hasConceptScore W2893179621C27081682 @default.
- W2893179621 hasConceptScore W2893179621C2778004101 @default.
- W2893179621 hasConceptScore W2893179621C2779491571 @default.
- W2893179621 hasConceptScore W2893179621C2780640218 @default.
- W2893179621 hasConceptScore W2893179621C35785553 @default.
- W2893179621 hasConceptScore W2893179621C55493867 @default.
- W2893179621 hasConceptScore W2893179621C70770792 @default.
- W2893179621 hasConceptScore W2893179621C71924100 @default.
- W2893179621 hasConceptScore W2893179621C99508421 @default.
- W2893179621 hasLocation W28931796211 @default.
- W2893179621 hasLocation W28931796212 @default.